Macrophages and Other Nonspecific Defenses: Role in Modulating Resistance Against Herpes Simplex Virus

  • L. Wu
  • P. S. Morahan
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 179)


Nonspecific host resistance is provided by effector cell systems, including the mononuclear phagocytes, i.e., circulating monocytes, and tissue macrophages (MOs), natural killer (NK) cells, and polymorphonuclear granulocytes (PMNs). These cells, together with cytokines, play various roles at different stages in the pathogenesis of HSV infection (Morahan et al. 1985; Mogensen 1979). Immunomodulation of nonspecific resistance is one useful approach to control HSV infection (Morahan and Murasko 1989). It has been effective in reducing mortality against HSV infections in immunosuppressed animals (Morahan and Pinto 1991) and may be especially useful in combination with chemotherapy (Connell et al. 1985).


Herpes Simplex Virus Intrinsic Resistance Immediate Early Adoptive Cell Transfer Antiviral Resistance 
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Copyright information

© Springer-Verlag Berlin, Heidelberg 1992

Authors and Affiliations

  • L. Wu
    • 1
  • P. S. Morahan
    • 1
  1. 1.Department of Microbiology and ImmunologyThe Medical College of PennsylvaniaPhiladelphiaUSA

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