The Influence of Liver Regeneration on Skin Wound Healing and Lymphocyte Growth Features

  • N. Žarković
  • I. Stipančić
  • M. Hrženjak
  • Z. Ilić
  • S. Kiš
  • I. Vučković
  • M. Jurin

Abstract

Although intensively studied, the mechanisms controlling tissue regeneration are still not completely understood. However, substantial data show that severe trauma, particularly burns, can impair the normal function of the immune system [14, 18]. It seems that wounding can cause both local and systemic disturbances in homeostasis, which could be further manifested even as shock or multiple organ failure. Furthermore, various pathological disorders influence protein synthesis in the liver, thus causing acute-phase response [7, 26]. However, the importance of acute-phase reactants in the regulation of homeostasis, such as tissue regeneration, immune system function, and perhaps even tumor growth control, is still uncertain. However, it seems that local growth regulating factors, as well as similar humoral factors play the most important role, at least during liver regeneration [6, 20, 28]. It is also known that the immune system itself is involved in the regulation of wound healing [2, 23].

Keywords

Corticosteroid Syringe Polypeptide Alanine Bilirubin 

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References

  1. 1.
    Alexepopulos CG, Blatsiosis B, Avgerinos A (1987) Serum lipids and lipoprotein disorders in cancer patients. Cancer 60:3065–3070CrossRefGoogle Scholar
  2. 2.
    Barbul A, Breslin RJ, Woodyard JP, Wasserkrug HL, Efron G (1989) The effect of in vivo T helper and T suppressor lymphocyte depletion on wound healing. Ann Surg 209:479–483PubMedCrossRefGoogle Scholar
  3. 3.
    Barnes D (1988) Growth factors involved in repair processes: an over-view Methods Enzyme 163:707–715CrossRefGoogle Scholar
  4. 4.
    Bryckaert MC, Lindroth M, Lonnm A, Tobelem G, Wastasen A (1988) Transforming growth factor beta decreases the proliferation of human bone marrow fibroblasts by inhibiting the platelet derived growth factor binding. Exp Cell Res 179:311–321PubMedCrossRefGoogle Scholar
  5. 5.
    Bucher NLR, Swaffield MN (1975) Regulation of hepatic renegeration in rats by synergistic action of insulin and glucagon. Proc Natl Acad Sci USA 72:1157–1160PubMedCrossRefGoogle Scholar
  6. 6.
    Carr BI, Hayashi I, Branum EL, Moses HL (1986) Inhibition of DNA synthesis in rat hepatocytes by platelet-derived type beta transforming growth factor. Cancer Res 46:2330–2334PubMedGoogle Scholar
  7. 7.
    Carr WP (1983) Acute-phase proteins. Clin Rheum Dis 9:227–239PubMedGoogle Scholar
  8. 8.
    Carrico TJ, Mehrhof AI, Cohen IK (1984) Biology of wound healing. Surg Clin North Am 64:721–733PubMedGoogle Scholar
  9. 9.
    Currie RW, White FP (1981) Trauma-induced protein in rat tissues: a physiological role of “heat shock” proteins. Science 214:72–73PubMedCrossRefGoogle Scholar
  10. 10.
    Czaja AJ, Rizzo TA, Smith WR, et al. (1975) Acute liver disease after thermal injury. J Trauma, 15:887–894PubMedCrossRefGoogle Scholar
  11. 11.
    Darlington GJ, Wilson DR, Lechman LB (1986) Monocyte-conditioned medium, interleukin-1, and tumor necrosis factor stimulate the acute phase response in human hepatoma cells in vitro. J Cell Biol 103:787–793PubMedCrossRefGoogle Scholar
  12. 12.
    Deitch EA (1985) Spontaneous lymphocyte activity: an important but neglected component of the imunologic profile of the thermally injured patient. Surgery 98:587–592PubMedGoogle Scholar
  13. 13.
    Dickson PW, Bannister D, Schreiber G (1987) Minor burns lead to major changes in synthesis rates of plasma proteins in the liver. J Trauma 27:283–286PubMedCrossRefGoogle Scholar
  14. 14.
    Dobke MK, Deitch EA, Harnar TJ, Baxter CR (1989) Oxidative activity of polymorphonuclear leukocytes after thermal injury. Arch Surg 124:856–859PubMedCrossRefGoogle Scholar
  15. 15.
    Everett RM, Harrison SD Jr (1983) Clinical biochemistry. In: Foster HL, Small JD, Fox JG (eds) The mouse in biomedical research III. Academic, New York, pp 313–326Google Scholar
  16. 16.
    Gadd MA, Hansbrough JF, Hoyt DB, Ozkan N (1989) Defective T-cell surface antigen expression after mitogen stimulation. Ann Surg 209:112–118PubMedCrossRefGoogle Scholar
  17. 17.
    German Society for Clinical Chemistry (1977) Standardization of enzyme activities in biological fluids: standard method for determination of creatine kinase activity, revised draft of 1976. J clin Chem Clin Biochem 15:255–260Google Scholar
  18. 18.
    Hansbrough JF, Peterson V, Kortz E, Piacentine J (1983) Postburn immunosuppression in an animal model: monocyte dysfunction induced by burned tissue. Surgery 93:415–423PubMedGoogle Scholar
  19. 19.
    Hansbrough JF, Gadd MA (1989) Temporal analysis of murine lymphocyte subpopulation by monoclonal antibodies and dual-color flow cytometry after burn and nonburn injury Surgery 106:69–80PubMedGoogle Scholar
  20. 20.
    Hayashi I, Carr BI (1985) DNA synthesis in rat hepatocytes: inhibition by a platelet factor and stimulation by an endogenous factor. J Cell Physiol 125:82–90PubMedCrossRefGoogle Scholar
  21. 21.
    Higgins GM, Anderson RM (1931) Experimental pathology of the liver I: restoration of liver of white rat following partial surgical removal. Arch Pathol 12:185–202Google Scholar
  22. 22.
    Irvin TT (1978) Effects of malnutrition and hyperalimentation on wound healing Surg Gynecol Obstet 146:33–37PubMedGoogle Scholar
  23. 23.
    Kagan RJ, Bratescu A, Jonasson O, Matsuda T, Teodorescu M (1989) The relationship between the percentage of circulating B cells, corticosteroid levels and the other immunologic parameters in thermally injured patients. J Trauma 29:208–213PubMedCrossRefGoogle Scholar
  24. 24.
    Karmen A (1955) Transaminase activity in human blood. Appendix: note on spectrophotometric assay of glutamic oxalacetic transaminase in human blood serum. J Clin Invest 34:126–133PubMedCrossRefGoogle Scholar
  25. 25.
    Kaufmann SHE (1990) Heat shock proteins and the immune response. Immunol Today 11:129–136PubMedCrossRefGoogle Scholar
  26. 26.
    Kushner I (1988) The actue phase response: an overview. Methods Enzymol 163:373–383PubMedCrossRefGoogle Scholar
  27. 27.
    Lazarou SA, Barbul A, Wasserkrug HL, Efron G (1989) The wound is a possible source of posttraumatic immunosuppression. Arch Surg 124:1429–1431PubMedCrossRefGoogle Scholar
  28. 28.
    Leong GF, Grisham JW, Hole BV, Albright ML (1964) Effect of partial hepatectomy on DNA synthesis and mitosis in heterotopic partial autografts of rat liver. Cancer Res 24:1496–1501PubMedGoogle Scholar
  29. 29.
    Li AKC, Koroly MJ, Schattenkerk ME, Malt RD, Young M (1980) Nerve growth factor: acceleration of the rate of wound healing in mice. Proc Natl Acad Sci USA 77:4379–4381PubMedCrossRefGoogle Scholar
  30. 30.
    Nakamura T, Teramoto H, Tomity Y, Ichichara A (1986) Two types of growth inhibitor in rat platelets for primary cultured hepatocytes. Biochem Biophys Res Commun 134:755–763PubMedCrossRefGoogle Scholar
  31. 31.
    Nakayasu T, Nacy M, Okano Y, McCarty B, Harmony YAK (1986) Plasma lipoproteins can suppress accessory cell function and consequently suppress lymphocyte activation. Exp Cell Res 163:103–116PubMedCrossRefGoogle Scholar
  32. 32.
    Ninnemann JL (1982) Immunologic defences against infection: alterations following thermal injuries. J Burn Care Rehab 3:355–398CrossRefGoogle Scholar
  33. 33.
    Richter M, Jodouin CA, Moher D, Barron P (1990) Immunologic defects following trauma: a delay in immunoglobulin sythesis by cultured B cells following traumatic accidents but not elective surgery. J Trauma 30:590–596PubMedCrossRefGoogle Scholar
  34. 34.
    Ross R, Odland G (1968) Human wound repair II: inflammatory cells, epithelial-mesenchymal interrelations and fibrogenesis. J Cell Biol 39:152–168PubMedCrossRefGoogle Scholar
  35. 35.
    Sehgal PB, Grieninger G, Tosato G (Eds) (1989) Regulation of the acute phase and immune responses: interleukin-6. Ann NY Acad Sci 557:1–579Google Scholar
  36. 36.
    Sporn MB, Roberts AB, Shull JH, Smith JM, Jerrold MW, Sodek J (1983) Polypeptide transforming growth factors isolated from bovine source and used for wound healing in vivo. Science 219:1329–1330PubMedCrossRefGoogle Scholar
  37. 37.
    Steinberg D (1984) Lipoproteins and atherosclerosis: a problem in cell biology. In: Scheschter AN, Dean A, Goldberger RF (eds) The impact of protein chemistry on the biomedical sciences. Academic, Orlando, pp 251–307Google Scholar
  38. 38.
    Wroblewski F, LaDue JS (1956) Serum glutamic-pyruvic transaminase in cardiac and hepatic disease. Proc Soc Exp Biol Med 91:569–571PubMedGoogle Scholar
  39. 39.
    Žarković N, Jurin M, Danilović Ž (1987) Effects of regenerating tissue on tumor growth in vivo. Cell Diff 20 [Suppl]:112SGoogle Scholar
  40. 40.
    Žarković N, Žarković K, Jurin M, Ilić Z, Zgradić I, Danilović Ž, Gežo A (1990) Inhibition of melanoma B16 growth induced by liver regeneration. Lijec Vjesn 112:80–85PubMedGoogle Scholar
  41. 41.
    Žarković N, Salzer B, Pifat G (1992) The influence of liver regeneration and tumor growth on serum lipoprotein composition in mice. Period Biol 94:(in press)Google Scholar
  42. 42.
    Žarković N, Salzer B, Hrženjak M, Ilić Z, Pifat G, Stipančić I, Vučković I, Jurin M (1991) The effect of gallium arsenide laser irradiation and partial hepatectomy on murine skin wound healing and lipoprotein composition. Period Biol 93:359–361Google Scholar

Copyright information

© Springer-Verlag, Berlin Heidelberg 1993

Authors and Affiliations

  • N. Žarković
    • 1
  • I. Stipančić
    • 2
  • M. Hrženjak
    • 1
  • Z. Ilić
    • 1
  • S. Kiš
    • 2
  • I. Vučković
    • 2
  • M. Jurin
    • 1
  1. 1.Ruder Bošković InstituteZagrebCroatia
  2. 2.Military HospitalZagrebCroatia

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