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Genotoxicity of Fe(III)-NTA and its Interaction with other Carcinogenic Metal Compounds

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Environmental Hygiene III


As an essential element in humans, iron is involved in many biochemical reactions; however, it is also known to catalyse the production of highly reactive oxygen species like hydroxyl radicals and superoxide anions, which produce DNA damage in cell free systems (Inoue and Kawanishi, 1987). Since in intact cells iron is mainly bound to storage proteins like ferritin and cellular defense systems exist to detoxify free oxygen radicals, toxic reactions in vivo are prevented to a high degree (for review see Halliwell and Gutteridge, 1984).

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  • Cook PR, Brazell IA (1976) Detection and repair of single-strand breaks in nuclear DNA. Nature 263: 679–682

    Article  CAS  Google Scholar 

  • Ebina Y, Okada S, Hamazaki S, Ogino F, Li J-I, Midorikawa O (1986) Nephrotoxicity and renal cell carcinoma after use of iron- and aluminum-nitrilotriacetate complexes in rats. J. Natl. Cancer Inst. 76: 107–113

    CAS  Google Scholar 

  • Eiinder CG (1986) Iron. In: Friberg L, Nordberg GF, Vouk VB (Eds) Handbook on the Toxicology of Metals, Elsevier, pp 276–297

    Google Scholar 

  • Halliwell B, Gutteridge JMC (1984) Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem. J. 219: 1–14

    CAS  Google Scholar 

  • Hamazaki S, Okada S, Li J-L, Toyokuni S, Midorikawa O (1989) Oxygen reduction and lipid peroxidation by iron chelates with special reference to ferric nitrilotriacetate. Arch. Biochem. Biophys. 272: 10–17

    Article  CAS  Google Scholar 

  • Hartwig A, Beyersmann D (1989a) Enhancement of UV-induced mutagenesis and sister-chromatid exchanges by nickel ions in V79 cells: evidence for inhibition of DNA repair. Mutation Res. 217: 65–73

    CAS  Google Scholar 

  • Hartwig A, Beyersmann D (1989b) Comutagenicity and inhibition of DNA repair by metal ions in mammalian cells. Biol. Trace Elem. Res. 21: 359–365

    Article  CAS  Google Scholar 

  • Inoue S, Kawanishi S (1987) Hydroxyl radical production and human DNA damage induced by ferric nitrilotriacetate and hydrogen peroxide. Cancer Res. 47: 6522–6527

    CAS  Google Scholar 

  • Misra M, Rodriguez RE, Kasprzak KS (1990) Nickel induced lipid peroxidation in the rat: correlation with nickel effect on antioxidant defense systems. Toxicology 64: 1–17

    Article  CAS  Google Scholar 

  • Nakatsuka S, Tanaka dH, Namba M (1990) Mutagenic effects of ferric nitrilotriacetate (Fe-NTA) on V79 Chinese hamster cells and its inhibitory effects on cell-cell communication. Carcinogenesis 11: 257–260

    Article  CAS  Google Scholar 

  • Planas-Bohne, F, Duffield J (1988) Factors influencing the uptake of iron and plutonium into cells. Int. J. Radiat. Biol. 53: 489–500

    Article  CAS  Google Scholar 

  • Sturrock A, Alexander J, Lamb J, Craven CM, Kaplan J (1990) Characterization of a transferrin-independent uptake system for iron in HeLa cells. J. Biol. Chem. 265: 3139–3145

    CAS  Google Scholar 

  • Umemura T, Sai K, Takagi A, Hasegawa R, Kurokawa Y (1990) Formation of 8-hydroxyguanosine (8-OH-dG) in rat kidney DNA after intraperitoneal administration of ferric nitrilotriacetate (Fe-NTA). Carcinogenesis 11: 345–347

    Article  CAS  Google Scholar 

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© 1992 Springer-Verlag Berlin Heidelberg

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Hartwig, A., Schlepegrell, R., Kuhlmann, J., Benters, J., Beyersmann, D. (1992). Genotoxicity of Fe(III)-NTA and its Interaction with other Carcinogenic Metal Compounds. In: Seemayer, N.H., Hadnagy, W. (eds) Environmental Hygiene III. Springer, Berlin, Heidelberg.

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77114-9

  • Online ISBN: 978-3-642-77112-5

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