Summary
The effect of ischemia on energy-related metabolites and monoamines was investigated in the cerebral cortex and striatum of adult and young gerbils. Brain ischemia was induced by bilateral carotid artery occlusion for 5 or 15 min alone or with 1 h of recirculation. Both periods of ischemia with and without reflow similarly affected the energy-related metabolites in the cortex and striatum of adult and young animals. The ischemic monoamine changes showed regional differences dependent on the age of the animals and on the individual neurotransmitter system. The delayed alteration of monoamines in the cortex and striatum of the young animals observed in reflow but not during ischemia as seen in adults resembles the described “maturation” phenomenon in the adult brain.
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Spatz, M., Kumami, K., Ueki, Y., Djuricic, B.D., Mrsulja, B.B. (1992). Cerebral Ischemia in Adult and Young Mongolian Gerbils: Delayed Changes in Monoamines. In: Ito, U., Kirino, T., Kuroiwa, T., Klatzo, I. (eds) Maturation Phenomenon in Cerebral Ischemia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77134-7_18
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DOI: https://doi.org/10.1007/978-3-642-77134-7_18
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