Structure-Function Correlations of Colon and Distal Nephron

  • John P. Hayslett
Part of the Advances in Comparative and Environmental Physiology book series (COMPARATIVE, volume 16)


Intestinal epithelia and epithelia lining the nephron have a special attraction for membrane physiologists because of prominent structure-function correlations, unique segmental differentiation, and highly specialized functional differences between individual cell types within segments. This review aims to compare the similarities and differences in structure-function characteristics of epithelia in the colon and collecting duct system in the mammal. Our intent is to provide support for the proposition that the terminal segments of intestine and nephron, involved in the final regulation of electrolyte composition of fecal water and urine, employ anatomical structures and transport mechanisms for the regulation of transepithelial movement of electrolytes that are basically similar. Differences in structure and the incorporation of specialized cells are best explained by the unique roles played by intestine and kidney in the absorbance of nutrients as a source of energy and in overall regulation of water and electrolyte homeostasis, respectively. Details of molecular mechanisms that subserve ion transport will only be listed to the extent that they serve our aim, since they are comprehensively reviewed in other parts of this volume and elsewhere.


Apical Membrane Distal Colon Mineralocorticoid Receptor Proximal Colon Distal Nephron 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • John P. Hayslett
    • 1
  1. 1.Department of Internal Medicine, Section of NephrologyYale University School of MedicineNew HavenUSA

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