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Malignant Fibrous Histiocytoma: A “Fibrohistiocytic” or Primitive, Fibroblastic Sarcoma

  • P. Meister
Chapter
Part of the Current Topics in Pathology book series (CT PATHOLOGY, volume 89)

Abstract

Synchronously with the acceptance of fibrohistiocytic tumors, especially of malignant fibrous histiocytoma (MFH) as a tumor type in the second edition of the WHO classification of soft tissue tumors (Weiss 1993), there is increasing criticism of MFH as an entity (Donhuijsen et al. 1987; Dehner 1988; Fletcher 1992). MFH of the bone was questioned as an entity already years ago (Dahlin et al. 1977). MFH as a sarcoma type became popular during 1960s among Stout and his co-workers (Ozello et al. 1963; O’Brien and Stout 1964; Stout and Lattes 1967). MFH was described as being characteristically composed of two cell types: (a) roundish or polygonal — histiocyte-like; and (b) spindly — fibroblast-like. Varying number of multinu-cleated giant cells, with or without atypia, may be admixed. Collagenous or mucoid intercellular substances vary intralesionally and interlesionally. A whorly cellular arrangement, called “storiform pattern,” was thought to be an important differential diagnostic criterion for MFH — even if not ubiquitous (Meister et al. 179; Enzinger 1986).

Keywords

Soft Tissue Tumor Malignant Peripheral Nerve Sheath Tumor Malignant Fibrous Histiocytoma Fibrous Histiocytoma Myxoid Liposarcoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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  • P. Meister

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