Heterogeneity in Malignant Soft Tissue Tumors

  • H. Kosmehl
Part of the Current Topics in Pathology book series (CT PATHOLOGY, volume 89)


Heterogeneity exists in all tumors and should thus be acknowledged as a fundamental and inherent characteristic of soft tissue tumors as well. As all pathologists know from their diagnostic work, particularly malignant soft tissue tumors may show marked heterogeneity at the morphological and/or functional level (Fidler 1978; Heppner 1984; Katenkamp 1988; Rubin 1990). The term heterogeneity as applied here can be defined as a diversity of cellular and structural features and functional determinants. This is not identical with the term “heterogeneity” used by biologists who define it with clonality only, i.e., in a heterogeneous tumor there must occur at least two different cell clones. In contrast, we use a more comprehensive definition and include all phenomena of both interclonal differences and intraclonal variabilites (compare Heppner 1984; Heppner and Miller 1989).


Soft Tissue Sarcoma Synovial Sarcoma Soft Tissue Tumor Malignant Peripheral Nerve Sheath Tumor Malignant Fibrous Histiocytoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 1995

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  • H. Kosmehl

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