Zusammenfassung
Im Vordergrund der biologischen Beurteilungsproblematik der Gliome stehen derzeit im wesentlichen zwei Themenkomplexe:
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Es gibt in Hinblick auf die Entwicklungslinien der unterschiedlichen Gliaformen im ausdifferenzierten Gehirn und die entsprechenden Signale, die für diese Differenzierung verantwortlich sind, noch keine verläßlichen Informationen.
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Man muß davon ausgehen, daß auch bei Gliomen, insbesondere bei den malignen Formen, einerseits eine Aktivierung bzw. sogar Überexpression von Genen nachweisbar ist, die den Zellen einen Wachstumsvorteil verleihen. Andererseits kommt es zu Funktionsverlusten von entscheidenden zellulären Kontrollgenen. Man kann dabei nicht sagen, welchem Phänomen die größere Bedeutung zukommt, oder ob die Ereignisse sogar verknüpft sind, d. h. daß die Gene, die einen Wachstumsvorteil vermitteln, dadurch angeschaltet werden, daß durch den Funktionsverlust eines Kontrollgenes ein zelluläres Programm aktiviert wird.
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Westphal, M., Hamel, W., Anker, L., Nausch, H., Zirkel, D., Herrmann, HD. (1992). Biologie der gliösen Hirntumoren: Experimentelle Ansätze bei der Therapie maligner Hirntumoren. In: Köhler, B., Keimer, R. (eds) Aktuelle Neuropädiatrie 1991. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77129-3_36
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