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The Role of Herpes Simplex Virus Glycoproteins in Immune Evasion

  • G. Dubin
  • N. O. Fishman
  • R. J. Eisenberg
  • G. H. Cohen
  • H. M. Friedman
Chapter
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 179)

Abstract

Viruses have evolved mechanisms that favor their own survival by modifying the effectiveness of the host immune response. Although viral strategies for immune evasion are varied, many members of the herpesvirus family encode proteins that have immunoregulatory functions. Human cytomegalovirus (CMV) encodes a protein that shares homology with the heavy chain of the major histocompatibility complex class I molecule (Beck and Barrell 1988). This protein interacts with β 2-microglobulin and may interfere with cytotoxic T cell recognition of infected cells (Browne et al. 1990). BCRF1, a protein encoded by Epstein-Barr virus (EBV), is a homologue of interleukin-10 and inhibits synthesis of cytokines by activated T helper cells (Hsu et al. 1990).

Keywords

Herpes Simplex Virus Type Immune Evasion Alternative Complement Pathway Herpes Simplex Virus Glycoprotein Primary Herpes Simplex Virus Infection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin, Heidelberg 1992

Authors and Affiliations

  • G. Dubin
    • 1
  • N. O. Fishman
    • 1
  • R. J. Eisenberg
    • 3
    • 4
  • G. H. Cohen
    • 2
    • 3
  • H. M. Friedman
    • 1
    • 5
  1. 1.Infectious Diseases Section, Department of Medicine, School of MedicineUniversity of PennsylvaniaUSA
  2. 2.Department of MicrobiologyUniversity of PennsylvaniaUSA
  3. 3.Center for Oral Health Research, School of Dental MedicineUniversity of PennsylvaniaUSA
  4. 4.Department of Pathobiology, School of Veterinary MedicineUniversity of PennsylvaniaUSA
  5. 5.Department of Pathology and Laboratory MedicineChildren’s Hospital of PhiladelphiaPhiladelphiaUSA

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