The Influence of Liver Regeneration on Skin Wound Healing and Lymphocyte Growth Features

  • N. Žarković
  • I. Stipančić
  • M. Hrženjak
  • Z. Ilić
  • S. Kiš
  • I. Vučković
  • M. Jurin


Although intensively studied, the mechanisms controlling tissue regeneration are still not completely understood. However, substantial data show that severe trauma, particularly burns, can impair the normal function of the immune system [14, 18]. It seems that wounding can cause both local and systemic disturbances in homeostasis, which could be further manifested even as shock or multiple organ failure. Furthermore, various pathological disorders influence protein synthesis in the liver, thus causing acute-phase response [7, 26]. However, the importance of acute-phase reactants in the regulation of homeostasis, such as tissue regeneration, immune system function, and perhaps even tumor growth control, is still uncertain. However, it seems that local growth regulating factors, as well as similar humoral factors play the most important role, at least during liver regeneration [6, 20, 28]. It is also known that the immune system itself is involved in the regulation of wound healing [2, 23].


Liver Regeneration Partially Hepatectom Skin Wound Splenic Lymphocyte Immune System Function 
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Copyright information

© Springer-Verlag, Berlin Heidelberg 1993

Authors and Affiliations

  • N. Žarković
    • 1
  • I. Stipančić
    • 2
  • M. Hrženjak
    • 1
  • Z. Ilić
    • 1
  • S. Kiš
    • 2
  • I. Vučković
    • 2
  • M. Jurin
    • 1
  1. 1.Ruder Bošković InstituteZagrebCroatia
  2. 2.Military HospitalZagrebCroatia

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