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Herpes Simplex Virus pp 57–74Cite as

The Role of T Cell Immunity in Control of Herpes Simplex Virus

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 179))

Abstract

Since their characterization in the mid-1960s, thymus-derived, or T lymphocytes have been shown to participate in virtually every process of mammalian immunity. This participation can take the form of response modification, mediated by secreted physiologically active cytokines, or direct effector activity, as exemplified by cell-mediated cytolysis and the inhibition of viral replication by interferon-γ (IFN-γ).

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References

  • Allen EM, Weir JP, Martin S, Mercadal C, Rouse BT (1990) Role of coexpression of IL-2 and herpes simplex virus proteins in recombinant vaccinia virus vectors on levels of induced immunity. Viral Immunol 3: 207–215

    PubMed  CAS  Google Scholar 

  • Arvin AA, Sharp M, Smith S, Koropchak CM, Diaz PS, Kinchington P, Ruyechan W, Hay J (1991) Equivalent recognition of a varicella-zoster virus immediate early protein (IE62) and glycoprotein I by cytotoxic T lymphocytes of either CD4+ or CD84 phenotype. J Immunol 146: 257–264

    PubMed  CAS  Google Scholar 

  • Banks TA, Allen EM, Dasgupta S, Sandri-Goldin R, Rouse BT (1991) Herpes simplex virus type l-specific cytotoxic T lymphocytes recognize immediate early protein ICP27. J Virol 65: 3185–3191

    PubMed  CAS  Google Scholar 

  • Barnes PF, Mistry SD, Cooper CL, Pirmez C, Rea TH, Modlin RL (1989) Compartmentalization of a CD4+ T lymphocyte subpopulation in tuberculosis pleuritis. J Immunol 142:1114–1119

    PubMed  CAS  Google Scholar 

  • Berg EL, Goldstein LA, Jutila MA, Nakache M, Picker LJ, Streeter PR, Wu, NW, Zhou D, Butcher EC (1989) Homing receptors and vascular addressins: cell surface molecules that direct lymphocyte traffic. Immunol Rev 108: 5–18

    PubMed  CAS  Google Scholar 

  • Bernstein Dl, Stanberry LR, Kappes JC, Burke RL, Myer MG (1988) Antibody to herpes simplex virus (HSV) ICP-35 proteins after HSV challenge of animals immunized with HSV subunit vaccine. J Infect Dis 157: 1178–1186

    PubMed  CAS  Google Scholar 

  • Bertagnolli M, Herrmann S (1990) IL-7 supports the generation of cytotoxic T lymphocytes from thymocytes. Multiple lymphokines required for proliferation and cytotoxicity. J Immunol 145: 1706–1712

    PubMed  CAS  Google Scholar 

  • Biddison WE, Doherty PC, Webster RG (1977) Antibody to influenza virus. matrix protein detects a common antigen on the surface of cells infected with type A influenza viruses. J Exp Med 146: 690–697

    PubMed  CAS  Google Scholar 

  • Blacklaws BA, Nash AA (1990) Immunological memory to herpes simplex virus type 1 glycoproteins B and D in mice. J Gen Virol 71: 863–871

    PubMed  CAS  Google Scholar 

  • Blacklaws BA, Nash AA, Darby G (1987) Specificity of the immune response ot mice to herpes simplex virus glycoproteins B and D constitutively expressed on L cell lines. J Gen Virol 68: 1103–1114

    PubMed  CAS  Google Scholar 

  • Bodmer JM, Bastin JM, Askonas BA, Townsend ARM (1989) Influenza-specific cytotoxic T-cell recognition is inhibited by peptides unrelated in both sequence and MHC restriction. Immunology 66: 163–169

    PubMed  CAS  Google Scholar 

  • Bonneau RH, Jennings RH (1989) Modulation of acute and latent herpes simplex virus infection in C57BL/6 mice by adoptive transfer of immune lymphocytes with cytolytic activity. J Virol 63:1480–1484

    PubMed  CAS  Google Scholar 

  • Braakman E, Rotteveel FTM, van Bleek G, van Seventer GA, Lucas CJ (1987) Are MHC class ll-restricted cytotoxic T lymphocytes important? Immunol Today 8: 265–267

    Google Scholar 

  • Braciale TJ (1977) Immunologic recognition of influenza virus-infected cells. II. Expression of influenza A matrix protein on the infected cell surface and its role in recognition by cross-reactive cytotoxic T cells. J Exp Med 146: 673–690

    PubMed  CAS  Google Scholar 

  • Braciale TJ, Morrison LA, Sweetser MT, Sambrook J, Gething M-J, Braciale VL (1987) Antigen presentation pathways to class I and class II MHC-restricted T lymphocytes. Immunol Rev 98: 95–114

    PubMed  CAS  Google Scholar 

  • Corey L, Spear PG (1986) Infections with herpes simplex viruses. N Engl J Med 314: 686–691

    PubMed  CAS  Google Scholar 

  • Cresswell P (1987) Regulation of HLA class I and class II antigen expression. Br Med Bull 43: 66–80

    PubMed  CAS  Google Scholar 

  • Cunningham AL, Noble JR (1989) Role of keratinocytes in human recurrent herpetic lesions. Ability to present herpes simplex virus antigen and act as target for T lymphocyte cytotoxicity in vitro. J Clin Invest 83: 490–496

    PubMed  CAS  Google Scholar 

  • Cunningham AL, Turner RR, Miller AC, Para MF, Merigan TC (1985) Evolution of recurrent herpes simplex lesions: an immunolhistologic study. J Clin Invest 75: 226–233

    PubMed  CAS  Google Scholar 

  • Douglas RG, Couch RB (1970) A prospective study of chronic herpes virus infection and recurrent herpes labialis in humans. J Immunol 104: 289–295

    PubMed  CAS  Google Scholar 

  • Eberle R, Russell RG, Rouse BT (1981) Cell mediated immunity to herpes simplex virus: recognition of type specific and type common surface antigens by cytotoxic T cell populations. Infect Immun 34: 795–803

    PubMed  CAS  Google Scholar 

  • El-Asrar AM, Geboes K, Missotten L, Emarah MH, Desmet V (1990) Expression of MHC class II antigens and immunoglobulin M by the corneal epithelial cells in herpetic keratitis. Int Ophthalmol 14:233–239

    Google Scholar 

  • Farrar JJ, Simon PL, Farrar WL, Keopman J, Fuller-Bonar J (1981) Role of mitogenic factor, lymphocyte activating factor, and immune interferon in the induction of humoral and cell-mediated immunity. Ann NY Acad Sci 332: 303–315

    Google Scholar 

  • Farrar WL, Johnson HM, Farrar JJ (1982) Regulation of the production of immune interferon and cytotoxic T lymphocytes by interleukin 2. J Immunol 126: 1120–1125

    Google Scholar 

  • Fleischer B, Becht H, Rott R (1985) Recognition of viral antigens by human influenza A virus-specific T lymphocyte clones. J Immunol 135: 2800–2804

    PubMed  CAS  Google Scholar 

  • Fong TAT, Mosmann TR (1990) Alloreactive muring CD8+ T cell clones secrete the Th1 pattern of cytokines. J Immunol 144: 1744–1752

    PubMed  CAS  Google Scholar 

  • Glasgow LA (1974) Cytomegalovirus interference in vitro. Infect Immun 9: 702–707

    PubMed  CAS  Google Scholar 

  • Glorioso J, Kees U, Kumel G, Kirchner H, Krammer PH (1985) Identification of herpes simplex virus type 1 (HSV-1) glycoprotein gC as the immunodominant antigen for HSV-1-specific memory cytotoxic T lymphocytes. J Immunol 135: 575–582

    PubMed  CAS  Google Scholar 

  • Groenewegen G, Buurman WA, de Ley M, Kootstra G (1987) A new lymphokine different from interferon-γ induces major histocompatibility complex class II antigen expression. Transplant Proc 19: 190–191

    PubMed  CAS  Google Scholar 

  • Halloran PF, Wadgymar A, Autenreid P (1986) The regulation of expression of major histocompatibility complex products. Transplantation 41: 413–420

    PubMed  CAS  Google Scholar 

  • Hayward AR, Pontesilli O, Herberger M, Laszlo M, Levin M (1986) Specific lysis of varicella zoster virus-infected B lymphoblasts by human T cells. J Virol 58:179–184

    PubMed  CAS  Google Scholar 

  • Ho M (1977) Viral infections after transplantation in man. Arch Virol 55:1–24

    PubMed  CAS  Google Scholar 

  • Ho RJY, Burke RL, Merigan TC (1989) Antiven-presenting liposomes are effective in treatment of recurrent herpes simplex virus genitalis in guinea pigs. J Virol 63: 2951–2959

    PubMed  CAS  Google Scholar 

  • Horohov DW, Wyckoff JH, Moore RN, Rouse BT (1986) Regulation of herpes simplex virus-specific cell-mediated immunity by a specific suppressor factor. J Virol 58: 331–338

    PubMed  CAS  Google Scholar 

  • Jacobson S, Richert JR, Biddison WE, Satinsky A, Hartzmann RJ, McFarland HF (1984) Measles virus specific T4+ human cytotoxic T-cell clones are restricted by class II HLA antigens. J Immunol 133: 754–757

    PubMed  CAS  Google Scholar 

  • Jacobson S, Sekaly RP, Jacobson CL, McFarland HF, Long EO (1989) HLA class ll-restricted presentation of cytoplasmic measles virus antigens to cytotoxic T cells. J Virol 63:1756–1762

    PubMed  CAS  Google Scholar 

  • Johnson RM, Lancki DW, Fitch FW, Spear PG (1990) Herpes simplex virus glycoprotein D is recognized as antigen by CD4+ and CD8+ T lymphocytes from infected mice. Characterization of T cell clones. J Immunol 145: 702–710

    PubMed  CAS  Google Scholar 

  • Jonjic S, del Val M, Keil GM, Reddehase MJ, Koszinowski UH (1988) A nonstructural viral protein expressed by recombinant vaccinia virus protects against lethal cytomegalovirus infection. J Virol 62: 1653–1658

    PubMed  CAS  Google Scholar 

  • Kallenberg CGM, Schillizi BM, Beaumont F, Poppema S, De Leij L, The TH (1987) Expression of class II MHC antigens on alveolar epithelium in fibrosing alveolitis. Clin Exp Immunol 67:182–190

    PubMed  CAS  Google Scholar 

  • Kaplan DR, Griffith R, Braciale VL, Braciale TJ (1984) Influenza virus-specific human cytotoxic T cell clones: heterogeneity in antigenic specificity and restriction by class II MHC products. Cell Immunol 88:193–206

    PubMed  CAS  Google Scholar 

  • Kieff E, Hoyer B, Bachenheimer S, Roizman B (1972) Genetic relatedness of type 1 and type 2 herpes simplex viruses. J Virol 9: 738–745

    PubMed  CAS  Google Scholar 

  • Kohl S (1984) The immune response of the neonate to herpes simplex virus infection. In: Rouse BT, Lopez C (eds) Immunobiology of herpes simplex virus infection. CRC Press. Boca Raton

    Google Scholar 

  • Kolaitis G, Doymaz M, Rouse BT (1990) Demonstration of MHC class ll-restricted cytotoxic T lymphocyts in mice against herpes simplex virus. Immunology 71:101–106

    PubMed  CAS  Google Scholar 

  • Larsen HS, Rüssel RG, Rouse BT (1983) Recovery from lethal herpes simplex virus type 1 infection is mediated by cytotoxic T lymphocytes. Infect Immun 41:197–204

    PubMed  CAS  Google Scholar 

  • Larsen HS, Feng M-F, Horohov DW, Moore RN, Rouse BT (1984) Role of T-lymphocyte subsets in recovery from herpes simplex virus infection. J Virol 50: 56–59

    PubMed  CAS  Google Scholar 

  • rLathey JL, Martin S, Rouse BT (1987) Suppression of delayed type hypersensitivity to herpes simplex virus type 1 following immunization with an anti-idiotypic antibody: an example of split tolerance. J Gen Virol 68: 1093–1102

    Google Scholar 

  • Lawman MJP, Courtney RJ, Eberle R, Schaffer PA, O’hara MK, Rouse BT (1980a) Cell-mediated immunity to herpes simplex virus: specificity of cytotoxic T cells. Infect Immun 30: 451–461

    PubMed  CAS  Google Scholar 

  • Lawman MJP, Rouse BT, Courtney RJ, Walker RD (1980b) Cell-mediated immunity against herpes simplex induction of cytotoxic T lymphocytes. Infect Immun 27: 133–139

    PubMed  CAS  Google Scholar 

  • Leung KN, Nash AA, Sia DY, Wildy P (1984) Clonal analysis of T cell responses to herpes simplex virus: isolation, characterization and antiviral properties of an antigen-specific helper T-cell clone. Immunology 53: 623–633

    PubMed  CAS  Google Scholar 

  • Lindsley MD, Torpey DJ III, Rinaldo CR Jr (1986) HLA-DR-restricted cytotoxicity of cytomegalovirus infected monocytes mediated by leu-3-positive T cells. J Immunol 136: 3045–3051

    PubMed  CAS  Google Scholar 

  • Lopez C (1984) Natural resistance mechanisms against herpesvirus in health and disease. In: Immunobiology of herpes simplex virus infection. CRC Press, Boca Raton

    Google Scholar 

  • Martin S, Rouse BT (1987) The mechanism of antiviral immunity induced by a vaccinia recombinant expressing herpes simplex virus type 1 glycoprotein D. II. Clearance of local infection. J Immunol 138: 3431–3437

    PubMed  CAS  Google Scholar 

  • Martin S, Moss B, Berman PW, Laskey LA, Rouse BT (1987) Mechanisms of antiviral immunity induced by a vaccinia virus recombinant expressing herpes simplex virus type 1 glycoprotein D: cytotoxic T cells. J Virol 61: 726–734

    PubMed  CAS  Google Scholar 

  • Martin S, Xiuxuan Z, Silverstein SJ, Courtney RJ, Yao F, Jenkins FJ, Rouse BT (1990) Murine cytotoxic T lymphocytes specific for herpes simplex virus type 1 recognize the immediate early protein ICP4 but not ICPO. J Gen Virol 71: 2391–2399

    PubMed  CAS  Google Scholar 

  • McBride BW, Ridgeway P, Philipotts R, Newell DG (1989) Systemic and mucosal cell mediated immune responses against guinea-pigs detected by lymphocyte proliferation and monoclonal antibodies against macrophages and T cells. Vaccine 7: 409–416

    PubMed  CAS  Google Scholar 

  • Merigan TC, Stevens DA (1971) Viral infections in man associated with acquired immunological deficiency states. Fed Proc 30:1858–1864

    PubMed  CAS  Google Scholar 

  • Mester JC, Highlander SL, Osmand AP, Glorioso JC, Rouse BT (1990) Herpes simplex virus type 1-specific immunity induced by peptides corresponding to an antigenic site of glycoprotein B. J Virol 64: 5277–5283

    PubMed  CAS  Google Scholar 

  • Meuer SC, Acuto O, Hercend T, Schlossman SF, Reinherz EL (1984) The human T cell receptor. Ann Rev Immunol 2: 23–50

    CAS  Google Scholar 

  • Marahan PS (1984) Interactions of herpesviruses with mononuclear phagocytes. In: Immunobiology of herpes simplex virus infection. CRC Press, Boca Raton

    Google Scholar 

  • Nash AA, Ashford NPN (1982) Split T-cell tolerance in herpes simplex virus-infected mice and its implication for anti-viral immunity. Immunology 45: 761–767

    PubMed  CAS  Google Scholar 

  • Nash AA, Gell PGH (1983) Membrane phenotype of murine effector and suppressor T cells involved in delayed hypersensitivity and protective immunity to herpes simplex virus. Cell Immunol 75: 348–355

    PubMed  CAS  Google Scholar 

  • Nash AA, Jayasuriya A, Phelan J, Cobbold SP, Waldmann H, Prospero T (1987) Different roles for L3T4+ and Lyt2+ T cell subsets in the control of an acute herpes simplex virus infection of the skin and nervous system. J Gen Virol 68: 825–833

    PubMed  Google Scholar 

  • Ottenhoff THM, Mutis T (1990) Specific killing of cytotoxic T cells and antigen-presenting cells by CD4+ cytotoxic T cell clones. A novel potentially immunoregulatory T-T cell interaction in man. J Exp Med 171:2011–2024

    PubMed  CAS  Google Scholar 

  • Pass RF, Whitley RJ, Whelchel JD, Diethelm AG, Reynolds DW, Alford CA (1979) Identification of patients with increased risk of infection with herpes simplex virus after renal transplantation. J Infect Dis 140: 487–492

    PubMed  CAS  Google Scholar 

  • Pfizenmaier K, Starzinski-Powitz A, Rollinghoff M, Falke D, Wagner H (1977) T cell mediated cytotoxicity against herpes simplex virus-infected target cells. Nature 265: 630–632

    PubMed  CAS  Google Scholar 

  • Picker LJ, Terstappen LWMM, Rott LS, Streeter PR, Stein H, Butcher EC (1990) Differential expression of homing-associated adhesion molecules by T cell subsets in man. J Immunol 145: 3247–3255

    PubMed  CAS  Google Scholar 

  • Pitzalis C, Kingsley G, Haskard D, Panayi G (1988) The preferential accumulation of helper-inducer T lymphocytes in inflammatory lesions: evidence for regulation by selective endothelial and homotypic adhesion. Eur J Immunol 18:1397–1404

    PubMed  CAS  Google Scholar 

  • Prymowicz D, Moore RN, Rouse BT (1985) Frequency of herpes simplex virus-specific helper T lymphocyte precursors in the lymph node cells of infected mice. J Immunol 134: 2683–2688

    PubMed  CAS  Google Scholar 

  • Quinnan GV, Masur H, Rook AH, Armstrong G, Frederick WR, Epstein J, Manischewitz MS, Mecher AM, Jackson L, Ames J, Smith HA, Parker M, Pearson GR, Panillo J, Mitchell C, Strauss SE (1984) Herpesvirus infections in the acquired immune deficiency syndrome. JAMA 252: 72–77

    PubMed  Google Scholar 

  • Rand KH, Rasmussen LE, Pollard RB, Arvin AA, Merigan TC (1976) Cellular immunity and herpesvirus infections in cardiac transplant patients. N Engl J Med 296: 1372–1377

    Google Scholar 

  • Rasmussen LE, Jordan GW, Stevens DA, Merigan TC (1974) Lymphocyte interferon production and transformation after herpes simplex infections in humans. J Immunol 112: 728–736

    PubMed  CAS  Google Scholar 

  • Raulet D, Bevan MJ (1982) A differentiation factor required for the expression of cytotoxic T cell function. Nature 296: 754–757

    PubMed  CAS  Google Scholar 

  • Rosenthal KL, Smiley JR, South S, Johnson DC (1987) Cells expressing herpes simplex virus glycoprotein gC but not gB, gD, or gE are recognized by murine virus-specific cytotoxic T lymphocytes. J Virol 61: 2438–2447

    PubMed  CAS  Google Scholar 

  • Rouse BT (1984a) Cell-mediated immune mechanisms. In: Immunobiology of herpes simplex virus infection. CRC Press, Boca Raton

    Google Scholar 

  • Rouse BT (1984b) Role of adaptive immune defense mechanisms in herpes simplex resistance. In: Immunobiology of herpes simplex virus infection. CRC Press, Boca Raton

    Google Scholar 

  • Rouse BT, Lawman MJP (1980) Induction of cytotoxic T lymphocytes against herpes simplex virus type 1: role of accessory cells and amplifying factor. J Immunol 124: 2341–2346

    PubMed  CAS  Google Scholar 

  • Rouse BT, Wagner H (1984) Frequency of herpes simplex virus-specific cytotoxic T lymphocyte precursors in lymph node cells of infected mice. Immunology 51: 57–64

    PubMed  CAS  Google Scholar 

  • Rudd CE, Anderson P, Morimoto C, Streuli M, Schlossman SF (1989) Molecular interactions, T-cell subsets and a role of the CD4/CD8: p56, ck complex in human T-cell activation. Immunol Rev 111:226–265

    Google Scholar 

  • Ruddle NH, Homer R (1987) The role of lymphotoxin in inflammation. Prog Allergy 40:162–182

    Google Scholar 

  • Ruddle NH, McGrath K, James T, Schmid DS (1987) Purified lymphotoxin (LT) from class I restricted CTLs and class II restricted cytolytic helpers induce target cell DNA fragmentation. In: Bonavida B, Collier RJ (eds) Membrane-mediated cytotoxicity. Liss, New York

    Google Scholar 

  • Schmid DS (1988) The human MHC-restricted cellular response to herpes simplex virus type 1 is mediated by CD4+, CD8− T cells and is restricted to the DR region of the MHC complex. J Immunol 140:3610–3616

    PubMed  CAS  Google Scholar 

  • Schmid DS, Rouse BT (1983) Cellular interactions in the cytotoxic T lymphocyte response to herpes simplex virus antigens: differential antigen activation requirements for the helper T lymphocyte and cytotoxic T lymphocyte precursors. J Immunol 131: 479–484

    PubMed  CAS  Google Scholar 

  • Schmid DS, Larsen HS, Rouse BT (1981) The role of accessory cells and T cell-growth factor in induction of cytotoxic T lymphocytes against herpes simplex virus antigens. Immunology 44: 735–763

    Google Scholar 

  • Schmid DS, Larsen HS, Rouse BT (1982) Role of la antigen expression and secretory function of accessory cells in the induction of cytotoxic T lymphocyte responses against herpes simplex virus. Infect Immun 37:1138–1147

    PubMed  CAS  Google Scholar 

  • Schmid DS, Tite JP, Ruddle NH (1986) DNA fragmentation: manifestation of target cell destruction mediated by cytotoxic T-cell lines, lymphotoxin-secreting helper T cell clones, and cell-free lymphotoxin-containing supernatant. Proc Natl Acad Sci USA 83:1881–1885

    PubMed  CAS  Google Scholar 

  • Schrier RD, Pizer LI, Moorhead JW (1983) Type-specific delayed hypersensitivity and protective immunity induced by isolated herpes simplex glycoprotein. J Immunol 130:1413–1418

    PubMed  CAS  Google Scholar 

  • Sethi KK, Brandis H (1977) Specifically immune mouse T cells can destroy H-2 compatible murine target cells infected with herpes simplex virus types 1 and 2. Z Immunitatsforsch 150:162–173

    Google Scholar 

  • Sethi KK, Omata Y, Schneweis KE (1983) Protection of mice from fatal herpes simplex virus type 1 infection by adoptive transfer of cloned virus-specific and H-2 restricted cytolytic T lymphocytes. J Gen Virol 64: 443–447

    PubMed  Google Scholar 

  • Shore SL, Nahmias A (1981) Immunobiology of herpes simplex viruses. In: Nahmias AJ, O’Reill (eds) Immunology of human infections. Plenum, New York

    Google Scholar 

  • Siegal FP, Lopez C, Hammer GS, Brown AE, Kornfeld SJ, Gold J, Hassett J, Hirshman SZ, Cunningham-Rundles C, Adelsberg BR, Parham DM, Siegal M, Cunningham-Rundles S, Armstrong D (1981) Severe acquired immunodeficiency in male homosexuals manifested by chronic herpes simplex lesions. N Engl J Med 305:1439–1444

    PubMed  CAS  Google Scholar 

  • Sollid LM, Gaudernack G, Markussen G, Kvale D, Brantzaeg P, Thorsby E (1987) Induction of various HLA class II molecules in a human colonic adenocarcinoma cell line. Scand J Immunol 25:175–180

    PubMed  CAS  Google Scholar 

  • Spencer ES, Anderson HK (1970) Clinically evident nonterminal infections with herpes simplex viruses and the wart virus in immunosuppressed renal allograft patients. Br Med J iii: 251–254

    Google Scholar 

  • Stanberry LR, Kern ER, Richards JT, Overall JC Jr (1985) Recurrent genital herpes simplex virus infection in guinea pigs. Intervirology 24: 226–231

    PubMed  CAS  Google Scholar 

  • Stanberry LR, Bernstein Dl, Myers MG (1986) Evaluation of the herpes simplex virus antiviral activity of pyrethrins. Antiviral Res 6: 95–102

    PubMed  CAS  Google Scholar 

  • Stanberry LR, Burke RL, Myers MG (1988) Herpes simplex virus glycoprotein treatment of recurrent genital herpes. J Infect Dis 157: 156–163

    PubMed  CAS  Google Scholar 

  • Stanberry LR, Myers MG, Stephanopoulos DE, Burke RL (1989) Preinfection prophylaxis with herpes simplex virus glycoprotein immunogens: factors influencing efficacy. J Gen Virol 70: 3177–3185

    PubMed  CAS  Google Scholar 

  • Stanberry LR, Harrison CJ, Bravo FJ, Childs F, Reece AL, Bernstein Dl (1990) Recurrent genital herpes in the guinea pig augmented by ultraviolet radiation: effects of treatment with acyclovir. Antiviral Res 13: 227–236

    PubMed  CAS  Google Scholar 

  • Tan BTG, Ekelaar F, Lourink J, Rimmelzwaan G, DeJonge AJR, Scheper RJ (1986) Production of monoclonal antibodies defining guinea pig T cell surface markers and a strain 13 la-like antigen: the value of immunohistological screening. Hybridoma 4:115–124

    Google Scholar 

  • Taylor PM, Davey J, Howland K, Rothbard J, Askonas BA (1987) Class I MHC molecules, rather than other mouse genes dictate influenza epitope recognition by cytotoxic T cells. Immunogenetics 26: 267–271

    PubMed  CAS  Google Scholar 

  • Tite JP, Janeway CA Jr (1984) Cloned helper T cells can kill B lymphoma cells in the presence of specific antigen: la restriction and cognate vs. noncognate interactions in cytolysis. Eur J Immunol 14: 878–886

    PubMed  CAS  Google Scholar 

  • Torpey DJ III, Lindsley MD, Rinaldo CR Jr (1989) HLA-restricted lysis of herpes simplex virus-infected monocytes and macrophages mediated by CD4+ and CD8+ T lymphocytes. J Immunol 142: 1325–1332

    PubMed  Google Scholar 

  • Townsend ARM, Gotch FM, Davey J (1985) Cytotoxic T cells recognize fragments of nucleoprotein. Cell 42: 457–467

    PubMed  CAS  Google Scholar 

  • Townsend ARM, Rothbard J, Gotch FM, Bahadar G, Wraith D, McMichael AJ (1986) The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides. Cell 44: 959–968

    PubMed  CAS  Google Scholar 

  • van Binnendijk RS, Poelen MCM, De Vries P, Voorma HO, Osterhaus ADME, Uytdehaag KGCM (1989) Measles virus-specific human T cell clones. Characterization of specificity and function of CD4+ helper/cytotoxic and CD8+ cytotoxic T cell clones. J Immunol 142: 2847–2854

    PubMed  Google Scholar 

  • Wagner H, Hardt C, Rouse BT, Rollinghoff M, Scheurich P, Pfizenmaier K (1982) Dissection of the proliferative and differentiating signals controlling murine cytotoxic T lymphocyte response. J Exp Med 155: 1876–1881

    PubMed  CAS  Google Scholar 

  • Whitley RJ (1985) Epidemiology of herpes simplex viruses. In: Roizman B (ed) herpesviruses, vol 3. Plenum, New York

    Google Scholar 

  • Witmer LA, Rosenthal KL, Graham FL, Friedman HM, Yee A, Johnson DC (1990) Cytotoxic T lymphocytes specific for herpes simplex virus (HSV) studied using adenovirus vectors expressing HSV glycoproteins. J Gen Virol 71: 387–396

    PubMed  CAS  Google Scholar 

  • Yasukawa M, Zarling JM (1984a) Human cytotoxic T cell clones directed against herpes simplex virus-infected cells. I. Lysis restricted by HLA class II MB and DR antigens. J Immunol 133: 422–427

    PubMed  CAS  Google Scholar 

  • Yasukawa M, Zarling JM (1984b) Human cytotoxic T cell clones directed against herpes simplex virus-infected cells. II. Bifunctional clones with cytotoxic and virus-induced proliferative activities exhibit herpes simplex virus type 1 and type 2 specific or type common reactivities. J Immunol 133:2736–2742

    PubMed  CAS  Google Scholar 

  • Yasukawa M, Inatsuki A, Kobayashi Y (1989) Differential in vitro activation of CD4+ CD8− and CD8+ CD4+ herpes simplex virus-specific human cytotoxic T cells. J Immunol 143: 2051–2057

    PubMed  CAS  Google Scholar 

  • Zinkernagel R, Doherty PC (1979) MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness. Adv Immunol 27: 51–177

    PubMed  CAS  Google Scholar 

  • Zweerink HJ, Stanton LW (1981) Immune response to HSV infections: virus specific antibodies in sera from patients with recurrent facial infections. Infect Immun 31: 624–630

    PubMed  CAS  Google Scholar 

  • Zweerink HJ, Askonas BA, Millican D, Courtneidge SA, Skehel JJ (1977) Cytotoxic T cells to type A influenza virus: viral hemagglutinin induces A-strain specificity while infected cells confer cross-reactive cytotoxicity. Eur J Immunol 7: 630–635

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Viral Exanthems and Herpesvirus Branch, 1600 Clifton Rd., G18/7/206, 30333, Atlanta, GA, USA

    D. S. Schmid

  2. Department of Microbiology, College of Veterinary Medicine, University of Tennessee, 37996-0845, Knoxville, TN, USA

    B. T. Rouse

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  1. D. S. Schmid
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Editors and Affiliations

  1. Department of Microbiology, College of Veterinary Medicine, University of Tennessee, 37996-0845, Knoxville, TN, USA

    Barry T. Rouse BVSc, MSC, PhD

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Schmid, D.S., Rouse, B.T. (1992). The Role of T Cell Immunity in Control of Herpes Simplex Virus. In: Rouse, B.T. (eds) Herpes Simplex Virus. Current Topics in Microbiology and Immunology, vol 179. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77247-4_4

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