Abstract
AMP-FLP (i.e., amplified fragment length polymorphism) technology can offer a high degree of discrimination among individuals when evaluating the potential origin of biological materials (Boerwinkle et al 1989, Budowle et al 1991, Horn et al 1989, Kasai et al 1990, Ludwig et al 1989). The technique combines the sensitivity of detection and specificity afforded by the polymerase chain reaction with the information content of variable number of tandem repeats (VNTR) loci to provide an efficacious approach to identity testing. A favorable attribute of the AMP-FLP approach to identity testing is that loci currently under study possess alleles that can be resolved readily by gel electrophoresis into discrete fragment bands (Budowle et al 1991, Allen et al 1989). Such resolution is not possible with restriction fragment length polymorphism (RFLP) analysis currently used for the examination of DNA recovered from biological materials.
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References
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© 1992 Springer-Verlag Berlin Heidelberg
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Budowle, B., Baechtel, F.S., Comey, C.T. (1992). Some Considerations for Use of AMP-FLPs for Identity Testing. In: Rittner, C., Schneider, P.M. (eds) Advances in Forensic Haemogenetics. Advances in Forensic Haemogenetics, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77324-2_2
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DOI: https://doi.org/10.1007/978-3-642-77324-2_2
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-55194-2
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