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The Role of Herpes Simplex Virus Glycoproteins in Immune Evasion

  • Chapter
Herpes Simplex Virus

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 179))

Abstract

Viruses have evolved mechanisms that favor their own survival by modifying the effectiveness of the host immune response. Although viral strategies for immune evasion are varied, many members of the herpesvirus family encode proteins that have immunoregulatory functions. Human cytomegalovirus (CMV) encodes a protein that shares homology with the heavy chain of the major histocompatibility complex class I molecule (Beck and Barrell 1988). This protein interacts with β 2-microglobulin and may interfere with cytotoxic T cell recognition of infected cells (Browne et al. 1990). BCRF1, a protein encoded by Epstein-Barr virus (EBV), is a homologue of interleukin-10 and inhibits synthesis of cytokines by activated T helper cells (Hsu et al. 1990).

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Author information

Authors and Affiliations

  1. Infectious Diseases Section, Department of Medicine, School of Medicine, University of Pennsylvania, USA

    G. Dubin, N. O. Fishman & H. M. Friedman

  2. Department of Microbiology, University of Pennsylvania, USA

    G. H. Cohen

  3. Center for Oral Health Research, School of Dental Medicine, University of Pennsylvania, USA

    R. J. Eisenberg & G. H. Cohen

  4. Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, USA

    R. J. Eisenberg

  5. Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, 19104, Philadelphia, Pennsylvania, USA

    H. M. Friedman

Authors
  1. G. Dubin
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  2. N. O. Fishman
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  3. R. J. Eisenberg
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  4. G. H. Cohen
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  5. H. M. Friedman
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Editor information

Editors and Affiliations

  1. Department of Microbiology, College of Veterinary Medicine, University of Tennessee, 37996-0845, Knoxville, TN, USA

    Barry T. Rouse BVSc, MSC, PhD

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© 1992 Springer-Verlag Berlin, Heidelberg

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Dubin, G., Fishman, N.O., Eisenberg, R.J., Cohen, G.H., Friedman, H.M. (1992). The Role of Herpes Simplex Virus Glycoproteins in Immune Evasion. In: Rouse, B.T. (eds) Herpes Simplex Virus. Current Topics in Microbiology and Immunology, vol 179. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77247-4_7

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  • DOI: https://doi.org/10.1007/978-3-642-77247-4_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77249-8

  • Online ISBN: 978-3-642-77247-4

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