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Leiomyosarcoma

  • A. O. Cavazzana
  • V. Ninfo
  • R. Tirabosco
  • A. Montaldi
  • R. Frunzio
Part of the Current Topics in Pathology book series (CT PATHOLOGY, volume 89)

Abstract

Malignant tumors of smooth muscle origin are one of the more frequent sarcomas; their relative frequency has been estimated from 2% (Myhre-Jensen et al. 1983; Trojani et al. 1984) to 8.8% (Enjoji and Hashimoto 1984) — 9.3% (Markhede et al. 1982) of all soft tissue sarcomas. The annual incidence of leiomyosarcoma (LMS) is calculated to be 1.136 per million for whites and 1.984 per million for blacks regardless of the sites of origin (Polednak 1986). According to the same source, LMS also represents the most frequent sarcoma with a frequency of 30% in whites and 39% in blacks.

Keywords

Synovial Sarcoma Nerve Sheath Tumor Granular Cell Neoplasm Smooth Muscle Tumor Uterine Leiomyomas 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Agarwal V, Greenebaum E, Wersto R, Koss LG (1991) DNA plody of spindle cell soft-tissue tumors and its relationship to histology and clinical outcome. Arch Pathol Lab Med 6: 558–562Google Scholar
  2. Atkin NB, Kay R (1979) Prognostic significance of modal DNA value and other factors in malignant tumors, based on 1.465 cases. Br J Cancer 40: 210–220PubMedCrossRefGoogle Scholar
  3. Bearman RM (1974) Primary leiomyosarcoma of the hearth. Report of a case and review of the literature. Arch Pathol 98: 62–65PubMedGoogle Scholar
  4. Boghosian L, dal Cin P, Turc-Carel C, Rao U, Karakousis C, Sait SJ, Sandberg AA (1989) Three possible cytogenetic subgroups of leiomyosarcoma. Cancer Genet Cytogenet 43: 39–49PubMedCrossRefGoogle Scholar
  5. Brooks J J (1986) The significance of double phenotypic patterns and markers in human sarcomas. A novel model of mesemchymal differentiation. Am J Pathol 125: 113–123PubMedGoogle Scholar
  6. Brown AL, Graham DE, Nissley SP, Hill DJ, Strain AJ, Rechler MM (1986) Developmental regulation of insulin-like growth factor II mRNA in different rat tissues. J Biol Chem 261: 13144–13150PubMedGoogle Scholar
  7. Brown DC, Theaker JM, Banks PM, Gatter KC, Mason DY (1987) Cytokeratin expression in smooth muscle and smooth muscle tumours. Histopathology 11: 477–486PubMedCrossRefGoogle Scholar
  8. Cavazzana AO, Tirabosco R, Frunzio R, Scalerta R, Panozzo M, Schiaroli S, Rossi R, Lise M, Ninfo V, Spagnoli LG (1992) IGF-II correlates with tumor differentiation and not with tumor progression in malignant smooth muscle tumors. Patologia 25: 3 (8A)Google Scholar
  9. Dahl I, Angervall L (1974) Cutaneous and subcutaneous leiomyosarcoma: a clinicopathologic study of 47 patients. Pathol Eur 9: 307–315PubMedGoogle Scholar
  10. Enjoji M, Hashimoto H (1984) Diagnosis of soft tissue sarcomas. Pathol Res Pract 178: 215–226PubMedCrossRefGoogle Scholar
  11. Evans HL (1985) Smooth muscle tumors of the gastrointestinal tract. A study of 56 cases followed for a minumum of 10 years. Cancer 56: 2242–2250PubMedCrossRefGoogle Scholar
  12. Fisher C (1990) The value of electronmicroscopy and immunohistochemistry in the diagnosis of soft tissue sarcomas: a study of 200 cases. Histopathology 16: 441–454PubMedCrossRefGoogle Scholar
  13. Fletcher C (1992) Pleomorphic malignant fibrous histiocytoma: fact or fiction?: a critical reappraisal based on 159 tumors diagnosed as pleomorphic sarcoma. Am J Surg Pathol 16: 213–228PubMedCrossRefGoogle Scholar
  14. Fletcher JA, Morton CC, Pavelka K, Lage JM (1990) Chromosome aberrations in uterine smooth muscle tumors: potential diagnostic relevance of cytogenetic instability. Cancer Res 50: 4092–4097PubMedGoogle Scholar
  15. Franke WW, Grund C, Kuhn C, Jackson BW, Illmensee K (1982) Formation of cytoskeleton of elements during mouse embryogenesis. III. Prymary mesenchymal cells and the first appearance of vimentin filaments. Differentiation 23: 4349Google Scholar
  16. Froesch ER, Schmid C, Schwander J, Zapf J (1985) Actions of insulin-like growth factors. Annu Rev Physiol 47: 443–467PubMedCrossRefGoogle Scholar
  17. Gabbiani G, Schmid E, Winter S, Chaponier C, de Chastonay C, Vandekerckhove J, Weber K, Franke WW (1981) Vascular smooth muscle cells differ from other smooth muscle cells: predominance of vimentin filaments and a specific alpha-typeactin. Proc Natl Acad Sci USA 78: 298–302PubMedCrossRefGoogle Scholar
  18. Gloudemans T, Prinsen I, van Unnik JA, Lips CJ, den Otter W, Sussenbach JS (1990) Insulin-like growth factor gene expression in human smooth muscle tumors. Cancer Res 50: 6689–6695PubMedGoogle Scholar
  19. Gray A, Tam AW, Dull TJ, Hayffick J, Pintar J, Cavanee WK, Koufos A, Ullrich A (1987) Tissue-specific and developmentally regulated transcription of the insulin-like growth factor 2 gene. DNA 6: 283–295PubMedCrossRefGoogle Scholar
  20. Hashimoto H, Daimaru Y, Tsuneyoshi M, Enjoji M (1986) Leiomyosarcoma of the external soft tissues. A clinicopathologic, immunohistochemical, and electron microscopic study. Cancer 57: 2077–2088PubMedCrossRefGoogle Scholar
  21. Hayashi T, Shimada O, Anami M, Karasuyama M, Sato N, Muraoka N, Tsuda N (1990) Histogenesis of the clear cytoplasm in the tumor cells of the smooth muscle origin. Rinsho Byori 3: 317–322Google Scholar
  22. Heim S, Nilbert M, Vanni R, Floderus U-M et al. (1988) A specific translocation, t(12;14) (q14–15;q23–24), characterizes a subgroup of uterine leiomyomas. Cancer Genet Cytogenet 32: 13–17PubMedCrossRefGoogle Scholar
  23. Hendrickson MR, Kempson RL (1991) The uterine corpus. In: Sternberg SS, Mills SE (eds) Surgical pathology of the female reproductive system and peritoneum. Raven, New YorkGoogle Scholar
  24. Hoppener JWM, Mosselman S, Roholl PJM, Lambrechts C, Slebos RJC, de Pagter-Holthuizen P, Lips CJM, Jansz HS, Sussenbach JS (1988) Expression of insulin-like growth factor-I and — II genes in human smooth muscle tumors. EMBO J 7: 1379–1385PubMedGoogle Scholar
  25. Jones H, Steart PV, du Bolay CEH, Roche WR (1990) Alpha-smooth muscle actin as marker for soft tissue tumours: a comparison with desmin. J Pathol 126: 29–33CrossRefGoogle Scholar
  26. Kiyabu MT, Bishop PC, Parker JW, Turner RR, Fitzgibbons PL (1988) Smooth muscle tumors of the gastrointestinal. Flow cytometric quantification of DNA and nuclear antigen content and correlation with histologic grade. Am J Surg Pathol 12: 954–960PubMedCrossRefGoogle Scholar
  27. Knapp AC, Franke WW (1989) Spontaneous losses of control of cytokeratin gene expression in transformed, non-epithelial human cells occurring at different levels of regulation. Cell 59: 67–79PubMedCrossRefGoogle Scholar
  28. Knapp RH, Wick MR, Goeller JR (1984) Leiomyoblastoma and their relationship to other smooth-muscle tumors of the gastrointestinal tract. Am J Surg Pathol 8: 449–461PubMedCrossRefGoogle Scholar
  29. Kroese MC, Rutgers DH, Wils IS, van Unnik JA, Roholl PJ (1990) The relevance of the DNA index and proliferation rate in the grading of the benign and malignant soft tissue tumors. Cancer 8: 1782–1788CrossRefGoogle Scholar
  30. Kuruc N, Franke WW (1988) Transient coexpression of desmin and cytokeratin 8 and 18 in developing myocardial cells of some vertebrate species. Differentiation 38: 177–193PubMedCrossRefGoogle Scholar
  31. Lazarides E (1980) Intermediate filaments as mechanical integrators of cellular space. Nature 283: 249–256PubMedCrossRefGoogle Scholar
  32. LeBoit PE, Barr RJ, Burall S, Metcalf JS, Yen TS, Wick MR (1991) Primitive polypoid granular-cell tumor and other cutaneous granular-cell neoplasms of apparent nonneural origin. Am J Surg Pathol 1: 48–58CrossRefGoogle Scholar
  33. Maillet MW, Robinson RA, Burgart LJ (1992) Genomic alterations in sarcomas: a histologic correlative study with use of oncogene panels. Mod Pathol 5: 410–414PubMedGoogle Scholar
  34. Markhede G, Angervall L, Stener B (1982) A multivariate analysis of the prognosis after surgical treatment of malignant of malignant soft-tissue tumors. Cancer 49: 1721–1733PubMedCrossRefGoogle Scholar
  35. Miettinen M (1988a) Antibody specific to muscle actins in the diagnosis and classification of soft tissue tumors. Am J Pathol 130: 205–215PubMedGoogle Scholar
  36. Miettinen M (1988b) Immunoreactivity for cytokeratin and epithelial membrane antigen in leiomyosarcoma. Arch Pathol Lab Med 112: 637–640PubMedGoogle Scholar
  37. Miettinen M (1991) Keratin subsets in spindle cell sarcomas. Keratins are widespread but synovial sarcoma contains a distinctive keratin polypeptide pattern and desmoplakins. Am J Pathol 138: 505–513PubMedGoogle Scholar
  38. Miettinen M, Foidart J, Ekblom P (1983) Immunohistochemical demonstration of laminin, the major glycoprotein ofbasement membranes, as an aid in the diagnosis of soft tissue tumors. Am J Clin Pathol 79: 306–311PubMedGoogle Scholar
  39. Minniti CP, Kohn EC, Grubb JH, Sly WS, Oh Y, Muller HL, Rosenfeld RG, Helman LJ (1992) The insulin-like growth factor II (IGF-II)/mannose 6-phosphate receptor mediates IGF-II-induced motility in human rhabdomyosarcoma cells. J Biol Chem 267: 9000–9004PubMedGoogle Scholar
  40. Myers JL, Arocho J, Bernreuter W, Dunham W, Mazur MT (1991) Leiomyosarcoma of bone. A clinicopathologic, immunohistochemical, and ultrastructural study of five cases. Cancer 67: 1051–1056PubMedCrossRefGoogle Scholar
  41. Myhre-Jensen O, Kaae S, Hjollund Madsen E, Sneppen O (1983) Histopathological grading in soft-tissue tumours. Acta Pathol Microbiol Immunol Scand [A] 91: 145–150Google Scholar
  42. Neugut AI, Sordillo PP (1989) Leiomyosarcomas of the extremities. J Surg Oncol 40: 65–67PubMedCrossRefGoogle Scholar
  43. Nilbert M, Heim S, Mandhal N, Floderus UM, Willen H, Mitelman F (1988) Karyotypic rearrangements in 20 uterine leiomyomas. Cytogenet Cell Genet 49: 300–304PubMedCrossRefGoogle Scholar
  44. Nilbert M, Heims S, Mandhal N, Floderus UM, Willen H, Mitelman F (1990a) Trisomy 12 in uterine leiomyoma — a new cytogenetic subgroup. Cancer Genet Cytogenet 45: 63–66PubMedCrossRefGoogle Scholar
  45. Nilbert M, Mandhal N, Heim S, Rydholm A, Helm G, Willen H, Baldetorp B, Mitelman F (1990b) Complex karyotypic changes, including rearrangements of 12q13 and 14q24, in two leiomyosarcomas. Cancer Genet Cytogenet 48: 217–223PubMedCrossRefGoogle Scholar
  46. Nistal M, Paniagua R, Picazo ML et al. (1980) Granular changes of leiomyosarcoma. Virchow Arch [A] 386: 239–248CrossRefGoogle Scholar
  47. Ogawa K, Oguchi M, Yamabe H, Nakashima Y, Hamashima Y (1986) Distribution of collagen IV in soft tissue tumors. An immunohistochemical study. Cancer 58: 269–277PubMedCrossRefGoogle Scholar
  48. Oliver GF, Reiman HM, Gonchoroff NJ, Muller SA, Umbert IJ (1991) Cutaneous and subcutaneous leiomyosarcoma: a clinicopathologic review of 14 cases with reference to antidesmin staning and nuclear DNA patterns studied by flow cytometry. Br J Dermatol 124: 252–257PubMedCrossRefGoogle Scholar
  49. Polednak AP (1986) Incidence of soft-tissue cancers in blacks and whites in New York State. Int Cancer 38: 21–26CrossRefGoogle Scholar
  50. Ranchod M, Kempson RL (1977) Smooth muscle tumors of the gastrointestinal tract and retroperitoneum. A pathologic analysis of 100 cases. Cancer 39: 266–262Google Scholar
  51. Rangdaeng S, Truong LD (1991) Comparative immunohistochemical staining for desmin and muscle-specific actin. A study of 576 cases. Am J Clin Pathol 96: 32–45PubMedGoogle Scholar
  52. Ricci A, Ciccarelli O, Cartun RW, Newcomb P (1987) A clinicopathologic and immunohistochemical study of 16 patients with small intestinal leiomyosarcoma. Limited utility of immunophenotyping. Cancer 60: 1790–1799PubMedCrossRefGoogle Scholar
  53. Roholl PJ, Elbers HR, Prinsen I, Claessens JA, van Unnik J A (1990) Distribution of actin isoforms in sarcomas: an immunohistochemical study. Hum Pathol 21: 1269–1274PubMedCrossRefGoogle Scholar
  54. Roy M, Sommers SC (1989) Metastatic potential of gastric leiomyosarcoma. Pathol Res Pract 185: 874–877PubMedCrossRefGoogle Scholar
  55. Sait SN, dal Cin P, Sandberg AA (1988) Consistent chromosome changes in leiomyosarcoma. Cancer Genet Cytogenet 35: 47–50PubMedCrossRefGoogle Scholar
  56. Saul SH, Rast ML, Brooks JJ (1987) The immunohistochemistry of gastrointestinal stromal tumors. Evidence supporting an origin from smooth muscle. Am J Surg Pathol 11: 464–473PubMedCrossRefGoogle Scholar
  57. Schirmacher P, Held WA Yang D, Chisari FV, Rustum Y, Rogler CE (1992) Reactivation of insulin-like growth factor II during hepatocarcinogenesis in transgenic mice suggests a role in malignant growth. Cancer Res 52: 2549–2556PubMedGoogle Scholar
  58. Schurch W, Skalli O, Seemayer TA, Gabbiani G (1987) Intermediate filaments proteins and actin isoforms as markers for soft tissue tumor differentiation and origin. I. Smooth muscle tumors. Am J Pathol 128: 91–103PubMedGoogle Scholar
  59. Scott J, Cowell J, Robertson ME, Priestly LM et al. (1985) Insulin-like growth factor-II gene expression in Wilms’ tumour and embryonic tissues. Nature 317: 260–262PubMedCrossRefGoogle Scholar
  60. Smookler BM, Lauer DH (1983) Retroperitoneal leiomyosarcoma. A clinicopathologic analysis of 36 cases. Am J Surg Pathol 7: 269–280Google Scholar
  61. Stout AP, Hill WT (1958) Leiomyosarcoma of the superficial soft tissues. Cancer 11: 844–854PubMedCrossRefGoogle Scholar
  62. Stratton Mr, Williams S, Fisher C, Ball A, Westbury G, Gusterson BA et al. (1989) Structural alterations of the RBI gene in human soft tissue tumours. Br J Cancer 60: 201–205CrossRefGoogle Scholar
  63. Swanson PE, Wick MR, Dehner LP (1991) Leiomyosarcoma of somatic soft tissues in childhood: an immunohistochemical analysis of six cases with ultrastructural correlation. Hum Pathol 6: 569–577CrossRefGoogle Scholar
  64. Tirabosco R, Cavazzana AO, Santeusanio G, Spagnoli LG Gastrointestinal stromal tumor: evidence for a smooth muscle origin. Mod Pathol (submitted)Google Scholar
  65. Tollefsen SE, Sadow JL, Rotwein P (1989) Coordinate expression of insulin-like growth factor II and its receptor during muscle differentiation. Proc Natl Acad Sci USA 86: 1543–1547PubMedCrossRefGoogle Scholar
  66. Tricoli JV, Rail LB, Karakousis CP, Herrera L, Petrelli NJ, Bell GI, Shows TB (1986) Enhanced levels of insulin-like growth factor messenger RNA in human colon carcinomas and liposarcomas. Cancer Res 46: 6169–6173PubMedGoogle Scholar
  67. Trojani M, Contesso G, Coindre JM et al. (1984) Soft-tissue sarcomas of adults: study of pathological prognostic variables and definition of a histopathologic grading system. Int J Cancer 33: 37–42PubMedCrossRefGoogle Scholar
  68. Tsukada T, Mc Nutt MA, Ross R, Gown AM (1987) HHF-35, a muscle actin-specific mono-clonal antibody. II. Reactivity in normal, reactive, and neoplastiic human tissues. Am J Pathol 127: 389–403PubMedGoogle Scholar
  69. Tsushima K, Stanhope CR, Gaffey TA, Lieber MM (1988) Uterine leiomyosarcomas and benign smooth muscle tumors: usefulness of nuclear DNA patterns studied by flow cytometry. Mayo Clin Proc 61: 248–255Google Scholar
  70. Ueyama T, Guo KJ, Hashimoto H, Daimaru Y, Enjoji M (1992) A clinicopathologic and immunohistochemical study of gastrointestinal stromal tumors. Cancer 4: 947–955CrossRefGoogle Scholar
  71. Verela-Duran J, Oliva H, Rosai J (1979) Vascular leiomyosarcoma: the malignant counterpart of vascular leiomyoma. Cancer 44: 1684–1691CrossRefGoogle Scholar
  72. Vandekerckhove J, Weber K (1978) At least six different actins are expressed in a higher mammal: an analysis based on the amino acid sequence of the amino-terminal tryptic peptide. J Mol Biol 126: 783–802PubMedCrossRefGoogle Scholar
  73. Vandekerckhove J, Weber K (1981) Actin typing on total cellular extracts: a highly sensitive protein-chemical procedure able to distinguish different actins. Eur J Biochem 113: 595–603PubMedCrossRefGoogle Scholar
  74. Weiss RA, Mackay B (1981) Malignant smooth muscle tumors of the gastrointestinal tract: an ultrastructural study of 20 cases. Ultrastruct Pathol 12: 231–240CrossRefGoogle Scholar
  75. Wile AG, Evans HL, Romsdahl MM (1981) Leiomyosarcoma od soft tissue: a clinicopathologic study. Cancer 48: 1022–1032PubMedCrossRefGoogle Scholar
  76. Yannopoulos K, Stout AP (1962) Smooth muscle tumors in children. Cancer 15: 958PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • A. O. Cavazzana
  • V. Ninfo
  • R. Tirabosco
  • A. Montaldi
  • R. Frunzio

There are no affiliations available

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