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The Regulation of Organelle Function Through Changes in Their Volume

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Book cover Advances in Comparative and Environmental Physiology

Part of the book series: Advances in Comparative and Environmental Physiology ((COMPARATIVE,volume 14))

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Abstract

Although a search of the literature provides evidence for morphological changes in many subcellular organelles in response to a variety of stimuli, the only subcellular organelle whose volume regulation has been studied in detail is the mitochondrion. For this organelle there is evidence for an important physiological role for volume regulation, thus this chapter will focus on the regulation of mitochondrial volume and its metabolic consequences. I will first review the mechanisms involved in volume homeostasis and secondly describe how, in the liver at least, mitochondrial volume may also be regulated by extrinsic factors such as hormones. I will then describe how such volume regulation may have profound effects on mitochondrial metabolism that are important for the overall effects of the hormones on liver metabolism. I will suggest that similar effects may follow changes in cellular volume such as those described by Haussinger (this Vol.). The evidence for changes in the mitochondrial volume induced by physiological stimuli in other tissues will also be reviewed briefly.

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  1. Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, UK

    A. P. Halestrap

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  1. Physiologisches Institut, Universität Tübingen, Gmelinstraße 5, W-7400, Tübingen, Germany

    Florian Lang

  2. Abteilung für Innere Medizin, Universität Freiburg, Hugstetterstraße 55, W-7800, Freiburg, Germany

    Dieter Häussinger

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Halestrap, A.P. (1993). The Regulation of Organelle Function Through Changes in Their Volume. In: Lang, F., Häussinger, D. (eds) Advances in Comparative and Environmental Physiology. Advances in Comparative and Environmental Physiology, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77124-8_9

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