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Co-Cultures of Rat Hepatocytes in the Study of Valproate Toxicity

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Medical Toxicology

Part of the book series: Archives of Toxicology ((TOXICOLOGY,volume 15))

Abstract

The use of sodium valproate (VP), an effective anti-epileptic drug, has been associated with irreversible hepatotoxicity of which the mechanism has not yet been elucidated (Eadie 1988, Cotariu 1988).

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References

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Author information

Authors and Affiliations

  1. Department of Toxicology, Vrije Universiteit Brussel, Brussels, Belgium

    V. Rogiers, Y. Vandenberghe & A. Vercruysse

  2. Department of Biochemistry and Molecular Biology, University College London, London, UK

    M. Akrawi & E. Shephard

  3. Department of Biochemistry, Queen Mary and Westfield College, London, UK

    I. Phillips

Authors
  1. V. Rogiers
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  2. M. Akrawi
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  3. Y. Vandenberghe
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  4. E. Shephard
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  5. I. Phillips
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  6. A. Vercruysse
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Editor information

Editors and Affiliations

  1. Institit für Arbeitsphysiologie an der Universität Dortmund, Ardeystraße 67, D-W 4600, Dortmund 1, Germany

    H. M. Bolt

  2. Coronel Laboratory for Occupational and Environmental Health, Academic Medical Centre, University of Amsterdam, Meibergdreef 15, NL-1105 AZ, Amsterdam, The Netherlands

    F. A. de Wolff

  3. Dept. of Toxicology, University of Limburg, P.O.Box 616, NL 6200 MD, Maastricht, The Netherlands

    P. Th. Henderson

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© 1992 Springer-Verlag Berlin Heidelberg

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Rogiers, V., Akrawi, M., Vandenberghe, Y., Shephard, E., Phillips, I., Vercruysse, A. (1992). Co-Cultures of Rat Hepatocytes in the Study of Valproate Toxicity. In: Bolt, H.M., de Wolff, F.A., Henderson, P.T. (eds) Medical Toxicology. Archives of Toxicology, vol 15. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77260-3_21

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  • DOI: https://doi.org/10.1007/978-3-642-77260-3_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77262-7

  • Online ISBN: 978-3-642-77260-3

  • eBook Packages: Springer Book Archive

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