Abstract
Monoclonal antibody therapy in sepsis has focussed on intervention at very early stages in the pathogenesis, aiming to neutralise the potent effects of molecules such as endotoxin and tumour necrosis factor (TNF). While antibodies directed to these molecules show efficacy in the treatment of shock, it would be of considerable advantage to identify targets for intervention at later stages in the pathology. One such target is phospholipase A2 (PLA2), since this enzyme is proinflammatory (Vadas and Pruzanski 1986), and the activity in serum is associated with the onset and severity of septic shock in humans (Vadas 1984; Vadas et al. 1988).
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References
Green JA, Smith GM, Buchta R, Lee R, Ho KY, Rajkovic IA, Scott KF (1991) The circulating phospholipase A2 activity associated with sepsis is indistinguishable from that associated with rheumatoid arthritis. Inflammation 15:355–367
Lai C, Wada K (1988) Phospholipase A2 from synovial fluid: purification and structural homology to the placental enzyme. Biochem Biophys Res Commun 157:488–493
Seilhamer JJ, Pruzanski W, Vadas P, Plant S, Miller J, Kloss J, Johnsan L (1989) Cloning and recombinant expression of phospholipase A2 present in rheumatoid arthritic synovial fluid. J Biol Chem 264:5335–5338
Smith GM, Ward RL, McGuigan L, Rajkovic IA, Scott KF (1992) Measurement of human phospholipase A2 in arthritis plasma using a newly developed sandwich ELISA. Br J Rheumatol 31:175–178
Vadas P (1984) Plasma phospholipase A2 levels correlate with the hemodynamic and pulmonary changes in gram-negative septic shock in man. J Lab Clin Med 104:873–881
Vadas P, Hay JB (1983) Involvement of circulating phospholipase A2 in the pathogenesis of the hemodynamic changes in endotoxin shock. Can J Physiol Pharmacol 61:561–566
Vadas P, Pruzanski W (1986) Role of secretory phospholipase A2 in the pathobiology of disease. Lab Invest 55:391–404
Vadas P, Pruzanski W, Stefanski E (1988) Pathogenesis of hypotension in septic shock: correlation of circulatory phospholipase A2 levels with circulatory collapse, Crit Care Med 16:1–7
Verkeij HM, Westerman J, Sternby B, de Haas G (1983) The complete primary structure of phospholipase A2 from human pancreas. Biochim Biophys Acta 747:93–99
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© 1993 Springer-Verlag, Berlin Heidelberg
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Scott, K.F. et al. (1993). Phospholipase A2: A New Target for Monoclonal Antibody Therapy in Sepsis. In: Faist, E., Meakins, J.L., Schildberg, F.W. (eds) Host Defense Dysfunction in Trauma, Shock and Sepsis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77405-8_160
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DOI: https://doi.org/10.1007/978-3-642-77405-8_160
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