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Environmental Regulation of Shigella Virulence

  • Chapter
Pathogenesis of Shigellosis

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 180))

Abstract

Bacterial pathogens frequently find themselves exposed to a variety of diverse, frequently hostile conditions during their infectious cycle. The journey from the external environment to the host, where the bacteria may ultimately cause disease, is an adventurous one and involves exposure of the organism to a multitude of growth conditions. Successful pathogens have evolved the means for survival within the varied growth conditions encountered both inside and outside their respective hosts. The ability to synthesize proteins which facilitate survival under different growth conditions is part of an organism’s adaptive response. The adaptive response also involves mechanisms for sensing environmental changes and, in turn, regulating gene expression. Many examples exist of nonpathogenic bacteria which regulate genes in response to changes in their surroundings. Nutrient limitation, a shift in growth from one carbon source to another, a change from aerobic to anaerobic growth conditions, and changes in osmolarity and temperature are all signals to which bacteria respond by altering gene expression (reviewed by Gottesman 1984; Stock et al. 1989).

The opinion or assertions of A.T.M. and A.E.H. contained herein are the private ones of the authors and or not be construed as official or reflecting the views of te Department of Defense or the Uniformed Services University of Health Sciences

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Author notes

  1. A. E. Hromockyj

    Present address: Department of Microbiology and Immunology, Stanford University School of Medicine, 94305, Stanford, CA, USA

  2. M. L. Bernardini

    Present address: Dip. Di Biologia Cellulare e dello Sviluppo, Sezione Science Microbiologiche, Via degli Apuli, 1, 00195, Roma, Italia

Authors and Affiliations

  1. Department of Microbiology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, 20814-4799, Bethesda, MD, USA

    A. T. Maurelli & A. E. Hromockyj

  2. Unité de Pathogénie Microbienne Moléculaire, Institute Pasteur, 28 rue du Doctor Roux, 75724, Paris CEDEX 15, France

    M. L. Bernardini

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  1. A. T. Maurelli
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  2. A. E. Hromockyj
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  1. Unité de Pathogénie Microbienne Moleculaire, Institut Pasteur, 28, Rue du Dr. Roux, 75724, Paris Cedex 15, France

    P. J. Sansonetti M.D

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Maurelli, A.T., Hromockyj, A.E., Bernardini, M.L. (1992). Environmental Regulation of Shigella Virulence. In: Sansonetti, P.J. (eds) Pathogenesis of Shigellosis. Current Topics in Microbiology and Immunology, vol 180. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77238-2_5

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