Sensory transduction in eukaryotes

A comparison between Dictyostelium and vertebrate cells
  • Peter J. M. Van Haastert
  • Pim M. W. Janssens
  • Christophe Erneux
Part of the EJB Reviews 1991 book series (EJB REVIEWS, volume 1991)

Abstract

The organization of multicellular organisms depends on cell — cell communication. The signal molecules are often soluble components in the extracellular fluid, but also include odors and light. A large array of surface receptors is involved in the detection of these signals. Signals are then transduced across the plasma membrane so that enzymes at the inner face of the membrane are activated, producing second messengers, which by a complex network of interactions activate target proteins or genes [1].

Keywords

Tyrosine Adenosine Retina Serine Sponge 

Abbreviations

G-protein

GTP-binding regulatory protein

Gs

G-protein stimulating adenylate cyclase

Gi

G-protein inhibiting adenylate cyclase

InsP

InsP 2, InsP 3 (etc.) myo-inositol mono-, bis-, tris- (etc.) phosphates with isomeric numbering (all D-) as appropriate

PtdInsP2

phosphatidylinositol bisphosphate

GTP[γS]

5′-[γ-thio]tri-phosphate

GAP

GTPase-activating factor

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References

  1. 1.
    Alberts, B., Bray, D., Lewis, J., Raff, M., Roberts, K. & Watson, J. D. (1989) Molecular biology of the cell, pp. 682–726, Garland Publishing Inc., New York & London.Google Scholar
  2. 2.
    Casey, P. J. & Gilman, A. G. (1988) J. Biol. Chem. 263, 2577–2580.PubMedGoogle Scholar
  3. 3.
    Lefkowitz, R. J. & Caron, M. G. (1988) J. Biol. Chem. 263, 4993–4996.PubMedGoogle Scholar
  4. 4.
    Dohlman, H. G., Caron, M. G. & Lefkowitz, R. J. (1987) Biochemistry 26, 2657–2664.PubMedGoogle Scholar
  5. 5.
    Hunter, T. (1987) Cell 50, 823–829.PubMedGoogle Scholar
  6. 6.
    Williams, L. T. (1989) Science 243, 1564–1570.PubMedGoogle Scholar
  7. 7.
    Hunter, T. (1989) Cell 58, 1013–1016.PubMedGoogle Scholar
  8. 8.
    Nishibe, S, Wahl, M. L, Rhee, S. G. & Carpenter, G. (1989) J. Biol Chem. 264, 10335–10338.PubMedGoogle Scholar
  9. 9.
    Meisenhelder, J., Suh, P. G., Rhee, S. G. & Hunter, T. (1989) Cell 57, 1109–1122.PubMedGoogle Scholar
  10. 10.
    Margolis, B., Rhee, S. G., Felder, S. Mervic, M., Lyall, R., Levitzki, A., Ullrich, A., Zilberstein, A. & Schlessinger, J. (1989) Cell 57, 1101–1107.PubMedGoogle Scholar
  11. 11.
    Molloy, C. J., Bottaro, D. P., Fleming, T. P., Marshall, M. S., Gibbs, J. B. & Aaronson, S. A. (1989) Nature 342, 711–114.PubMedGoogle Scholar
  12. 12.
    Low, M. G. & Saltiel, A. R. (1988) Science 239, 268–275.PubMedGoogle Scholar
  13. 13.
    Czech, M. P., Klarlund, J. K., Yagaloff, K. A., Bradford, A. P. & Lewis, R. E. (1988) J. Biol. Chem 263, 11017–11020.PubMedGoogle Scholar
  14. 14.
    Gaulton, G. N., Kelly, K. L., Pawlowski, J., Mato, J. M. & Jarett, L. (1988) Cell 53, 963–970.PubMedGoogle Scholar
  15. 15.
    Villalba, M, Kelly, K. L. & Mato, J. M. (1988) Biochim. Biophys. Acta 968, 69–76.PubMedGoogle Scholar
  16. 16.
    Basler, K. & Hafen, E. (1988) Trends Genet. 4, 74–79.PubMedGoogle Scholar
  17. 17.
    Casanova, J. & Struhl, G. (1989) Genes Dev. 3, 2025–2038.PubMedGoogle Scholar
  18. 18.
    McKenzie, M. A., Fawell, S. E., Cha, M. & Lenard, J. (1988) Endocrinology 122, 511–517.PubMedGoogle Scholar
  19. 19.
    Dietz, E., Uhlenbruck, G. & Lutticken, R. (1989) Naturwissenschaften 76, 269–210.PubMedGoogle Scholar
  20. 20.
    Fawell, S. E. & Lenard, J. (1988) Biochem. Biophys. Res. Commun. 155, 59–65.PubMedGoogle Scholar
  21. 21.
    Garbers, D. L. (1989) J. Biol. Chem. 264, 9103–9106.PubMedGoogle Scholar
  22. 22.
    Thorpe, D. S. & Garbers, D. L. (1989) J. Biol. Chem. 264, 6545–6549.PubMedGoogle Scholar
  23. 23.
    Lowe, D. G., Chang, M. S., Hellmiss, R., Chen, E., Singh, S., Garbers, D. L. & Goeddel, D. V. (1989) EMBO J. 8, 1377–1384.PubMedGoogle Scholar
  24. 24.
    Chang, M. S., Lowe, D. G., Lewis, M., Hellmiss, R., Chen, E. & Goeddel, D. V. (1989) Nature 341, 68–72.PubMedGoogle Scholar
  25. 25.
    Chinkers, M., Garbers, D. L., Chang, M. S., Lowe, D. G., Chin, H., Goeddel, D. V. & Schulz, S. (1989) Nature 338, 78–83.PubMedGoogle Scholar
  26. 26.
    Chinkers, M. & Garbers, D. L. (1989) Science 245, 1392–1394.PubMedGoogle Scholar
  27. 27.
    Mato, J. M., Krens, F. A., Van Haastert, P. J. M. & Konijn, T. M. (1977) Proc. Natl Acad. Sci. USA 74, 2348–2351.PubMedGoogle Scholar
  28. 28.
    Wurster, B., Schubiger, K., Wick, U. & Gerisch, G. (1977) FEBS Lett. 76, 141–144.PubMedGoogle Scholar
  29. 29.
    Van Haastert, P. J. M. & Kien, E. (1983) J. Biol. Chem. 258, 9636–9642.PubMedGoogle Scholar
  30. 30.
    Klein, P. S., Sun, T. J., Saxe III, C. L., Kimmel, A. R., Johnson, R. L. & Devreotes, P. N. (1988) Science 241, 1467–1472.PubMedGoogle Scholar
  31. 31.
    Janssens, P. M. W., De Jong, C. C. C., Vink, A. A. & Van Haastert, P. J. M. (1989) J. Biol. Chem. 264, 4329–4335.PubMedGoogle Scholar
  32. 32.
    Koch, K. W. & Stryer, L. (1988) Nature 334, 64–66.PubMedGoogle Scholar
  33. 33.
    Klumpp, S. & Schultz, J. E. (1982) Eur. J. Biochem. 124, 317–324.PubMedGoogle Scholar
  34. 34.
    Schultz, J. E., Pohl, T. & Klumpp, S. (1986) Nature 322, 271–273.Google Scholar
  35. 35.
    Kung, C. & Saimi, Y. (1985) Curr. Top. Membr. Transp. 23, 45–66.Google Scholar
  36. 36.
    Saimi, Y., Hinrichsen, R. D., Forte, M. & Kung, C. (1983) Proc. Natl. Acad. Sci. USA 80, 5112–5116.PubMedGoogle Scholar
  37. 37.
    Stryer, L. & Bourne, H. R. (1986) Annu. Rev. Cell Biol. 2, 391–419.PubMedGoogle Scholar
  38. 38.
    Stryer, L. (1986) Annu. Rev. Neurosci. 9, 87–119.PubMedGoogle Scholar
  39. 39.
    Beato, M. (1989) Cell 56, 335–344.PubMedGoogle Scholar
  40. 40.
    Berg, J. M. (1989) Cell 57, 1065–1068.PubMedGoogle Scholar
  41. 41.
    Green, S. & Chambon, P. (1988) Trends Genet. 4, 309–313.PubMedGoogle Scholar
  42. 42.
    Ptashne, M. (1988) Nature 335, 683–689.PubMedGoogle Scholar
  43. 43.
    Levine, M. & Manley, J. L. (1989) Cell 59, 405–408.PubMedGoogle Scholar
  44. 44.
    Skowronski, R. & Feldman, D. (1989) Endocrinology 124, 1965–1972.PubMedGoogle Scholar
  45. 45.
    Loose, D. S., Schurman, D. & Feldman, D. (1981) Nature 293, 477–479PubMedGoogle Scholar
  46. 46.
    Feldman D., Do, Y., Burshell, A., Stathis P. & Loose D. S. (1982) Science 218, 297–298.PubMedGoogle Scholar
  47. 47.
    Loose, D. S., Stover, E. P., Restrepo, A., Stevens, D. A. & Feldman, D. (1983) Proc. Natl Acad. Sci. USA 80, 7659–7663.PubMedGoogle Scholar
  48. 48.
    Schar, G., Stover, E. P., Clemons, K. V. Feldman, D. & Stevens, D. A. (1986) Infect. Immunol. 52, 763.Google Scholar
  49. 49.
    Tanaka, S., Hasegawa, S., Hishinuma, F. & Kurata, S. (1989) Cell 57, 675–681.PubMedGoogle Scholar
  50. 50.
    De The, H., Del Mar Vivanco-Ruiz, M., Tiollais, P., Stunnenberg, H. & Dejean, A. (1990) Nature 343, 177–180.PubMedGoogle Scholar
  51. 51.
    Morris, H. R., Taylor, G. W., Masento, M. S., Jermyn, K. A. & Kay, R. R. (1987) Nature 328, 811–814.PubMedGoogle Scholar
  52. 52.
    Kay, R. R., Berks, M., Traynor, D., Taylor, G. W., Masento, M. S. & Morris, H. R. (1988) Dev. Genet 9, 579–587.PubMedGoogle Scholar
  53. 52a.
    Insall, R. Kay, R. R. (1990) EMBO J. 9, 3323–3328.PubMedGoogle Scholar
  54. 53.
    Newell, P. C. & Ross, F. M. (1982) J. Gen. Microbiol. 128, 2715–2724.Google Scholar
  55. 54.
    Theibert, A. & Devreotes, P. (1984) Dev. Biol. 106, 166–173.PubMedGoogle Scholar
  56. 55.
    Van Haastert, P. J. M. (1983) J. Biol. Chem. 258, 9643–9648.PubMedGoogle Scholar
  57. 56.
    Van Lookeren Campagne, M. M., Schaap, P. & Van Haastert, P. J. M. (1986) Dev. Biol. 117, 245–251.Google Scholar
  58. 57.
    Wolff, J. Londos, C. & Cooper, D. M. F. (1981) Biosci. Rep. 3, 309–322.Google Scholar
  59. 58.
    Wang, M., Van Haastert, P. J. M. & Schaap, P. (1986) Differentiation 33, 24–29.Google Scholar
  60. 59.
    Williams, G. B., Elders, E. M. & Sussman, M. (1984) Dev. Biol. 105, 377–388.PubMedGoogle Scholar
  61. 60.
    Dixon, R. A. F., Kobilka, B. K. Strader, D. J., Benovic, J. L., Dohlman, H. G., Frielle, T., Bolanowski, M. A., Bennett, C. D., Rands, E., Diehl, R. E., Mumford, R. A., Slater, E. E., Sigal, I. S., Caron, M. G., Lefkowitz, R. J. & Strader, C. D. (1986) Nature 321, 75–79.PubMedGoogle Scholar
  62. 61.
    Emorine, L. J., Marullo, S., Briend-Sutren, M. M., Patey, G., Tate, K., Delavier-Klutchko, C. & Strosberg, D. A. (1989) Science 245, 1118–1121.PubMedGoogle Scholar
  63. 62.
    Liao, C. F., Themmen, A. P. N., Joho, R., Barberis, C., Birnbaumer, M. & Birnbaumer, L. (1989) J. Biol. Chem. 264, 7328–7337.PubMedGoogle Scholar
  64. 63.
    Kubo, T., Fukuda, K., Mikami, A., Maeda, A., Takahashi, H., Mishina, M., Haga, T., Haga, K., Ichiyama, A., Kangawa, K. Kojima, M., Matsuo, H., Hirose, T. & Numa, S. (1986) Nature 323, 411–416.PubMedGoogle Scholar
  65. 64.
    Kubo, T., Maeda, A., Sugimoto, K., Akiba, L, Mikami, A., Takahashi, H., Haga, T., Haga, K., Ichiyama, A., Kangawa, K., Matsuo, H., Hirose, T. & Nama, S. (1986) FEBS Lett. 209, 361–312.Google Scholar
  66. 65.
    Peralta, E. G., Ashkenazi, A., Winslow, J. W., Smith, D. H., Ramachandran, J. & Capon, D. J. (1987) EMBO J. 6, 3923–3929.PubMedGoogle Scholar
  67. 66.
    Libert, F., Parmentier, M., Lefort, A., Dinsart, C., Van Sande, J., Maenhaut, C., Simons, M. J., Dumont, J. E. & Vassart, G. (1989) Science 244, 569–572.PubMedGoogle Scholar
  68. 67.
    Parmentier, M., Libert, F., Maenhaut, C., Lefort, A., Gérard, C., Perret, J., Van Sande, J. Dumont, J. E. & Vassart, G. (1989) Science 246, 1620–1622.PubMedGoogle Scholar
  69. 68.
    McFarland, K. C., Sprenghel, R., Philips, H. S., Köhler, M., Rosemblit, N., Nikolics, K., Segaloff, D. L. & Seeburg, PH. (1989) Science 245, 494–499.PubMedGoogle Scholar
  70. 69.
    Herskowitz, I. & Marsh, L. (1987) Cell 50, 995–996.PubMedGoogle Scholar
  71. 70.
    Treuheart, J., Boeke, J. D. & Fink, G. R. (1987) Mol. Cell. Biol. 7, 2316–2328.Google Scholar
  72. 71.
    Rose, M. D., Price, B. R. & Fink, G. R. (1986) Mol. Cell. Biol. 6, 3490–3497.PubMedGoogle Scholar
  73. 72.
    Burkholder, A. C. & Hartwell, L. H. (1985) Nucleic Acid Res. 73, 8463–8475.Google Scholar
  74. 73.
    Nakayama, N., Miyanjima, A. & Arai, K. (1985) EMBO J. 4, 2643–2648.PubMedGoogle Scholar
  75. 74.
    Bouvier, M., Collins, S., O’Dowd, B. F., Campbell, P. T., De Blasi, A., Kobilka, B. K., MacGregor, C., Irons, G. P. Caron, M. G. & Lefkowitz, R. J. (1989) J. Biol. Chem. 264, 16786–16792.PubMedGoogle Scholar
  76. 75.
    Sibley, D. R., Benovic, J. L., Caron, M. G. & Lefkowitz, R. J. (1987) Cell 48, 913–922.PubMedGoogle Scholar
  77. 76.
    Hausdorff, W. P., Bouvier, M., O’Dowd, B. F., Irons, G. P. Caron, M. G. & Lefkowitz, R. J. (1989) J. Biol. Chem. 264, 12657–12665.PubMedGoogle Scholar
  78. 77.
    Sibley, D. R., Daniel, K., Strader, C. D. & Lefkowitz, R. J. (1987) Arch. Biochem. Biophys. 258, 24–32.PubMedGoogle Scholar
  79. 78.
    Klein, C., Lubs-Haukeness, J. & Simons, S. (1985) J. Cell Biol. 100, 115–120.Google Scholar
  80. 79.
    Klein, P., Knox, B., Borleis, J. & Devreotes, P. N. (1985) J. Biol. Chem. 260, 1757–1764.PubMedGoogle Scholar
  81. 80.
    Vaughan, R. & Devreotes, P. N. (1988) J. Biol. Chem. 263, 14538–14543.PubMedGoogle Scholar
  82. 81.
    Reneke, J. E., Blumer, K. J., Courchesne, W. E. & Thorner, J. (1988) Cell 55, 221–234.PubMedGoogle Scholar
  83. 82.
    Konopka, J. B., Jenness, D. D. & Hartwell, L. H. (1988) Cell 54, 609–620.PubMedGoogle Scholar
  84. 83.
    Bouvier, M., Hausdorff, W. P., De Blasi, A., O’Dowd, B. F., Kobilka, B. K., Caron, M. G. & Lefkowitz, R. J. (1988) Nature 333, 310–313.Google Scholar
  85. 84.
    Van Haastert, P. J. M. (1987) J. Biol. Chem. 262, 7705–7710.PubMedGoogle Scholar
  86. 85.
    Bosch, L., Kraal, B. & Parmeggiani, A. (eds) (1989) The guanine nucleotide binding proteins, Plenum, New York, London.Google Scholar
  87. 86.
    Neer, E. J. & Clapham D. E. (1988) Nature 333, 129–134.PubMedGoogle Scholar
  88. 87.
    Freissmuth, M., Casey, P. J. & Gilman, A. G. (1989) FASEB J. 3, 2125–2131.PubMedGoogle Scholar
  89. 88.
    Lochrie, M. A. & Simon, M. I. (1988) Biochemistry 27, 4957–4965.PubMedGoogle Scholar
  90. 89.
    Birnbaumer, L. (1987) Trends Pharmacol. Sci. 8, 209–211.Google Scholar
  91. 90.
    Sullivan, K. A., Miller, R. T., Masters, S. B., Beiderman, B., Heideman, W. & Bourne, H. R. (1987) Nature 330, 758–760.PubMedGoogle Scholar
  92. 91.
    Masters, S. B., Stroud, R. M. & Bourne, H. R. (1986) Protein Engineering 1, 47–54.PubMedGoogle Scholar
  93. 92.
    Strathmann, M., Wilkie, T. M. & Simon, M. I., (1989) Proc. Natl Acad. Sci. USA 86, 7407–7409.PubMedGoogle Scholar
  94. 93.
    Pupillo, M., Kumagai, A., Pitt, G. S., Firtel, R. A. & Devreotes, P. N. (1989) Proc. Natl Acad. Sci. USA 86, 4892–4896.PubMedGoogle Scholar
  95. 94.
    Kumagai, A., Pupillo, M., Gundersen, R., Miake-Lye, R., Devreotes, P. N. & Firtel, R. A. (1989) Cell 57, 265–275.PubMedGoogle Scholar
  96. 95.
    Theibert, A. & Devreotes, P. (1986) J. Biol. Chem. 261, 15121–15125.PubMedGoogle Scholar
  97. 96.
    Van Haastert, P. J. M., Snaar-Jagalska, B. E. & Janssens, P. M. W. (1987) Eur. J. Biochem. 162, 251–258.PubMedGoogle Scholar
  98. 97.
    Van Haastert, P. J. M., De Vries, M. J., Penning, L. C., Roovers, E., Van der Kaay, J., Erneux, C. & Van Lookeren Campagne, M. M. (1989) Biochem. J. 258, 577–586.PubMedGoogle Scholar
  99. 98.
    Europe-Finner, G. N., Gammon, B., Wood, C. A. & Newell, P. C. (1989) J. Cell Sci. 93, 585–592.PubMedGoogle Scholar
  100. 99.
    Bominaar, A. A., Van der Kaay, J. & Van Haastert, P. J. M. (1991) Dev. Genet., in the press.Google Scholar
  101. 100.
    Coukell, M. B., Lappano, S. & Cameron, A. M. (1983) Dev. Genet. 3, 283–297.Google Scholar
  102. 101.
    Kesbeke, F., Snaar-Jagalska, B. E. & Van Haastert, P. J. M. (1988) J. Cell Biol. 107, 521–528.PubMedGoogle Scholar
  103. 102.
    Snaar-Jagalska, B. E., Kesbeke, F., Pupillo, M. & Van Haastert, P. J. M. (1988) Biochem. Biophys. Res. Commun. 156, 757–761.PubMedGoogle Scholar
  104. 103.
    Knecht, D. A. & Loomis, W. A. (1987) Science 236, 1081–1086.PubMedGoogle Scholar
  105. 104.
    De Lozanne, A. & Spudich, J. (1987) Science 236, 1086–1091.PubMedGoogle Scholar
  106. 105.
    Nakafuku, M., Obara, T., Kaibuchi, K., Miyajima, I., Miyajima, A., Itoh, H., Nakamura, S., Arai, K. I., Matsumoto, K. & Kaziro, Y. (1988) Proc. Natl Acad. Sci. USA 85, 1374–1378.PubMedGoogle Scholar
  107. 106.
    Nakafuku, M., Itoh, H., Nakamura, S. & Kaziro, Y. (1987) Proc. Natl Acad. Sci. USA 84, 2140–2144.PubMedGoogle Scholar
  108. 107.
    Dietzel, C. & Kurjan, J. (1987) Cell 50, 1001–1010.PubMedGoogle Scholar
  109. 108.
    Whiteway, M., Hougan, L., Dignard, D., Thomas, D. Y. Bell, L., Saari, G. C., Grant, F. J., O’Hara, P. & MacKay, V. L. (1989) Cell 56, 467–477.PubMedGoogle Scholar
  110. 109.
    Levitzki, A. (1988) Trends Biochem. Sci. 13, 298–301.PubMedGoogle Scholar
  111. 110.
    Nakayama, N., Kaziro, Y., Arai, K. & Matsumoto, K. (1988) Mol. Cell. Biol. 8, 3777–3783.PubMedGoogle Scholar
  112. 111.
    Jahng, K. Y., Ferguson, J. & Reed, S. I. (1988) Mol. Cell. Biol. 5, 2484–2493.Google Scholar
  113. 112.
    Cole, G. M., Stone, D. E. & Reed, S. I. (1990) Mol. Cell. Biol. 10, 510–511.PubMedGoogle Scholar
  114. 113.
    Rosenberg, G. B. & Pall, M. L. (1983) Arch. Biochem. Biophys. 221, 243–253.PubMedGoogle Scholar
  115. 114.
    Casperon G. F., Walker, N., Brasier, A. R. & Bourne, H. R. (1983) J. Biol. Chem. 258, 7911–7914.Google Scholar
  116. 115.
    Cohen R. J., Ness, J. L. & Whiddon, S. M. (1980) Phytochemistry 79, 1913–1918.Google Scholar
  117. 116.
    Hasunuma, K., Funadera, K., Tomita, K., Mukai, C. & Nakamura, T. (1987) Biochem. Biophys. Res. Comm. 143, 908–912.PubMedGoogle Scholar
  118. 117.
    Hasunuma, K., Furukawa, K., Tomita, K., Mukay, C. & Nakumura, T. (1987) Biochem. Biophys. Res. Commun. 148, 133–139.PubMedGoogle Scholar
  119. 118.
    Hasunuma, K., Furukawa, K., Funadera, K., Kubota, M. & Watanabe, M. (1987) Biochem. Photobiol. 46, 531–535.Google Scholar
  120. 119.
    Hasunuma, K., Miyamoto-Shinohara, Y. & Furukawa, K. (1987) Biochem. Biophys. Res. Commun. 146, 1178–1183.PubMedGoogle Scholar
  121. 120.
    Snaar-Jagalska, B. E., De Wit, R. J. W. & Van Haastert, P. J. M. (1988) FEBS. Lett. 232, 148–152.PubMedGoogle Scholar
  122. 121.
    Snaar-Jagalska, B. E., Jakobs, K. H. & Van Haastert, P. J. M. (1988) FEBS Lett. 236, 139–144.PubMedGoogle Scholar
  123. 122.
    Blumenfeld, A., Eruslimski, J., Heichat, O., Selinger, Z. & Minke, B. (1985) Proc. Natl Acad. Sci. USA 82, 7116–7120.PubMedGoogle Scholar
  124. 123.
    Brown, J. E., Watkins, D. C. & Malbon, C. C. (1987) Biochem. J. 247, 293–291.PubMedGoogle Scholar
  125. 124.
    Calhoon, R., Tsuda, M. & Ebrey, T. G. (1980) Biochem. Biophys. Res. Commun. 94, 1452–1457.PubMedGoogle Scholar
  126. 125.
    Paulsen, R. & Bentrop, J. (1986) Prog. Zool. 33, 299–319.Google Scholar
  127. 126.
    Paulsen, R., Bentrop, J., Hinsch, K. D. & Schulz, G. (1988) Mol. Physiol. Ret. Prot., 227–232.Google Scholar
  128. 127.
    Saibil, H. R. & Michel-Villaz, M. (1984) Proc. Natl Acad. Sci. USA 81, 5111–5115.PubMedGoogle Scholar
  129. 128.
    Stieve, H. & Lumme, G. (1989) FEBS Lett. 253, 6–10.PubMedGoogle Scholar
  130. 129.
    Tsuda, M., Tsuda, T. Teragama, Y., Fukada, Y., Akimo, T., Yamanaka, G., Stryer, L., Katada, T., Ui, M. & Ebrey, T. E. (1986) FEBS Lett. 198, 5–10.Google Scholar
  131. 130.
    Vandenberg, C. A. & Montai, M. (1984) Biochemistry 23, 2339–2347.PubMedGoogle Scholar
  132. 131.
    Burgoyne, R. F. (1989) Trends Biochem. Sci. 14, 394–396.PubMedGoogle Scholar
  133. 132.
    Santos, E. & Nebreda, A. R. (1989) FASEB J. 3, 2151–2163.PubMedGoogle Scholar
  134. 133.
    Bhullar, R. P., Chardin, P. & Haslam, R. J. (1990) FEBS Lett. 260, 48–52.PubMedGoogle Scholar
  135. 134.
    Zahraoui, A., Touchot, N., Chardin, P. & Tavitian, A. (1989) J. Biol. Chem. 264, 12394–12401.PubMedGoogle Scholar
  136. 135.
    Quinn, M. T., Parkos, C. A., Walker, L., Orkin, S. H., Dinauer, M. C. & Jesaitis, A. J. (1989) Nature 342, 198–200.PubMedGoogle Scholar
  137. 136.
    Haldar, S., Beatty, C., Tsujimoto, Y. & Croce, C. M. (1989) Nature 342, 195–198.PubMedGoogle Scholar
  138. 137.
    Didsbury, J., Weber, R. F., Bokoch, G. M., Evans, T. & Snyderman, R. (1989) J. Biol. Chem. 264, 16378–16382.PubMedGoogle Scholar
  139. 138.
    Lanoix, J., Roy, L. & Paiement, J. (1989) Biochem. J. 262, 497–503.PubMedGoogle Scholar
  140. 139.
    Klausner, R. D. (1989) Cell 57, 703–706.PubMedGoogle Scholar
  141. 140.
    Bacon, R. A., Salminen, A., Ruohola, H., Novick, P. & Ferro-Novick, S. (1989) J. Cell Biol. 109, 1015–1022.PubMedGoogle Scholar
  142. 141.
    Salminen, A. & Novick, P.J. (1989) J. Cell Biol. 109, 1023–1036.PubMedGoogle Scholar
  143. 142.
    Mayorga, L. S., Diaz, R. & Stahl, P. D. (1989) Science 244, 1475–1477.PubMedGoogle Scholar
  144. 143.
    Nakano, A. & Muramatsu, M. (1989) J. Cell Biol. 109, 2677–2691.PubMedGoogle Scholar
  145. 144.
    Walworth, N. C., Goud, B., Kastan Kabcenell, A. & Novick, P. J. (1989) EMBO J. 8, 1685–1693.PubMedGoogle Scholar
  146. 145.
    Zahraoui, A., Touchot, N. Chardin, P. & Tavitian, A. (1989) J. Biol. Chem. 264, 12394–12397.PubMedGoogle Scholar
  147. 146.
    Balch, W. E. (1989) J. Biol. Chem. 264, 16965–16968.PubMedGoogle Scholar
  148. 147.
    Goda, Y. & Pfeffer, S. R. (1989) FASEB J. 3, 2488–2495.PubMedGoogle Scholar
  149. 148.
    McCormick, F. (1989) Cell 56, 5–8.PubMedGoogle Scholar
  150. 149.
    Ballester, R., Michaeli, T., Ferguson, K., Xu, H. P., McCormick, F. & Wigler, M. (1989) Cell 59, 681–686.PubMedGoogle Scholar
  151. 150.
    Munder, T. & Küntzel, H. (1989) FEBS Lett. 242, 341–345.PubMedGoogle Scholar
  152. 151.
    Tanaka, K., Matsumoto, K. & Toh-E, A. (1989) Mol. Cell. Biol. 9, 757–768.PubMedGoogle Scholar
  153. 152.
    Broek, D., Toda, T., Michaeli, T., Levin, L., Birchmeier, C., Zoller, M., Powers, S. & Wigler, M. (1987) Cell 48, 789–799.PubMedGoogle Scholar
  154. 153.
    Camonis, J. H., Kalékine, M., Gondré, B., Garreau, H., Boy-Marcotte, E. & Jacquet, M. (1986) EMBO J. 5, 375–380.PubMedGoogle Scholar
  155. 154.
    Martegani, E., Baroni, M. D., Frascotti, G. & Alberghina, L. (1986) EMBO J. 5, 2363–2369.PubMedGoogle Scholar
  156. 155.
    Vogel, U. S., Dixon, R. A. F., Schaber, M. D., Diehl, R. E., Marshall, M. S., Scolnick, E. M., Sigal, I. S. & Gibbs, J. B. (1988) Nature 335, 90–93.PubMedGoogle Scholar
  157. 156.
    Kikuchi, A., Sasaki, T., Araki, S., Hata, Y. & Takai, Y. (1989) J. Biol. Chem. 264, 9133–9136.PubMedGoogle Scholar
  158. 157.
    Wolfman, A., Moscucci, A. & Macara, I. G. (1989) J. Biol. Chem. 264, 10820–10827.PubMedGoogle Scholar
  159. 158.
    West, M., Kung, H. & Kamata, T. (1990) FEBS Lett. 259, 245–248.PubMedGoogle Scholar
  160. 159.
    Kataoka, T., Broek, D. & Wigler, M. (1985) Cell 32, 493–505.Google Scholar
  161. 160.
    Casperson, G. P., Walker, N. & Bourne, H. (1985) Proc. Nati Acad. Sci. USA 82, 5060–5063.Google Scholar
  162. 161.
    Krupinski, J., Coussen, F., Bakalyar, H. A., Tang, W. J., Feinstein, P. G., Orth, K., Slaughter, C., Reed, R. R. & Gilman, A. G. (1989) Science 244, 1558–1564.PubMedGoogle Scholar
  163. 162.
    Young, D., Riggs, M., Field, J., Vojtek, A., Broek, D. & Wigler, M. (1989) Proc. Natl. Acad. Sci. USA 86, 7989–7993.PubMedGoogle Scholar
  164. 163.
    Lipkin, V. M., Khramtsov, N. V., Andreeva, S. G., Moshnyakov, M. V., Petukhova, G. V., Rakitina, T. V., Feshchenko, E. A., Ishchenko, K. A., Mirzoeva, S. F., Chernova, M. N. & Dranytsyna, S. M. (1989) FEBS Lett. 254, 69–73.PubMedGoogle Scholar
  165. 164.
    Gilman, A. G. (1984) Cell 36, 577–579.PubMedGoogle Scholar
  166. 165.
    Feder, D., Im, M. J., Klein, H. W., Hekman, M., Holzhöfer, A., Dees, C., Levitzki, A., Helmreich, E.J.M. & Pfeuffer, T. (1986) EMBO J. 5, 1509–1514.PubMedGoogle Scholar
  167. 166.
    Graziano, M. P. & Gilman, A. G. (1989) J. Biol. Chem. 264, 15475–15482.PubMedGoogle Scholar
  168. 167.
    Toda, T., Uno, L, Ishikawa, T., Powers, S., Kataoka, T., Broek, D., Cameron, S., Broach, J., Matsumoto, K. & Wigler, M. (1985) Cell 40, 21–36.Google Scholar
  169. 168.
    Marshall, M. S., Gibbs, J. B. Scolnick, E. M. & Sigal, I. S. (1988) Mol. Cell. Biol. 8, 52–61.PubMedGoogle Scholar
  170. 169.
    Toda, T., Camron, S., Sass, P., Zoller, M., Scott, J. D., McMullen, B., Hurwitz, M., Krebs, E. G. & Wigler, M. (1987) Mol. Cell. Biol. 7, 1311–1371.Google Scholar
  171. 170.
    Toda, T., Cameron, Sass, P. Zoller, M. & Wigler (1987) Cell 50, 277–287.PubMedGoogle Scholar
  172. 171.
    Matsumoto, K., Uno, I. & Ishikama, T. (1985) Yeast 1, 15–24.PubMedGoogle Scholar
  173. 172.
    Konijn, T. M., Van der Meene, J. G. C., Bonner, J. T. & Barkley, D. S. (1967) Proc. Natl Acad. Sci. USA 58, 1152–1154.PubMedGoogle Scholar
  174. 173.
    Shaffer, B. M. (1975) Nature 255, 549–552.PubMedGoogle Scholar
  175. 174.
    Gerisch, G. & Wick, U. (1975) Biochem. Biophys. Res. Commun. 65, 364–310.PubMedGoogle Scholar
  176. 175.
    Tomchik, K. J. & Devreotes, P. N. (1981) Science 212, 443–446.PubMedGoogle Scholar
  177. 176.
    Dinauer, M. C., MacKay, S. A. & Devreotes, P. N. (1980) J. Cell Biol. 86, 537–544.PubMedGoogle Scholar
  178. 177.
    Dinauer, M. C., Steck, T. L. & Devreotes, P. N. (1980) J. Cell. Biol. 86, 545–553.PubMedGoogle Scholar
  179. 178.
    Dinauer, M. C., Steck, T. L., & Devreotes, P. N. (1980) J. Cell. Biol. 86, 554–561.PubMedGoogle Scholar
  180. 179.
    Snaar-Jagalska, B. E. & Van Haastert, P. J. M. (1988) J. Cell Sci. 91, 287–294.PubMedGoogle Scholar
  181. 180.
    Leichtling, B. H., Majerfeld, I. H., Coffman, D. S., & Rickenberg, H. V. (1982) Biochem. Biophys. Res. Commun. 105, 949–955.PubMedGoogle Scholar
  182. 181.
    Arents, J. C. & Van Driel, R. (1982) FEBS Lett. 137, 201–204.Google Scholar
  183. 182.
    De Gunzburg, J. & Veron, M. (1982) EMBO J. 1, 1063–1068.PubMedGoogle Scholar
  184. 183.
    Kay, C. A., Noce, T. & Tsang, A. S. (1987) Proc. Natl Acad. Sci. USA 84, 2322–2326.PubMedGoogle Scholar
  185. 184.
    Tsang, A., Grant, C., Kay, C., Bain, G., Greenwood, M., Noce, T. & Tasaka, M. (1988) Dey. Genetics 8, 237–245.Google Scholar
  186. 185.
    Mutzel, R., Lacombe, M. L., Simon, M. N., De Gunzburg, J. & Veron, M. (1987) Proc. Natl Acad. Sci. USA 84, 6–10.PubMedGoogle Scholar
  187. 186.
    De Wit, R. J. W., Arents, J. C. & Van Driel, R. (1982) FEBS Lett. 145, 150–154.Google Scholar
  188. 187.
    Van Haastert, P. J. M. (1983) J. Biol. Chem. 258, 9643–9648.PubMedGoogle Scholar
  189. 188.
    Theibert, A., Palmisano, M., Jastorff, B. & Devreotes, P. (1986) Dev. Biol. 114, 529–533.PubMedGoogle Scholar
  190. 189.
    Schaap, P. & Van Driel, R. (1985) Exp. Cell Res. 159, 388–398.PubMedGoogle Scholar
  191. 190.
    Oyama, M. & Blumberg, D. D. (1986) Proc. Natl Acad. Sci. USA 83, 4819–4823.PubMedGoogle Scholar
  192. 191.
    Harirabu, B. & Dottin, R. P. (1986) Molec. Cell Biol. 6, 2402–2408.Google Scholar
  193. 192.
    Kimmel, A. R. (1987) Dev. Biol. 122, 163–171.PubMedGoogle Scholar
  194. 193.
    Van Ments-Cohen, M. & Van Haastert, P. J. M. (1989) J. Biol. Chem. 264, 8717–8722.PubMedGoogle Scholar
  195. 194.
    Schaap, P., Van Lookeren Campagne, M. M., Van Driel, R., Spek, W., Van Haastert, P. J. M. & Pinas, J. (1986) Dev. Biol. 118, 52–63.PubMedGoogle Scholar
  196. 195.
    Simon, M. N., Driscoll, D., Mutzel, R., Part, D., Williams, J. & Véron, M. (1989) EMBO J. 8, 2039–2043.PubMedGoogle Scholar
  197. 196.
    Ulloa, M., Mesrik E., Esteva, M., Torres, H. N. & Téllez-Inón, M. T. (1988) Biochem. J. 255, 319–326.PubMedGoogle Scholar
  198. 197.
    Paveto, C., Passeron, S. Corbin, J. D. & Moreno, S. (1989) Eur. J. Biochem. 179, 429–434.PubMedGoogle Scholar
  199. 198.
    Muller, G. & Bandlow, W. (1987) Yeast 3, 161–74.PubMedGoogle Scholar
  200. 199.
    Behrens, M. M. & Mazon, M. J. (1988) Biochem. Biophys. Res. Commun. 151, 561–567.PubMedGoogle Scholar
  201. 200.
    Nishizuku, Y. (1988) Nature 334, 661–665.Google Scholar
  202. 201.
    Berridge, M. J. & Irvine, R. F. (1989) Nature 341, 197–205.PubMedGoogle Scholar
  203. 202.
    Shears, S. B. (1989) Biochem. J. 260, 313–324.PubMedGoogle Scholar
  204. 203.
    Fain, J. N., Wallace, M. A. & Wojcikiewicz, R. J. H. (1988) FASEB J. 2, 2569–2574.PubMedGoogle Scholar
  205. 204.
    Ashenazik A., Peralta, E. G., Winslow, J. W. Ramachandran, J. & Capon, D. J. (1989) Cell 56, 487–493.Google Scholar
  206. 205.
    Baukal, A. J., Guillemette, G., Rubin, R. P., Spát, A. & Catt, K. J. (1985) Biochem. Biophys. Res. Commun. 133, 532–538.PubMedGoogle Scholar
  207. 206.
    Van Haastert, P. J. M. (1989) Anal. Biochem. 177, 115–119.PubMedGoogle Scholar
  208. 207.
    Pittet, D., Schleger, W., Lew, D. P., Monud, A. & Mayr, G. W. (1989) J. Biol. Chem. 264, 18489–18493.PubMedGoogle Scholar
  209. 208.
    Radenberg, T., Scholz, P. Bergmann, G. & Mayr, G. W. (1989) Biochem. J. 64, 323–333.Google Scholar
  210. 209.
    Volpe, P., Krause, K. H., Hashimoto, S., Zorzato, F., Pozzan, T., Meldolesi, J. & Lew, D. P. (1988) Proc. Natl Acad. Sci USA 85, 1091–1095.PubMedGoogle Scholar
  211. 210.
    Furulci, T., Yoshikawa, S, Milyawaki, A, Wada, K., Maeda, N. & Mikoshiba, K. (1989) Nature 342, 32–38.Google Scholar
  212. 211.
    Ferris, C. D., Huganir, R. L., Supattapone, S. & Snyder, S. H. (1989) Nature 342, 87–89.PubMedGoogle Scholar
  213. 212.
    Rossier, M. F., Capponi, A. M. & Vallotton, M. B. (1989) J. Biol. Chem. 264, 14078–14084.PubMedGoogle Scholar
  214. 213.
    Gill, D. L. (1989) Nature 342, 16–18.PubMedGoogle Scholar
  215. 214.
    Maeda, N., Niinobe, M. & Mikoshiba, K. (1990) EMBO J. 9, 61–67.PubMedGoogle Scholar
  216. 215.
    Penner, R., Neher, E., Takeshima, H., Nishimura, S. & Numa, S. (1989) FEBS Lett. 259, 217–221.PubMedGoogle Scholar
  217. 216.
    Woods, N. M. Cuthbertson, K. S. R. & Cobbold, P. H. (1986) Nature 319, 600–602.PubMedGoogle Scholar
  218. 217.
    Woods, N. M., Cuthbertson, K. S. R. & Cobbold, P. H. (1987) Cell Calcium 8, 79–100.PubMedGoogle Scholar
  219. 218.
    Jacob, R., Merritt, J. E., Hallam, T. J. & Rink, T. J. (1988) Nature 335, 40–45.PubMedGoogle Scholar
  220. 219.
    Berridge, M. J. & Galione, A. (1988) FASEB J. 2, 3074–3082.PubMedGoogle Scholar
  221. 220.
    Ambler, S. K., Poenie, M., Tsien, R. Y. & Taylor, P. (1988) J. Biol. Chem. 263, 1952–1959.PubMedGoogle Scholar
  222. 221.
    Jaconi, M. E. E., Rivest, R. W., Schlegel, W., Wollheim, C. B., Pittet, D. & Lew, P. D. (1988) J. Biol. Chem. 263, 10557–10560.PubMedGoogle Scholar
  223. 222.
    MacGlashan, D. (1989) J. Cell Biol. 109, 123–134.PubMedGoogle Scholar
  224. 223.
    Kawanishi, T., Blank, L. M., Harootunian, A. T., Smith, M. T. & Tsien, R. Y. (1989) J. Biol. Chem. 264, 12859–12866.PubMedGoogle Scholar
  225. 224.
    Rooney, T. A., Sass, E. J. & Thomas, A. P. (1989) J. Biol. Chem. 264, 11131–11141.Google Scholar
  226. 225.
    Hill, T. D., Dean, H. M. & Boynton, A. L. (1989) Science 242, 1176–1183.Google Scholar
  227. 226.
    Channgya, L., Gallacher, D. V., Irvine, R. F. & Petersen, O.H. (1989) FEBS Lett. 251, 43–48.Google Scholar
  228. 227.
    Snyder, P. M., Krause, K. H. & Welsh, M. J. (1988) J. Biol. Chem. 163, 11048–11051.Google Scholar
  229. 228.
    Irvine, R. F. & Moor, R. M. (1987) Biochem. Biophys. Res. Commun. 146, 284–290.PubMedGoogle Scholar
  230. 229.
    Irvine, R. F., Letcher, A. J., Heslop, J. P. & Berridge, M. J. (1986) Nature 320, 631–634.PubMedGoogle Scholar
  231. 230.
    Irvine, R. F. (1990) FEBS Lett. 263, 5–9.PubMedGoogle Scholar
  232. 231.
    Talwalker, R. T. & Lester, R. L. (1973) Biochim. Biophys. Acta 306, 412–421.Google Scholar
  233. 232.
    Kaibuchi, K., Miyazaki, A., Arai, K. & Matsumoto, K. (1986) Proc. Natl Acad. Sci. USA 843, 8172–8176.Google Scholar
  234. 233.
    Uno, L, Fukami, K., Kato, H., Takenawa, T. & Ishikawa, T. (1988) Nature 333, 188–190.PubMedGoogle Scholar
  235. 234.
    Kato, H., Ishikawa, T. & Takenawa, T. (1989) J. Biol. Chem. 264, 3116–3121.PubMedGoogle Scholar
  236. 235.
    Baer, K. M. & Saibil, H. R. (1988) J. Biol. Chem. 263, 17–20.PubMedGoogle Scholar
  237. 236.
    Wood, S. F., Szuts, E. Z. & Fein, A. (1989) J. Biol. Chem. 264, 12970–12976.PubMedGoogle Scholar
  238. 237.
    Rhee, S. G., Suh, P. G., Ryu, S. H. & Lee, S. Y. (1989) Science 244, 546–550.PubMedGoogle Scholar
  239. 238.
    Whitman, M., Downes, C. P., Keeler, M., Keller, T. & Cantley, L. (1988) Nature 332, 644–646.PubMedGoogle Scholar
  240. 239.
    Traynor-Kaplan, A., Harris, A. L., Thompson, B. L., Traylor, P. & Sclar, L.A. (1988) Nature 334, 353–356.PubMedGoogle Scholar
  241. 240.
    Traynor-Kaplan, A., Thompson, B. L., Harris, A. L., Traylor, P., Omann, G. M. & Sclar, L. A. (1989) J. Biol. Chem. 264, 15668–15673.PubMedGoogle Scholar
  242. 241.
    Stephens, L., Hawkins, P. T. & Downes, C. P. (1989) Biochem. J. 259, 261–216.Google Scholar
  243. 242.
    Auger, K. R., Carpenter, C. L., Cantley, L. C. & Varticovski, L. (1989) J. Biol Chem. 264, 20181–20184.PubMedGoogle Scholar
  244. 243.
    Auger, K. R., Serunian, L. A., Soltoff, P., Libby, P. & Cantley, L. C. (1989) Cell 57, 167–175.PubMedGoogle Scholar
  245. 244.
    Lips, D. L., Majerus, P. W., Gorga, F. R., Young, A. T. & Benjamin, T. L. (1989) J. Biol. Chem. 264, 8759–8763.PubMedGoogle Scholar
  246. 245.
    Serunian, L. A., Haber, M. T., Fukui, T., Kim, J. W. & Rhee, S. G. (1989) J. Biol Chem. 264, 17809–17815.PubMedGoogle Scholar
  247. 246.
    Burgoyne, R. D., Cheek, T. R. & O’Sullivan, A. J. (1987) Trends Biochem. Sci. 12, 332–333.Google Scholar
  248. 247.
    Pelech, S. L. & Vance, D. E. (1989) Trends Biochem. Sci. 14, 28–30.Google Scholar
  249. 248.
    Van Corven, E. J., Groenink, A., Jalink, K., Eichholtz, T. & Moolenaar, W. H. (1989) Cell 59, 45–54.PubMedGoogle Scholar
  250. 249.
    Irvine, R. F., Letcher, A. J., Brophy, P. J. & North, M. J. (1980) J. Gen. Microbiol 121, 495–497.Google Scholar
  251. 250.
    Varela, L, VanLookeren Campagne, M. M., Alvarez, J. F. & Mato, J. M. (1987) FEBS Lett. 211, 64–68.Google Scholar
  252. 251.
    MacDonald, J.I.S. & Weeks, G. (1985) Biochim. Biophys. Acta 834, 301–301.PubMedGoogle Scholar
  253. 252.
    Suchard, S. J., Rhoads, D. E. & Kaneshiro, E. S. (1989) J. Protozool 36, 185–190.PubMedGoogle Scholar
  254. 253.
    Majerus, P. W., Conolly, T. M., Bansal, V. S., Inhorn, R. C., Ross, T. S. & Lips, D. L. (1988) J. Biol. Chem. 263, 3051–3054.PubMedGoogle Scholar
  255. 254.
    Shears, S. B. (1989) Cellular Signalling 1, 125–133.PubMedGoogle Scholar
  256. 255.
    Downes, C. P., Mussat, M. C. & Michell, R. H. (1982) Biochem. J. 203, 169–111.PubMedGoogle Scholar
  257. 256.
    Hansen, C. A., Johanson, R. A., Williamson, M. T. & Williamson, J. K. (1987) J. Biol Chem. 262, 17319–17326.PubMedGoogle Scholar
  258. 257.
    Erneux, C., Lemos, M., Verjans, B., Vanderhaeghen, P., Delvaux, A. & Dumont, J. E. (1989) Eur. J. Biochem. 181, 281–288.Google Scholar
  259. 258.
    Hansen, C. A., Mah, S. & Williamson, J. K. (1986) J. Biol. Chem. 261, 8100–8103.PubMedGoogle Scholar
  260. 259.
    Hawkins, P. T., Stephens, L. & Downes, C. P. (1986) Biochem. J. 238, 501–516.PubMedGoogle Scholar
  261. 260.
    Ry, S. H., Lee, S. Y., Lee, K. Y. & Rhee, S. G. (1987) FASEB J. 1, 388–393.Google Scholar
  262. 261.
    Takazawa, K., Passareiro, H., Dumont, J. E. & Erneux, C. (1989) Biochem. J. 261, 483–488.PubMedGoogle Scholar
  263. 262.
    Biden, T. J., Altin, J. G., Karjalainen, A. & Bygrave, F. L. (1988) Biochem. J. 256, 697–701.PubMedGoogle Scholar
  264. 263.
    King, W. C. & Rittenhouse, S. E. (1989) J. Biol. Chem. 264, 6070–6074.PubMedGoogle Scholar
  265. 264.
    Inhorn, B. C., Bansal, V. S. & Majerus, P. W. (1987) Proc. Nati Acad. Sci. USA 74, 2170–2174.Google Scholar
  266. 265.
    Delvaux, A., Erneux, C., Moreau, C. & Dumont, J. E. (1987) Biochem. J. 242, 193–198.PubMedGoogle Scholar
  267. 266.
    Delvaux, A., Dumont, J. E. & Erneux, C. (1989) Second messengers andphosphoproteins vol. 12, pp. 281–288, Raven Press, New York.Google Scholar
  268. 267.
    Delvaux, A., Dumont, J. E. & Erneux, C. (1987) Biochem. Biophys. Res. Commun. 145, 59–65.PubMedGoogle Scholar
  269. 268.
    Gee, N. S., Ragan, C. L, Watling, K. J., Aspley, S., Jackson, R. G., Reid, G. G., Gani, D. & Shute, J. K. (1987) Biochem J. 247,883–889.Google Scholar
  270. 269.
    Van Lookeren Campagne, M. M., Erneux, C., Van Eijk, R. & Van Haastert, P. J. M. (1988) Biochem. J. 254, 343–350.Google Scholar
  271. 270.
    Joseph, S. K., Esch, T. & Bonner, W. D. (1989) Biochem J. 264, 851–856.PubMedGoogle Scholar
  272. 271.
    Ettlinger, C. & Lehle, L. (1988) Nature 331, 176–178.PubMedGoogle Scholar
  273. 272.
    Berridge, M. J., Downes, C. P. & Hanley, M. R. (1989) Cell 59, 411–419.PubMedGoogle Scholar
  274. 273.
    Avissar, S, Schreiber, G., Danon, A. & Belmaker, R. H. (1988) Nature 331, 440–442.PubMedGoogle Scholar
  275. 274.
    Van Lookeren Campagne, M. M., Wang, M., Spek, W., Peters, D. & Schaap, P. (1988) Dev. Genetics 9, 589–596.Google Scholar
  276. 275.
    Peters, D. J. M., Van Lookeren-Campagne, M. M., Van Haastert, P. J. M., Spek, W. & Schaap (1989) J. Cell Sci. 93, 205–210.PubMedGoogle Scholar
  277. 276.
    Luderus, M. E. E., Van der Most, R. G., Otte, A. P. & Van Driel, R. (1989) FEBS Lett. 253, 71–75.Google Scholar
  278. 277.
    Van Haastert, P. J. M., De Wit, R. J. W. & Van Lookeren Campagne, M. M. (1985) Biochem. Biophys. Res. Commun. 128, 185–192.PubMedGoogle Scholar
  279. 278.
    Luderus, M. E. E., Reymond, C. D., Van Haastert, P. J. M. & Van Driel, R. (1988) J. Cell Sci. 90, 701–706.PubMedGoogle Scholar
  280. 279.
    Ginsburg, G. & Kimmel, A. R. (1989) Proc. Natl Acad. Sci. USA 86, 9332–9336.PubMedGoogle Scholar
  281. 280.
    Gramzow, M., Zimmermann, H., Janetzko, A., Dorn, A., Kurelec, B., Schroder, H. C. & Müller, W. E. (1988) Exp. Cell Res. 179, 243–252.PubMedGoogle Scholar
  282. 281.
    Toda, T., Uno, L, Ishikawa, T., Powers, S., Kataoka, T., Broek, D., Cameron, S., Broach, J., Matsumoto, K. & Wigler, M. (1985) Cell 40, 27–36.PubMedGoogle Scholar
  283. 282.
    Beckner, S. K., Hattori, S. & Shih, T. Y. (1985) Nature 317, 71–72.PubMedGoogle Scholar
  284. 283.
    Birchmeier, C., Broek, D. & Wigler, M. (1985) Cell 43, 615–621.PubMedGoogle Scholar
  285. 284.
    Wakelam, M. J. O., Davies, S. A., Houslay, M. D., McKay, L, Marshall, C. J. & Hall, A. (1986) Nature 323, 173–176.PubMedGoogle Scholar
  286. 285.
    Alonso, T., Morgan, R. O., Marvizon, J. C., Zarlb, H. & Santos, E. (1988) Proc. Natl Acad. Sci. USA 85, 4271–4275.PubMedGoogle Scholar
  287. 268.
    Wakelam, M. J. O. (1988) FEBS Lett. 228, 182–186.PubMedGoogle Scholar
  288. 287.
    Huang, M., Chida, K., Kamata, N., Nose, K., Kato, M., Homma, Y., Takenawa, T. & Kuroki, T. (1988) J. Biol. Chem. 263, 11915–11980.Google Scholar
  289. 288.
    Downward, J., De Gunzburg, J., Riehl, R. & Weinberg, R. A. (1988) Proc. Natl Acad. Sci USA 85, 5774–5778.PubMedGoogle Scholar
  290. 289.
    Price, B. D., Morris, J. D. H., Marshall, C. J. & Hall, A. (1989) J. Biol. Chem. 264, 16638–16643.PubMedGoogle Scholar
  291. 290.
    Chiarugi, V. P., Magnelli, L., Pasquali, F., Basi, G. & Ruggiero, M. (1989) FEBS Lett. 252, 129–134.PubMedGoogle Scholar
  292. 291.
    Yu, C. L., Tsai, M. H. & Stacey, D. W. (1988) Cell 52, 63–71.PubMedGoogle Scholar
  293. 292.
    Lloyd, A. C., Paterson, H. F., Morris, J. D. H., Hall, A. & Marshall, C. J. (1989) EMBO J. 8, 1099–1104.PubMedGoogle Scholar
  294. 293.
    Robbins, S. M., Williams, J. G., Jermyn, K. A., Spiegelman, G. B. & Weeks, G. (1989) Proc. Natl Acad. Sci. USA 86, 938–942.PubMedGoogle Scholar
  295. 294.
    Reymond, C. D., Gomer, R. H., Mehdy, M. C. & Firtel, R. A. (1984) Cell 39, 141–148.PubMedGoogle Scholar
  296. 295.
    Reymond, C. D., Gomer, R. H., Nelien, W., Theibert, A., Devreotes, P. & Firtel, R. (1986) Nature 323, 340–343.PubMedGoogle Scholar
  297. 296.
    Van Haastert, P. J. M., Kesbeke, F., Reymond, C. D., Firtel, R., Luderus, E. & Van Driel, R. (1987) Proc. Natl Acad. Sci USA 84, 4905–4909.PubMedGoogle Scholar
  298. 297.
    Europe-Finner, G. N., Luderus, M. E. E., Small, N. V., Van Driel, R., Reymond, C. D., Firtel, R. A. & Newel, P. C. (1988) J. Cell Sci. 89, 13–20.PubMedGoogle Scholar
  299. 298.
    Klein, G., Martin, J. B., Satre, M. & Reymond, C. (1989) Experientia 4, 365–367.Google Scholar
  300. 299.
    Sato, M. (1989) Jap. J. Physiol 39, 461–474.Google Scholar
  301. 300.
    Hockberger, P. E. & Swandulla, D. (1987) Cell Mol. Neurobiol 7, 229–236.PubMedGoogle Scholar
  302. 301.
    Adams, J., Barakeh, J., Laskey, R. & Van Breemen, C. (1989) FASEB J. 3, 2389–2400.PubMedGoogle Scholar
  303. 302.
    Rosenthal, W., Hescheler, J., Trautwein, W. & Schultz, G. (1988) FASEB J. 2, 2784–2790.PubMedGoogle Scholar
  304. 303.
    Müller, U., Malchow, D. & Härtung, K. (1986) Biochim. Biophys. Acta 857, 281–290.Google Scholar
  305. 304.
    Malchow, D., Nanjundiah, V. & Gerisch, G. (1978) J. Cell Sci 50, 319–330.Google Scholar
  306. 305.
    Bumann, J., Wurster, B. & Malchow, D. (1983) J. Cell Biol 98, 173–178.Google Scholar
  307. 306.
    Aeckerle, S., Wurster, B. & Melchow, D. (1985) EMBO J. 4, 39–43.PubMedGoogle Scholar
  308. 307.
    Bumann, J., Malchow, D. & Wurster, B. (1986) Differentiation 31, 85–91.PubMedGoogle Scholar
  309. 308.
    Aeckerle, S. & Malchow, D. (1989) Biochim. Biophys. Acta 1012, 196–200.PubMedGoogle Scholar
  310. 309.
    Van Duijn, B. & Vogelzang, S. A. (1989) Biochim. Biophys. Acta 983, 186–192.PubMedGoogle Scholar
  311. 310.
    Wick, U., Malchow, D. & Gerisch, G. (1978) Cell Biol. Intern. Rep. 2, 11–19.Google Scholar
  312. 311.
    Europe-Finner, G. N. & Newell, P. C. (1985) FEBS Lett. 186, 70–73.PubMedGoogle Scholar
  313. 312.
    Boehme, R., Bumann, J., Aeckerle, S. & Malchow, D. (1987) Biochim. Biophys. Acta 904, 125–130.Google Scholar
  314. 313.
    Milne, J. L. & Coukell, M. B. (1988) Biochem. J 249, 223–230.PubMedGoogle Scholar
  315. 314.
    Milne, J. L. & Coukell, M. B. (1989) Exp. Cell Res. 185, 21–32.PubMedGoogle Scholar
  316. 315.
    Mato, J. M., Krens, F. A., Van Haastert, P. J. M. & Konijn, T.M. (1977) Proc. Natl Acad. Sci. USA 74, 2348–2351.PubMedGoogle Scholar
  317. 316.
    Saito, M. (1976) Exp. Cell Res. 123, 79–86.Google Scholar
  318. 317.
    Van Duijn, B., Vogelzang, S. A., Ypey, D. L., Van der Molen, L. G. & Van Haastert, P. J. M. (1990) J. Cell Sci. 95, 177–183.PubMedGoogle Scholar
  319. 318.
    Kung, C. & Saimi, Y. (1985) Curr. Top. Membr. Transp. 23, 45–66.Google Scholar
  320. 319.
    Vicentini, L. M., Cervini, R., Zippel, R. & Mantegazza, P. (1988) FEBS Lett. 228, 246–250.Google Scholar
  321. 320.
    Otte, A. P., Van Run, P., Heideveld, M., Van Driel, R. & Durston, A. J. (1989) Cell 58, 641–648.PubMedGoogle Scholar
  322. 321.
    Mann, S. K. & Firtel, R. A. (1989) Proc. Natl Acad. Sci. USA 86, 1924–1928.PubMedGoogle Scholar
  323. 322.
    Barra, J., Barrand, P., Blondelet, M. H. & Brächet, P. (1980) Mol. Gen. Genet. 177, 607–613.PubMedGoogle Scholar
  324. 323.
    Barcley, S. L. & Henderson, E. J. (1986) Differentiation 33, 111–120.Google Scholar
  325. 324.
    Kesbeke, F. & Van Haastert, P. J. M. (1988) Dev. Biol. 130, 464–470.PubMedGoogle Scholar
  326. 325.
    Schaap, P., Van Lookeren Campagne, M. M., Van Driel, R., Spek, W., Van Haastert, P. J. M. & Pinas, J. (1986) Dev. Biol. 118, 52–63.PubMedGoogle Scholar
  327. 326.
    Ross, F. M. & Newell, P. C. (1981) J. Gen. Microbiol. 127, 339–350.PubMedGoogle Scholar
  328. 327.
    Coukell, M. B. & Cameron, A. M. (1985) J. Bacteriol. 162, 427–429.PubMedGoogle Scholar
  329. 328.
    Van Haastert, P. J. M., Van Lookeren Campagne, M. M. & Ross, F. M. (1982) FEBS Lett. 147, 149–152.PubMedGoogle Scholar
  330. 329.
    Janssens, P. M. W. (1987) Trends Biochem. Sci. 12, 456–459.Google Scholar
  331. 330.
    Janssens, P. M. W. (1988) Comp. Biochem. Physiol. 90A, 209–223.Google Scholar
  332. 331.
    Janssens, P. M. W. & Van Haastert, P. J. M. (1987) Microbiol. Rev. 51, 396–418.PubMedGoogle Scholar
  333. 332.
    Gerisch, G. (1987) Annu. Rev. Biochem. 56, 853–879.PubMedGoogle Scholar
  334. 333.
    Firtel, R. A., Van Haastert, P. J. M., Kimmel, A. R. & Devreotes, P. N. (1989) Cell 58, 235–239.PubMedGoogle Scholar
  335. 334.
    Devreotes, P. (1989) Science 5, 242–245.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • Peter J. M. Van Haastert
    • 1
  • Pim M. W. Janssens
    • 2
  • Christophe Erneux
    • 3
  1. 1.Department of BiochemistryUniversity of GroningenGroningenThe Netherlands
  2. 2.Central Clinical Chemical LaboratorySt. Radboud University HospitalNijmegenThe Netherlands
  3. 3.Institute of Interdiciplinary Research, School of MedicineFree University of BrusselsBelgium

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