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Heterogeneity in Malignant Soft Tissue Tumors

  • H. Kosmehl
Part of the Current Topics in Pathology book series (CT PATHOLOGY, volume 89)

Abstract

Heterogeneity exists in all tumors and should thus be acknowledged as a fundamental and inherent characteristic of soft tissue tumors as well. As all pathologists know from their diagnostic work, particularly malignant soft tissue tumors may show marked heterogeneity at the morphological and/or functional level (Fidler 1978; Heppner 1984; Katenkamp 1988; Rubin 1990). The term heterogeneity as applied here can be defined as a diversity of cellular and structural features and functional determinants. This is not identical with the term “heterogeneity” used by biologists who define it with clonality only, i.e., in a heterogeneous tumor there must occur at least two different cell clones. In contrast, we use a more comprehensive definition and include all phenomena of both interclonal differences and intraclonal variabilites (compare Heppner 1984; Heppner and Miller 1989).

Keywords

Soft Tissue Sarcoma Synovial Sarcoma Soft Tissue Tumor Malignant Peripheral Nerve Sheath Tumor Malignant Fibrous Histiocytoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Abenoza P, Sibley RK (1987) Granular cell myoma and schwannoma: fine structural and immunohistochemical study. Ultrastruct Pathol 11: 19–28PubMedGoogle Scholar
  2. Albelda SM, Buck CA (1990) Integrins and other cell adhesion molecules. FASEB J 4: 2868–2888PubMedGoogle Scholar
  3. Alguacil-Garcia A (1991) Giant cell fibroblastoma recurring as dermatofibrosarcoma pro-tuberans. Amer J Surg Pathol 15: 798–801Google Scholar
  4. Alguacil-Garcia A, Unni KK, Goellner JR (1978) Malignant fibrous histiocytoma — an ultrastructural study of six cases. Amer J Clin Pathol 69: 121–129Google Scholar
  5. Altmannsberger M, Osborn M (1987) Mesenchymal tumor markers: intermediate filaments. In: Seifert G (ed) Morphological tumor markers. Current Topics in Pathology 77, Springer, Berlin Heidelberg New York, pp 155–178Google Scholar
  6. Balaton AJ, Vaury P, Videgrain M (1987) Paravertebral malignant rhabdoid tumor in an adult — a case report with immunocytochemical study. Pathol Res Pract 182: 713–716PubMedGoogle Scholar
  7. Banerjee SS, Harris M, Eyden BP, Hamid NA (1990) Granular cell variant of dermatofibrosarcoma protuberans. Histopathology 17: 375–378PubMedGoogle Scholar
  8. Beckwith JB, Palmer NF (1978) Histopathology and prognosis of Wilms’ tumor — results from the first National Wilms’ tumor study. Cancer 41: 1937–1948PubMedGoogle Scholar
  9. Beham A, Wirnsberger G, Schmid C (1986) Immunhistochemische Untersuchungen zur Differentialdiagnose des malignen fibrosen Histiozytoms. Wien Klin Wschr 98: 617–622PubMedGoogle Scholar
  10. Belza MG, Urich H (1986) Chordoma and malignant fibrous histiocytoma: evidence for transformation. Cancer 58: 1082–1087PubMedGoogle Scholar
  11. Ben-Zeev A (1985) Cell-cell interactions and cell configuration related control of vimentin and cytokeratin expression in epithelial cells and fibroblasts. Ann NY Acad Sci 455: 597–613Google Scholar
  12. Bertoni F, Picci P, Bacchini P, Capanna R, Innao V, Bacci G, Campanacci M (1983) Mesen-chymal chondrosarcoma of bone and soft tissue. Cancer 52: 533–541PubMedGoogle Scholar
  13. Bhagavan BS, Dorfman HD (1982) The signifigance of bone and cartilage formation in malignant fibrous histiocytoma of soft tissue. Cancer 49: 480–488PubMedGoogle Scholar
  14. Biggs PJ, Caren PD, Powers JM, Garvin A J (1987) Malignant rhabdoid tumor of the central nervous system. Human Pathol 18: 332–337Google Scholar
  15. Bissell M, Hall HG, Parry G (1982) How does extracellular matrix direct gene expression? J Theor Biol 99: 31–68PubMedGoogle Scholar
  16. Bittesini L, Tos APD, Fletcher CDM (1992) Metastatic malignant melanoma showing a rhabdoid phenotype — further evidence of a non-specific histological pattern. Histopathology 20: 167–170PubMedGoogle Scholar
  17. Blom PG, Stenwig AE, Sobel HS, Johannessen JV (1983) Metastasizing malignant melanoma mimicking a malignant fibrous histiocytoma. Ultrastruct Pathol 5: 307–313PubMedGoogle Scholar
  18. Boylan JF, Jackson J, Steiner MR, Shih TY, Duigou GJ, Roszman T, Fisher PB, Zimmer SG (1990) Role of the HA-ras (RasH) oncogene in mediating progression of the tumor cell phenotype (review). Anticancer Res 10: 717–724PubMedGoogle Scholar
  19. Bridge JA, Sanger WG, Neft JR, Hess MM (1990) Cytogenetic findings in a primary malignant fibrous histiocytoma of bone and the lung metastasis. Pathology 22: 16–19PubMedGoogle Scholar
  20. Bridge J A, Sreekantaiah C, Neft JR, Sandberg A A (1991) Cytogenetic findings in clear cell sarcoma of tendons and aponeuroses; malignant melanoma of soft parts. Cancer Genet Cytogenet 52: 101–106PubMedGoogle Scholar
  21. Brooks J J (1986) The significance of double phenotypic patterns and markers in human sarcomas: a new model of mesenchymal differentiation. Am J Pathol 125: 113–123PubMedGoogle Scholar
  22. Brooks JJ (1988) Malignant schwannomas with divergent differentiation including the “Triton” tumor. In: Williams CJ, Krikorian JG, Greene MR, Raghavan D (eds) Textbook of uncommon cancer. John Wiley, New York, pp 653–668Google Scholar
  23. Brooks JJ, Freeman M, Enterline HT (1985) Malignant “Triton” tumors: natural history and immunohistochemistry of nine new cases with literature review. Cancer 55: 2543–2549PubMedGoogle Scholar
  24. Brown DC, Theaker JM, Banks PM, Gatter KC, Mason DY (1987) Cytokeratin expression in smooth muscle and smooth muscle tumours. Histopathology 11: 477–486PubMedGoogle Scholar
  25. Bui NB, Coindre JM, Maree D, Trojani M (1984) Liposarcoma: patterns of tumor differentiation following induction chemotherapy. Oncology 41: 170–173PubMedGoogle Scholar
  26. Buley ID, Gatter KC, Kelly PMA, Heryet A, Millard PR (1988) Granular cell tumors revisited — an immunohistochemical and ultrastructural study. Histopathology 12: 263–274PubMedGoogle Scholar
  27. Carter RJL, Jameson CF, Philip ER, Pinkerton CR (1990) Comparative phenotypes in rhabdomyosarcomas and developing skeletal muscle. Histopathology 17: 301–309PubMedGoogle Scholar
  28. Chase DR, Enzinger FM (1985) Epithelioid sarcoma — diagnosis, prognostic indicators and treatment. Am J Surg Pathol 9: 241–263PubMedGoogle Scholar
  29. Chetty R (1990) Extraskeletal mesenchymal chondrosarcoma of the mediastinum. Histopathology 17: 261–263PubMedGoogle Scholar
  30. Christensen WN, Strong EW, Bains MS, Woodruff JM (1988) Neuroendocrine differentiation in the glandular peripheral nerve sheath tumor: pathologic distinction from the biphasic synovial sarcomas with glands. Am J Surg Pathol 12: 417–426PubMedGoogle Scholar
  31. Cocchia D, Lauriola L, Stolfi VM, Tallini G, Michetti F (1983) S-100 antigen labels neoplastic cells in liposarcoma and cartilaginous tumours. Virchows Arch A 402: 139–145Google Scholar
  32. Coindre JM, de Mascarel A, Trojani M, de Mascarell I, Pages A (1988) Immunohistochemical study of rhabdomyosarcoma — unexpected staining with S100 protein and cytokeratin. J Pathol 155: 127–132PubMedGoogle Scholar
  33. Cooper CS, Stratton MR (1991) Soft tissue tumors - the genetic basis of development. Carcinogenesis 12: 155–165PubMedGoogle Scholar
  34. Cozzutto C, Comelli A, Bandelloni R (1982) Ectomesenchymoma — report of two cases. Virchows Arch A 398: 185–195Google Scholar
  35. Daimaru Y, Hashimoto H, Enjoji M (1984) Malignant “Triton” tumors: a clinicopathologic and immunohistochemical study of nine cases. Human Pathol 15: 768–778Google Scholar
  36. Daimaru Y, Hashimoto H, Enjoji M (1985) Malignant peripheral nerve-sheath tumors (malignant schwannomas). Am J Surg Pathol 9: 434–444PubMedGoogle Scholar
  37. Darbyshire PJ, Bourne SP, Allan PM, Berry J, Oakhill A, Kemshead JT, Coakham HB (1987) The use of a panel of monoclonal antibodies in pediatric oncology. Cancer 59: 726–730PubMedGoogle Scholar
  38. Dardick I, Ramjohn S, Thomas MJ, Jeans D, Hammar SP (1991) Synovial sarcoma — interrelationship of the biphasic and monophasic subtypes. Pathol Res Pract 187: 871–885PubMedGoogle Scholar
  39. Dehner LP (1988) Malignant fibrous histiocytoma: nonspecific morphologic pattern, specific pathologic entity, or both? Arch Pathol Lab Med. 112: 236–237PubMedGoogle Scholar
  40. De Lellis RA, Dayal Y (1987) The role of immunohistochemistry in the diagnosis of poorly differentiated malignant neoplasms. Sem Oncol 14: 173–192Google Scholar
  41. Dervan PA, Cahalane SF, Kneafsey P, Mynes A, McAllister K (1987) Malignant rhabdoid tumour of soft tissue — an ultrastructural and immunohistological study of a pelvic tumor. Histopathology 11: 183–190PubMedGoogle Scholar
  42. De Schryver K, Santa Gruz DJ (1984) So-called glandular schwannoma: ependymal differentiation in a case. Ultrastruct Pathol 6: 167–175Google Scholar
  43. Dias P, Kumar P, Marsden HB, Gattamaneni HR, Heighway J, Kumar S (1990) N-myc gene is amplified in alveolar rhabdomyosarcomas ( RMS) but not in embryonal RMS. Int J Cancer 45: 593–596PubMedGoogle Scholar
  44. Dias P, Parham DM, Shapiro DN, Webber BL, Houghton PJ (1990) Myogenic regulatory protein ( MyoD1) expression in childhood solid tumors — diagnostic utility in rhabdomyosarcoma. Am J Pathol 137: 1283–1291PubMedGoogle Scholar
  45. Dickersin GR (1991) Synovial sarcoma: a review and update, with emphasis on the ultra-structural characterization of the nonglandular component. Ultrastruct Pathol 15: 379–402PubMedGoogle Scholar
  46. Ding J, Hashimoto H, Enjoji M (1989) Dermatofibrosarcoma protuberans with fibrosarcomatous areas: a clinicopathologic study of nine cases and a comparison with allied tumors. Cancer 64: 721–729PubMedGoogle Scholar
  47. Donhuijsen K, Schmidt U, Metz K, Leder LD (1987) Malignant fibrous histiocytoma (MFH): hotchpotch or entity? Blut 55: 365Google Scholar
  48. Donhuijsen K, Metz K, Leder LD (1988) Desmin and S-100-protein positive malignant fibrous histiocytomas: practical and theoretical implications. Pathologe 9: 261–267PubMedGoogle Scholar
  49. Donner LR, de Lanerolle P (1990) Expression of myogenic markers in mesenchymal tumors. Lab Invest 62: 27 AGoogle Scholar
  50. Douglass EC, Valentine M, Rowe ST, Parham DM, Williams JA, Sanders JM, Houghton PJ (1990) Malignant rhabdoid tumor: a highly malignant childhood tumor with minimal karyo-type changes. Genes, Chromosomes & Cancer 2: 210–216Google Scholar
  51. Dowd JO, Laidler P (1988) Progression of dermatofibrosarcoma protuberans to malignant fibrous histiocytoma: report of a case with implications for tumor histogenesis. Human Pathol 19: 368–370Google Scholar
  52. Ducatman BS, Scheithauer BW (1984) Malignant peripheral nerve sheath tumors with divergent differentiation. Cancer 54: 1049–1057PubMedGoogle Scholar
  53. Ducatman BS, Scheithauer BW (1986) Malignant peripheral nerve sheath tumors: a clinico-pathologic study of 120 cases. Cancer 57: 2006–2021PubMedGoogle Scholar
  54. Ekfors TO, Aho HJ, Kekomaki M (1985) Malignant rhabdoid tumor of the prostatic region — immunohistochemical and ultrastructural evidence for epithelial origin. Virchows Arch A 406: 381–388Google Scholar
  55. Enjoji M, Hashimoto H (1990) Pathology of soft tissue sarcomas — selected current issues. Acta Pathol Jpn 40: 863–870PubMedGoogle Scholar
  56. Enzinger FM, Weiss SW (1988) Soft Tissue Tumors. Mosby, St LouisGoogle Scholar
  57. Eusebi V, Carcangiu ML, Dina R, Rosai J (1990) Keratin-positive epithelioid angiosarcoma of thyroid: a report of four cases. Am J Surg Pathol 14: 737–747PubMedGoogle Scholar
  58. Ferry JA, Dickersin GR (1988) Pseudoglandular schwannoma. Am J Clin Pathol 89: 546–552PubMedGoogle Scholar
  59. Fidler IJ (1978) Tumor heterogeneity and the biology of cancer invasion and metastasis. Cancer Res 38: 2651–2660PubMedGoogle Scholar
  60. Fisher C (1990) The value of electronmicroscopy and immunohistochemistry in the diagnosis of soft tissue sarcomas: a study of 200 cases. Histopathology 16: 441–454PubMedGoogle Scholar
  61. Fisher C, Schofield JB (1991) S-100 protein positive synovial sarcoma. Histopathology 19: 375–377PubMedGoogle Scholar
  62. Fisher C, Carter RL, Ramachandra S, Thomas DM (1992) Peripheral nerve sheath differentiation in malignant soft tissue tumours: an ultrastructural and immunohistochemical study. Histopathology 20: 115–125PubMedGoogle Scholar
  63. Fletcher CDM (1987) Commentary: malignant fibrous histiocytoma. Histopathology 11: 433–437PubMedGoogle Scholar
  64. Fletcher CDM (1989) Postirradiation malignant fibrous histiocytoma expressing cytokeratin: a question of diagnostic criteria. Am J Surg Pathol 13: 428–432PubMedGoogle Scholar
  65. Fletcher CDM (1990) Peripheral nerve sheath tumors: a clinicopathologic update. Pathol Annu 25: 53–74PubMedGoogle Scholar
  66. Fletcher CDM (1991) Angiomatoid malignant fibrous histiocytoma — an immunohistochemical study indicative of myoid differentiation. Human Pathol 22: 563–568Google Scholar
  67. Fletcher CDM (1992) Pleomorphic malignant fibrous histiocytoma — fact or fiction? — A critical reappraisal based on 159 tumors diagnosed as pleomorphic sarcoma. Am J Surg Pathol 16: 213–228PubMedGoogle Scholar
  68. Fletcher CDM, Beham A, Schmid C (1991a) Spindle cell haemangioendothelioma — a clinic-pathological and immunohistochemical study indicative of a non-neoplastic lesion. Histopathology 18: 291–301PubMedGoogle Scholar
  69. Fletcher CDM, Beham A, Bekir S, Clarke AMT, Marley NJE (1991b) Epithelioid angiosarcoma of deep soft tissue — a distinctive tumor readily mistaken for an epithelial neoplasm. Am J Surg Pathol 15: 915–924PubMedGoogle Scholar
  70. Freshey RI (1985) Induction of differentiation in neoplastic cells. Anticancer Res 5: 111–130Google Scholar
  71. Fu YS, Gabbiani G, Kaye GI, Lattes R (1975) Malignant soft tissue tumors of probable histiocytic origin (malignant fibrous histiocytomas): general considerations and electron microscopic and tissue culture studies. Cancer 35: 176–198PubMedGoogle Scholar
  72. Fujita TH, Okabe SH (1990) Immunohistochemical study of congenital gingival granular cell tumor (congenital epulis). J Oral Pathol Med 19: 492–496PubMedGoogle Scholar
  73. Fukada T, Tsuneyoshi M, Enjoji M (1988) Malignant fibrous histiocytoma of soft parts: an ultrastructural quantitative study. Ultrastruct Pathol 12: 117–129Google Scholar
  74. Gabbert H, Gerharz CD (1988) Differenzierungsinduktion in malignen Tumoren. Verh Dtsch Ges Path 72: 115–127Google Scholar
  75. Gabbert H, Gerharz CD, Engers R, Miiller-Klieser W, Moll R (1988) Terminally differentiated postmitotic tumor cells in a rat rhabdomyosarcoma cell line. Virchows Arch B 55: 255–261PubMedGoogle Scholar
  76. Gaffney EF (1991) Intra-abdominal neuroectodermal tumor of childhood with divergent differentiation. Histopathology 19: 390PubMedGoogle Scholar
  77. Garin-Chesa P, Fellinger EJ, Huvos AG, Beresford HR, Melamed MR, Triche TJ, Rettig EJ (1991) Immunohistochemical analysis of neural cell adhesion molecules — differential expression in small round cell tumors of childhood and adolescence. Am J Pathol 139: 275–286PubMedGoogle Scholar
  78. Garvin AJ, Stanley WS, Bennett DD, Sullivan JL, Sens DA (1986) The in vitro growth, heterotransplantation, and differentiation of a human rhabdomyosarcoma cell line. Am J Pathol 125: 208–217PubMedGoogle Scholar
  79. Gerald WL, Rosai J (1989) Desmoplastic small cell tumor with divergent differentiation. Pediatr Pathol 9: 177–183PubMedGoogle Scholar
  80. Gerharz CD, Moll R, Ramp U, Mellin W, Gabbert HE (1990a) Multidirectional differentiation in a newly established human epithelioid sarcoma cell line ( GRU-l)N with co-expression of vimentin, cytokeratin and neurofilament proteins. Int J Cancer 45: 143–152Google Scholar
  81. Gerharz CD, Moll R, Meister P, Knuth A, Gabbert HE (1990b) Cytoskeletal heterogeneity of an epithelioid sarcoma with expression of vimentin, cytokeratins and neurofilaments. Am J Surg Pathol 14: 274–283Google Scholar
  82. Giangaspero F, Fratamico FCM, Ceccarelli C (1989) Malignant peripheral nerve sheath tumors and spindle cell sarcomas: an immunohistochemical analysis of multiple markers. Appl Pathol 7: 134–144PubMedGoogle Scholar
  83. Gonzalez-Crussi F, Crawford SE, Sun CCJ (1990) Intra-abdominal desmoplastic small-cell tumors with divergent differentiation: observation on three cases of childhood. Am J Surg Pathol 14: 633–642PubMedGoogle Scholar
  84. Gonzalez-Crussi F, Chou P, Crawford SE (1991) Congenital, infiltrating giant-cell angioblastoma — a new entity. Am J Surg Pathol 15: 175–183PubMedGoogle Scholar
  85. Gould VE (1986) Histogenesis and differentiation: a re-evaluation of these concepts as criteria for the classification of tumors. Human Pathol 17: 212–215Google Scholar
  86. Gown AM, Boyd HC, Chang Y, Ferguson M, Reichler B, Tippens D (1988) Smooth muscle cells can express cytokeratins of “simple” epithelium. Am J Pathol 132: 223–232PubMedGoogle Scholar
  87. Gray MH, Rosenberg AE, Dickersin GR, Bhan AK (1989) Glial fibrillary acidic protein and keratin expression by benign and malignant nerve sheath tumors. Human Pathol 20: 1089–1096Google Scholar
  88. Hall PA, Levison DA (1989) Biphasic tumours: clues to possible histogenesis in developmental processes. J Pathol 159: 1–2PubMedGoogle Scholar
  89. Harris H, Eyden BP, Joglekar VM (1987) Rhabdoid tumour of the bladder: a histiological, ultrastructural and immunohistochemical study. Histopathology 11: 1083–1096PubMedGoogle Scholar
  90. Hasegawa T, Hirose T, Kudo E, Abe JI, Hizawa K (1990) Cytoskeletal characteristics of myofibroblasts in benign neoplastic and reactive fibroblastic lesions. Virchows Arch A 416: 375–382Google Scholar
  91. Hashimoto T, Daimaru Y, Enjoji M (1984) S-100 protein distribution in liposarcoma — an immunoperoxidase study with special reference to the distinction of liposarcoma from myxoid malignant fibrous histiocytoma. Virchows Arch A 405: 1–10Google Scholar
  92. Hashimoto T, Daimaru Y, Tsuneyoshi M, Enjoji M (1990) Soft tissue sarcoma with additional anaplastic components: a clinicopathologic and immunohistochemical study of 27 cases. Cancer 66: 1578–1589PubMedGoogle Scholar
  93. Heim S, Mandahl N, Mitelman F (1988) Genetic convergence and divergence in tumor progression. Cancer Res 48: 5911–5916PubMedGoogle Scholar
  94. Heppner GH (1984) Tumor heterogeneity. Cancer Res 44: 2259 - 2265PubMedGoogle Scholar
  95. Heppner GH (1989) Tumor cell societies. J Natl Cancer Inst 81: 648–649PubMedGoogle Scholar
  96. Heppner GH, Miller BE (1989) Therapeutic implications of tumor heterogeneity. Sem Oncol 16: 91–106Google Scholar
  97. Herrera G, Reiman BEF, Salinas JA (1982) Malignant schwannomas presenting as malignant fibrous histiocytomas. Ultrastruct Pathol 3: 253–261PubMedGoogle Scholar
  98. Hirose T, Sano T, Hizawa K (1988) Heterogeneity of malignant schwannomas. Ultrastruct Pathol 12: 107–116PubMedGoogle Scholar
  99. Hirose T, Kudo E, Hasegawa T, Abe JI, Hizawa K (1989) Expression of intermediate filaments in malignant fibrous histiocytomas. Human Pathol 20: 871–877Google Scholar
  100. Horio K, Yoshikura H, Kawabata M, Odawara T, Sudo K, Fujitani Y, Lee GH, Iwamoto A (1991) Epigenetic control of tumor cell morphology. Japan J Cancer Res 82: 676–685Google Scholar
  101. Huang JS, Huang SS, Deuel TF (1984) Transforming protein of simian sarcoma virus stimulates autocrine growth of SSV-transformed cells through PDGF cell-surface receptors. Cell 39: 79–83PubMedGoogle Scholar
  102. Hueck W (1939) Uber das Mesenchym. III. Mesenchymale Tumoren. Beitr Path Anat 103: 308–349Google Scholar
  103. Iannacone PM, Weinberg WC, Deamant FD (1987) On the clonal origin of tumors — a review of experimental models. Int J Cancer 39: 778–784Google Scholar
  104. Iwasaki H, Isayama T, Ohjimi Y, Nickuchi M, Yoh S, Shinohara N, Yoshitake K, Eshiguro M, Kamada N, Enjoji M (1992) Malignant fibrous histiocytoma — a tumor of facultative histiocytes showing mesenchymal differentiation in cultured cell lines. Cancer 69: 437–447PubMedGoogle Scholar
  105. Jabi M, Jeans D, Dardick I (1987) Ultrastructural heterogeneity in malignant fibrous histiocytoma of soft tissue. Ultrastruct Pathol 11: 583 - 592PubMedGoogle Scholar
  106. Jakate SM, Marsden HB, Ingram L (1988) Primary rhabdoid tumor of the brain. Virchows Arch A 412: 393–397Google Scholar
  107. John L, Franke WW (1989) High frequency of cytokeratin-producing smooth muscle cells in human atherosclerotic plaques. Differentiation 40: 55–62Google Scholar
  108. Johnson MD, Glick AD, David BW (1988) Immunohistochemical evaluation of Leu 7, myelin basic protein, S 100 protein, glial fibrillary acidic protein, and LN3 immunoreactivity in nerve sheath tumors and sarcomas. Arch Pathol Lab Med 112: 151–160Google Scholar
  109. Johnson TL, Lee MW, Meis JM, Zarbo RJ, Crissman (1991) Immunohistochemical characterization of malignant peripheral nerve sheath tumors. Surg Pathol 4: 121–135Google Scholar
  110. Katenkamp D (1986) Electron microscopy and immunohistochemistry in soft tissue sarcoma diagnosis — problems and limitations. 14th Int Cancer Congr, Budapest, August 21–27, Abstracts, vol 3, p 9Google Scholar
  111. Katenkamp D (1988) Cellular heterogeneity — explanation for changes of tumor phenotype and biologic behaviour in soft tissue sarcomas. Path Res Pract 183: 698–702PubMedGoogle Scholar
  112. Katenkamp D, Hünerbein R (1992) Untersuchunger zur prognostischen Bedeutung von Entzündungszellen in malignen Weichgewebstumoren des Menschen. Zugleich ein Beitrag zur Malignitätsgraduierung. Zentralbl Pathol 138: 21–25PubMedGoogle Scholar
  113. Katenkamp D, Kosmehl H (1993) Letter to the case (leiomyomatous rhabdomyosarcoma). Pathol Res Pract 189: 107–108Google Scholar
  114. Katenkamp D, Neupert G (1982) Experimental tumors with features of malignant fibrous histiocytomas. Exp Pathol 22: 11–27PubMedGoogle Scholar
  115. Katenkamp D, Raikhlin NT (1985) Stem cell concept and heterogeneity of soft tissue tumors — a challenge for diagnostics and therapy. Exp Pathol 28: 3–11PubMedGoogle Scholar
  116. Katenkamp D, Stiller D (1975) Structural patterns and histological behaviour of experimental sarcomas. II. Ultrastructural cytology. Exp Pathol 11: 190–206Google Scholar
  117. Katenkamp D, Stiller D (1990) Weichgewebstumoren. Pathologie, histologische Diagnose und Differentialdiagnose. Barth, LeipzigGoogle Scholar
  118. Katenkamp D, Stiller D, Kütter K, Möller HJ (1979) Untersuchungen zur submikroskopischen Zytologie botryoider ( Rhabdomyo-) Sarkome des Nasen-Rachens. Zbl Allg Pathol 123: 508–519Google Scholar
  119. Kawamoto EH, Weidner N, Agostini RM, Jaffe R (1987) Malignant ectomesenchymoma of soft tissue: report of two cases and review of the literature. Cancer 59: 1791–1802PubMedGoogle Scholar
  120. Kent AL, Mahoney DH, Gresik MV, Steuber CP, Fernbach DJ (1987) Malignant rhabdoid tumor of the extremity. Cancer 60: 1056–1059PubMedGoogle Scholar
  121. Klima M, Smith M, Spjut HJ, Root EN (1975) Malignant mesenchymoma — case report with electron microscopic study. Cancer 36: 1086–1094PubMedGoogle Scholar
  122. Knight JC (1990) The molecular genetics of soft tissue sarcomas. Br J Cancer 26: 511–513Google Scholar
  123. Kodet R, Kasthuri N, Marsden HB, Coad AG, Raafat F (1986) Gangliorhabdomyosarcomas: a histopathological and immunohistochemical study of three cases. Histopathology 10: 181–193PubMedGoogle Scholar
  124. Kodet R, Newton WA, Sachs N, Hamoudi AB, Raney RB, Asmar L, Gehan EA (1991a) Rhabdoid tumors of soft tissues — a clinicopathologic study of 26 cases enrolled in the intergroup rhabdomyosarcoma study. Human Pathol 22: 674–684Google Scholar
  125. Kodet R, Newton WA, Hamoudi AB, Asmar L (1991b) Rhabdomyosarcomas with intermediate- filaments inclusions and features of rhabdoid tumors — light microscopic and immunohistochemical study. Am J Surg Pathol 15: 257–267PubMedGoogle Scholar
  126. Kosmehl H, Langbein L, Katenkamp D (1990a) Transient cytokeratin expression in skeletal muscle during murine embryogenesis. Anat Anz 171: 39–44PubMedGoogle Scholar
  127. Kosmehl H, Langbein L, Katenkamp D (1990b) Experimental rhabdomyosarcoma with regions like malignant fibrious histiocytoma (MFH) — a true double phenotypic pattern? J Pathol 160: 135–140PubMedGoogle Scholar
  128. Kulesh DA, Oshima RG (1988) Cloning of human keratin 18 gene and its expression in nonepithelial mouse cells. Mol Cell Biol 8: 1540–1550PubMedGoogle Scholar
  129. Lagace R (1987) The ultrastructural spectrum of malignant fibrous histiocytoma. Ultrastruct Pathol 11: 153–159PubMedGoogle Scholar
  130. Langbein L, Kosmehl H, Katenkamp D (1988) Intermediate filament typing in tumour diagnostics — an aid in histogenetic classification? Acta Morph Hung 36: 215–225Google Scholar
  131. Langbein L, Kosmehl H, Katenkamp D, Neupert G, Stiller KJ (1990) Experimentally induced rhabdomyosarcomas — correlation between cellular contacts, matrix formation and cellular differentiation. Differentiation 44: 185–196PubMedGoogle Scholar
  132. Layfield LJ, Lenarsky C (1991) Desmoplastic small cell tumors of the peritoneum coexpressing mesenchymal and epithelial markers. Am J Clin Pathol 96: 536–543PubMedGoogle Scholar
  133. Leader M, Collins M, Patel J, Henry K (1987) Desmin: its value as a marker of muscle derived tumours using a commercial antibody. Virchows Arch A 411: 345–349Google Scholar
  134. Leith JT, Dexter DL (1986) Mammalian tumor cell heterogeneity. CRC Press, Bocan RatonGoogle Scholar
  135. Leu HJ, Makek M (1982) Angiomatoid malignant fibrous histiocytoma — case report and electron microscopic findings. Virchows Arch A 395: 99–107Google Scholar
  136. Llombart-Bosch A, Carda C, Boix J, Pellin A, Peydro-Olaya A (1988) Value of nude mice xenografts in the expression of cell heterogeneity of human sarcomas of bone and soft tissue. Path Res Pract 183: 683–692PubMedGoogle Scholar
  137. Lodding P, Kindblom LG, Angervall L, Stenman G (1990) Cellular schwannoma — a clinic pathologic study of 29 cases. Virchows Arch A 416: 237–248Google Scholar
  138. Lollini PL, Degiovanni D, Delre B, Landuzzi L, Nicoletti G, Prodi G, Scotlandi K, Nanni (1989) Myogenic differentiation of human rhabdomyosarcoma cells induced in vitro by antineoplastic drugs. Cancer Res 49: 3631–3636PubMedGoogle Scholar
  139. Matias C, Nunes JFM, Vicente LF, Almeida MO (1990) Primary malignant rhabdoid tumor of the vulva. Histopathology 17: 576–578PubMedGoogle Scholar
  140. Matthews MJ, Gazdar AF (1985) Changing histology in malignant tumors: diagnostic and therapeutic significance. Eur J Cancer Clin Oncol 21: 549–552PubMedGoogle Scholar
  141. McGregor DH, Dixon AY, Moral L, Kanabe S (1987) Liposarcoma of pleural cavity with recurrence as malignant fibrous histiocytoma. Ann Clin Lab Sci 17: 83–92PubMedGoogle Scholar
  142. McWilliam LJ, Harris M (1985) Granular cell angiosarcoma of the skin: histology, electron microscopy and immunohistochemistry of a newly recognized tumour. Histopathology 9: 1205–1216PubMedGoogle Scholar
  143. Meis JM, Enzinger FM (1991) Inflammatory fibrosarcoma of the mesentery and retroperitoneum — a tumor loosely simulating inflammatory pseudotumor. Am J Surg Pathol 15: 1146–1156PubMedGoogle Scholar
  144. Meister P (1988) Malignant fibrous histiocytoma — history, histology, histogenesis. Path Res Pract 183: 1–7PubMedGoogle Scholar
  145. Meister P (1991) Weichgewebstumoren: Definition, Klassifizierung und Graduierung. 27. Symposium der Int. Akademie fur Pathologie, Deutsche Abtlg. e.V., Bonn, Februar 1991Google Scholar
  146. Mentzel T, Kosmehl H, Katenkamp D (1991) Metastasizing phyllodes tumour with malignant fibrous histiocytoma-like areas. Histopathology 19: 557–560PubMedGoogle Scholar
  147. Mierau GW, Berry FJ, Orsini EN (1985) Small round cell neoplasms: can electron microscopy and immunohistochemical studies accurately classify them? Ultrastruct Pathol 9: 99–111PubMedGoogle Scholar
  148. Miettinen M (1988a) Immunoreactivity for cytokeratin and epithelial membrane antigen in leiomyosarcomas. Arch Pathol Lab Med 112: 637–640PubMedGoogle Scholar
  149. Miettinen M (1988b) Antibody specific to muscle actins in the diagnosis and classification of soft tissue tumors. Am J Pathol 130: 205–215PubMedGoogle Scholar
  150. Miettinen M (1989) Intermediate filament proteins in soft tissue sarcomas: new findings suggest a complex pattern of expression. In: Osborn M, Weber K (eds) Cytoskeletal proteins in tumor diagnosis. Cold Spring Harbor Lab, New York, pp 63–68Google Scholar
  151. Miettinen M (1990) Immunohistochemistry of solid tumours. Brief review of selected problems. APMIS 98: 191–199PubMedGoogle Scholar
  152. Miettinen M (1991) Keratin subsets in spindle cell sarcomas — keratins are widespread but synovial sarcomas contain a distinctive keratin polypeptide pattern and desmoplakins. Am J Pathol 138: 505–513PubMedGoogle Scholar
  153. Miettinen M, Kovatich A (1991) Keratins in soft tissue sarcomas — common phenomenon or technical artifact? Am J Clin Pathol 96: 673–674PubMedGoogle Scholar
  154. Miettinen M, Rapola J (1989) Immunohistochemical spectrum of rhabdomyosarcoma and rhabdomyosarcoma-like tumors — expression of cytokeratin and 68-kD neurofilament protein. Am J Surg Pathol 13: 120–132PubMedGoogle Scholar
  155. Miettinen M, Soini Y (1989) Malignant fibrous histiocytoma — heterogeneous patterns of intermediate filament proteins by immunohistochemistry. Arch Pathol Lab Med 113: 1363–1366PubMedGoogle Scholar
  156. Miettinen M, Lehto VP, Badley RA, Virtanen I (1982) Expression of intermediate filaments in soft-tissue sarcomas. Int J Cancer 30: 541–546PubMedGoogle Scholar
  157. Miettinen M, Foidart JM, Ekblom P (1983) Immunohistochemical demonstration of laminin, the major glycoprotein of basement membranes, as aid in the diagnosis of soft tissue tumors. Am J Clin Pathol 73: 306–311Google Scholar
  158. Mirra JM, Kessler S, Bhuta S, Eckardt J (1992) The fibroma-like variant of epithelioid sarcoma — a fibrohistiocytic/myoid cell lesion often confused with benign and malignant spindle cell tumors. Cancer 69: 1382–1395PubMedGoogle Scholar
  159. Molenaar WM, Oosterhuis JW, Kamps WA (1984) Cytologic “differentiation” in childhood rhabdomyosarcomas following polychemotherapy. Human Pathol 15: 973–979Google Scholar
  160. Molenaar WM, Dam-Meiring A, Kamps WA, Cornelisse CJ (1988) DNA-aneuploidy in rhabdomyosarcomas as compared with other sarcomas of childhood and adolescence. Human Pathol 19: 573–579Google Scholar
  161. Molenaar WM, deJong B, Buist J, Idenburg VJS, Seruca R, Vos AM, Hoekstra HJ (1989a) Chromosomal analysis and the classification of soft tissue sarcomas. Lab Invest 60: 266–274Google Scholar
  162. Molenaar WM, deJong B, Dam-Meiring A, Postma A, Hoekstra HJ (1989b) Epithelioid sarcoma or malignant rhabdoid tumor of soft tissue? Epithelioid immunophenotype and rhabdoid karyotype. Human Pathol 20: 347–351Google Scholar
  163. Moll R, Lee I, Gould VE, Berndt R, Roessner A, Franke WW (1987) Immunohistochemical analysis of Ewing’s tumors — pattern of expression of intermediate filaments and desmosomal proteins indicate cell type heterogeneity and pluripotential differentiation. Amer J Pathol 127: 288–304Google Scholar
  164. Nakashima Y, Unni KK, Shives TC, Swee RG, Dahlin DC (1986) Mesenchymal chondrosarcoma of bone and soft tissue: a review of 111 cases. Cancer 57: 2444–2453PubMedGoogle Scholar
  165. Nakazato Y, Hirato J, Nakanishi Y, Tamaki O, Yazaki C (1991) Immunohistochemical localization of five classes of intermediate filaments in a benign pelvic soft tissue tumor of rhabdoid appearance. Acta Pathol Jpn 41: 65–72PubMedGoogle Scholar
  166. Newman PL, Fletcher CDM (1987) Malignant mesenchymoma — clinicopathologic analysis of a series with evidence of low-grade behaviour. Am J Surg Pathol 15: 607–614Google Scholar
  167. Nicolson GL (1987) Tumor cell instability, diversification, and progression to the metastatic phenotype: from oncogene to oncofetal expression. Cancer Res 47: 1473–1487PubMedGoogle Scholar
  168. Norton AJ, Thomas JA, Isaacson PG (1987) Cytokeratin-specific monoclonal antibodies are reactive with tumours of smooth muscle derivation — an immunohistochemical and biochemical study using antibodies to intermediate filament cytoskeletal proteins. Histopathology 11: 487–499PubMedGoogle Scholar
  169. O’Dowd J, Laidler P (1988) Progression of dermatofibrosarcoma protuberans to malignant fibrous histiocytoma: report of a case with implications for tumor histogenesis. Human Pathol 19: 368–370Google Scholar
  170. Ohmori T, Arita N, Sano A, Watanabe Y (1986) Malignant fibrous histiocytoma showing cytoplasmic hyaline globules and stromal osteoids — a case report with light and electron microscopic, histochemical and immunohistochemical study. Acta Pathol Jpn 36: 1931–1941PubMedGoogle Scholar
  171. Okabe T, Suzuki A, Hirono M, Tamaoki N, Oshimura M, Takaku F (1983) Establishment of different clonal strains from a human sarcoma of the stomach: tumorigenic heterogeneity in athymic nude mice. Cancer Res 43: 5456–5461PubMedGoogle Scholar
  172. Ordonez NG, Mahfouz SM, MacKay B (1990) Synovial sarcoma - an immunohistochemical and ultrastructural study. Human Path 21: 733–749Google Scholar
  173. Otto HF, Berndt R, Schwechheimer K, Moller P (1987) Mesenchymal tumor markers: special proteins and enzymes. Current Topics Pathol 77: 197–205Google Scholar
  174. Palman G, Bowenpope DF, Brooks JJ (1992) Plastelet-derived growth factor receptor (beta-subunit) immunoreactivity in soft tissue tumors. Lab Invest 66: 108–115PubMedGoogle Scholar
  175. Palmer NF, Sutow W (1983) Clinical aspects of the rhabdoid tumor of the kidney: a report of the National Wilm’s Tumor Study Group. Med Pediatr Oncol 11: 242–245PubMedGoogle Scholar
  176. Parham DM, Jenkins JJ, Holt H, Callihan TR (1987) Phenotypic diversity in pediatric rhabdoid tumors: a morphologic and immunohistochemical study. Lab Invest 56: 58AGoogle Scholar
  177. Parham DM, Webber B, Holt H, Williams WK, Maurer H (1991) Immunohistochemical study of childhood rhabdomyosarcomas and related neoplasms — results of an intergroup Rhabdomyosarcoma Study project. Cancer 67: 3072–3080PubMedGoogle Scholar
  178. Perosio PM, Brooks J J (1989) Expression of growth factor receptors in soft tissue tumors — implications for the autocrine hypothesis. Lab Invest 60: 245–253PubMedGoogle Scholar
  179. Perrone T, Swanson PE, Twiggs L, Ulbright TM, Dehner LP (1989) Malignant rhabdoid tumor of the vulva: is distinction from epithelioid sarcoma possible? A pathologic and immunohistochemical study. Am J Surg Pathol 13: 848–858PubMedGoogle Scholar
  180. Pettinato G, Manivel JC, De Rosa G, Petrella G, Jaszcz W (1990) Angiomatoid malignant fibrous histiocytoma: cytologic, immunohistochemical, ultrastructural and flow cytometric study of 20 cases. Mod Pathol 3: 479–487PubMedGoogle Scholar
  181. Pitot HC (1989) Progression: the terminal stage in carcinogenesis. Jpn Cancer Res 80: 599–607Google Scholar
  182. Porter PL, Gown AM, Kramp SG, Coltrera MD (1992) Widespread p53 overexpression in human malignant tumors. Am J Pathol 140: 145–153PubMedGoogle Scholar
  183. Radio SE, Woolridge TN, Lindner J (1988) Flow cytometric DNA analysis of malignant fibrous histiocytoma and related fibrohistiocytic tumors. Human Pathol 19: 74–77Google Scholar
  184. Raju GC, O’Reilly AP (1987) Immunohistochemical study of granular cell tumour. Pathology 19: 402–406PubMedGoogle Scholar
  185. Ramaekers FC, Pruszczynski M, Smedts F (1988) Cytokeratins in smooth muscle cell and smooth muscle tumours. Histopathology 12: 558–561PubMedGoogle Scholar
  186. Ro JY, Ayala AG, Sella A, Samuels ML, Swanson DA (1987) Sarcomatoid renal cell carcinoma: a clinicopathologic study of 42 cases. Cancer 59: 516–526PubMedGoogle Scholar
  187. Roholl PJM, deJong ASH, Albus-Lutter CE, Ramaekers FCS (1985) Application of markers in the diagnosis of soft tissue tumours. Histopathology 9: 1019–1035PubMedGoogle Scholar
  188. Roholl PJM, deJong ASH, Albus-Lutter CE, van Unnik JAM (1988a) Leiomyosarcomas: the three cases with desmin positive tumour cells, lacking ultrastructural features of smooth muscle cells. Histol Histopathol 3: 389–394Google Scholar
  189. Roholl PJM, Rutgers DH, Ramaekers FCS, De Weger RA, Elbers JRJ, van Unnik JAM (1988b) Characterization of human soft tissue sarcomas in nude mice: evidence for histogenetic properties of malignant fibrous histiocytomas. Am J Pathol 131: 559–568Google Scholar
  190. Roholl PJM, Elbers JRJ, Prinsen I, van Unnik JAM (1990a) Distribution of actin isoforms in sarcomas — an immunohistochemical study. Human Pathol 21: 1269–1274Google Scholar
  191. Roholl PJM, Skottner A, Prinsen I, Lips CJM, Den Otten W, van Unnik JAM (1990b) Expression of insulin-like growth factor 1 in sarcomas. Histopathology 16: 455–460Google Scholar
  192. Roholl PJM, Weima SM, Prinsen I, Ramaekers LPHM, Hsu SM, van Unnik JAM (1991a) Two cell lines with epithelial cell-like characteristics established from malignant fibrous histocytomas. Cancer 68: 1963–1972Google Scholar
  193. Roholl PJM, Weima SM, Prinsen I, De Weger RA, Den Otten W, van Unnik JAM (1991b) Expression of growth factors and their receptors in human sarcomas. Immunohistochemical detection of platelet-derived growth factor, epidermal growth factor and their receptors. Cancer J 4: 83–88Google Scholar
  194. Rubin H (1990) The significance of biological heterogeneity. Cancer Metastasis Rev 9: 1–20PubMedGoogle Scholar
  195. Schmidt D, Harms D (1987) Epithelioid sarcoma in children and adolescents — an immuno-histochemical study. Virchows Arch A 410: 423–431Google Scholar
  196. Schmidt D, Steen A, Voss C (1989a) Immunohistochemical study of rhabdomyosarcoma: unexpected staining with S-100 protein and cytokeratin. J Pathol 157: 83Google Scholar
  197. Schmidt D, Leuschner I, Harms D, Sprenger E, Schafer HJ (1989b) Malignant rhabdoid tumor — a morphological and flow cytometric study. Path Res Pract 184: 202–210PubMedGoogle Scholar
  198. Schmidt D, Leuschner I, Moeller R, Harms D (1990a) Immunohistochemische Befunde bei Rhabdomyosarkomen. Pathologe 11: 283–289PubMedGoogle Scholar
  199. Schmidt D, Harms D, Leuschner I (1990b) Cytokeratin expression in malignant Triton tumor. Path Res Pract 186: 507–511PubMedGoogle Scholar
  200. Schmidt D, Herrmann C, Jiirgens H, Harms D (1991) Malignant peripheral neuroectodermal tumor and its necessary distinction from Ewing’s sarcoma — a report from the Kiel Pediatric Tumor Registry. Cancer 68: 2251–2259PubMedGoogle Scholar
  201. Schmitt FC, Bacchi CE (1989) S-100 protein: is it useful as tumour marker in diagnostic immunohistochemistry? Histopathology 15: 281–288PubMedGoogle Scholar
  202. Schroder S, Tessmann D (1991) Maligner desmoplastischer kleinzelliger Tumor des Peritoneums mit divergenter Differenzierung. Pathologe 12: 334–340PubMedGoogle Scholar
  203. Schiirch W, Skalli O, Seemayer TA, Gabbiani G (1987) Intermediate filament proteins and actin isoforms as markers for soft tissue tumor differentiation and origin. I. Smooth muscle tumors. Am J Pathol 128: 91–103Google Scholar
  204. Schiirch W, Skalli O, Lagace R, Seemayer TA, Gabbiani G (1990) Intermediate filament proteins and actin isoforms as markers for soft tissue tumor differentiation and origin. 3. Hemangiopericytomas and glomus tumors. Am J Pathol 136: 771–786Google Scholar
  205. Scrable H, Witte D, Shimada H, Seemayer TA, Wang-Wuu S, Soukup S, Koufos A, Houghton P, Lampkin B, Cavenee W (1989) Molecular differentiation pathology of rhabdomyosarcoma. Genes Chromosomes Cancer 1: 23–35PubMedGoogle Scholar
  206. Seo IS, Warner TFCS, Warren JS, Bennett JE (1985) Cutaneous postirradiation sarcoma — ultrastructural evidence of pluripotential mesenchymal cell derivation. Cancer 56: 761–767PubMedGoogle Scholar
  207. Shmookler BM, Enzinger FM, Weiss SW (1989) Giant cell fibroblastoma: a juvenile form of dermatofibrosarcoma protuberans. Cancer 64: 2154–2161PubMedGoogle Scholar
  208. Skalli O, Gabbiani G, Babai F, Seemayer TA, Pizzolato G, Schürch W (1988) Intermediate filament proteins and actin isoforms as markers for soft tissue tumor differentiation and origin: II. Rhabdomyosarcoma. Am J Pathol 130: 515–531PubMedGoogle Scholar
  209. Smith MEF, Costa MJ, Weiss SW (1991) Evaluation of CD68 and other histiocytic antigens in angiomatoid malignant fibrous histiocytoma. Am J Surg Pathol 15: 757–763PubMedGoogle Scholar
  210. Snover DC, Sumner HW, Dehner LP (1982) Variability of histologic pattern in recurrent soft tissue sarcomas originally diagnosed as liposarcoma. Cancer 49: 1005–1015PubMedGoogle Scholar
  211. Soini Y, Autio-Harmainen H (1991) Tumor cells of malignant fibrous histiocytomas express mRNA for laminin. Am J Pathol 139: 1061–1067PubMedGoogle Scholar
  212. Soini Y, Miettinen M (1991) Immunohistochemistry of markers of histiomonocytic cells in malignant fibrous histiocytomas — a monoclonal antibody study. Path Res Pract 186: 759–767Google Scholar
  213. Stenman G, Kindblom LG, Willems J, Angervall L (1990) A cell culture, chromosomal arid quantitative DNA analysis of a metastatic epithelioid sarcoma: deletion lp. a possible primary chromosomal abnormality in epithelioid sarcoma. Cancer 65: 2006–2013PubMedGoogle Scholar
  214. Stratton MR, Moss S, Warren W, Patterson H, Clark J, Fisher C, Fletcher CDM, Ball A, Thomas M, Gusterson BA, Cooper CS (1990) Mutation of p53 gene in human soft tissue sarcomas: association with abnormalities of the RBI gene. Oncogene 5: 1297–1301PubMedGoogle Scholar
  215. Strauchen JA, Dimitriu-Bona A (1986) Malignant fibrous histiocytoma — expression of monocyte/macrophage differentiation antigens detected with monoclonal antibodies. Am J Pathol 124: 303–309PubMedGoogle Scholar
  216. Swanson PE (1991) Heffalumps, jagulars, and Cheshire cats - a commentary on cytokeratins and soft tissue sarcomas. Am J Clin Pathol 95 (Suppl I): S2 - S7PubMedGoogle Scholar
  217. Swanson PE, Manivel JC, Wick MR (1987) Immunoreactivity for Leu-7 in neurofibrosarcoma and other spindle cell sarcomas of soft tissue. Am J Pathol 126: 546–560PubMedGoogle Scholar
  218. Swanson PE, Dehner LP, Wick MR (1988) Polyphenotypic small cell tumors of childhood. Lab Invest 68: 9PGoogle Scholar
  219. Takahara O, Nakayama I, Yokoyama S, Moriuchi A, Muta H, Uchida Y (1979) Malignant neurofibroma with glandular differentiation (glandular schwannoma). Acta Pathol Jpn 40: 597–606Google Scholar
  220. Takizawa T, Matsui T, Maeda Y, Okabe S, Mochizuki M, Tanaka A, Kawaguchi K, Fukayama M, Funata N, Koike M, Mastuda T (1989) X-radiation-induced differentiaton of xenotrans-planted human undifferentiated rhabdomyosarcoma. Lab Invest 69: 22–29Google Scholar
  221. Tanimura A, Nagayama K, Nakamura Y, Tanaka S, Tanaka T (1985) Malignant fibrous histiocytoma with granular cells, mimicking a granular cell tumor — light, electron microscopic and immunohistochemical observations of a case. Acta Pathol Jpn 35: 1555–1560PubMedGoogle Scholar
  222. Tauchi K, Tsutsumi Y, Yoshimura S, Watanabe K (1990) Immunohistochemical and immuno-blotting detection of cytokeratin in smooth muscle tumours. Acta Pathol Jpn 40: 574–580PubMedGoogle Scholar
  223. Tsokos M, Kouraklis G, Chandra RS, Bhagavan BS, Triche TJ (1989) Malignant rhabdoid tumor of the kidney and soft tissues — evidence for a diverse morphological and immuno- cytochemical phenotype. Arch Pathol Lab Med 113: 115–120PubMedGoogle Scholar
  224. Tsuneyoshi M, Daimaru Y, Hashimoto H, Enjoji M (1987) The existence of rhabdoid cells in specified soft tissue sarcomas. Virchows Arch A 411: 509–514Google Scholar
  225. Ulrich J, Heitz PU, Fischer T, Obrist E, Gullotta F (1987) Granular cell tumors: evidence for heterogeneous tumor cell differentiation — an immunohistochemical study. Virchows Arch B 53: 52–57PubMedGoogle Scholar
  226. Uri AK, Witzleben CL, Raney RB (1984) Electron microscopy of glandular schwannoma. Cancer 53: 493–497PubMedGoogle Scholar
  227. Uriel J (1979) Retrodifferentiation and fetal patterns of gene expression in cancer. Adv Cane Res 29: 127–174Google Scholar
  228. van Haelst UGJM, Pruszcznski M, Cate LN, Mravunac M (1990) Ultrastructural and immuno-histochemical study of epithelioid hemangioendothelioma of bone: coexpression of epithelial and endothelial markers. Ultrastruct Pathol 14: 141–149PubMedGoogle Scholar
  229. Weeks DA, Beckwith JB, Mierau CW (1989) Rhabdoid tumor — an entity or a phenotype? Arch Pathol Lab Med 113: 113–114PubMedGoogle Scholar
  230. Weiss SW, Enzinger FM (1986) Spindle cell hemangioendothelioma: a low-grade angiosarcoma resembling a cavernous hemangioma and Kaposi’s sarcoma. Am J Surg Pathol 10: 521–530PubMedGoogle Scholar
  231. Weiss SW, Bratthauer GL, Morris PA (1988) Postirradiation malignant fibrous histiocytoma expressing cytokeratin — implications for the immunodiagnosis of sarcomas. Am J Surg Pathol 12: 554–558PubMedGoogle Scholar
  232. Wick MR, Swanson PE, Scheithauer BW, Manivel JC (1987) Malignant peripheral nerve sheath tumor: an immunohistochemical study of 62 cases. Am J Clin Pathol 87: 425–433PubMedGoogle Scholar
  233. Wich MR, Manivel JC, Swanson PE (1988) Contributions of immunohistochemical analysis to the diagnosis of soft tissue tumors: a review. Progr Surg Pathol 8: 197–249Google Scholar
  234. Wong SY, Teh M, Tan YO, Best PV (1991) Malignant glandular Triton tumors. Cancer 67: 1076–1081PubMedGoogle Scholar
  235. Woodruff JM (1976) Peripheral nerve tumors showing glandular differentiation (glandular schwannomas). Cancer 37: 2399–2413PubMedGoogle Scholar
  236. Wrotnowski U, Cooper PH, Shmookler BM (1988) Fibrosarcomatous change in dermatofibro-sarcoma protuberans. Am J Surg Pathol 12: 287–293PubMedGoogle Scholar
  237. Xiang JH, Spanier SS, Bensen NA, Braylan RC (1987) Flow cytometric analysis of DNA in bone and soft tissue tumors using nuclear suspensions. Cancer 59: 1951–1958PubMedGoogle Scholar
  238. Zoltie N, Roberts PF (1989) Spindle cell haemangioendothelioma in association with epithelioid haemangioendothelioma. Histopathology 15: 544–546PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1995

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  • H. Kosmehl

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