Quantitation of 7-(2-Hydroxyethyl)guanine Produced by Endogenous and Environmental Ethylene Oxide in DNA of Lymphocytes

  • H. M. Bolt
  • H. Peter
  • M. Leutbecher
  • H. Ottenwälder
  • H. W. Goergens
  • U. Föst
Conference paper

Abstract

Analysis of macromolecular adducts of ethylene oxide is a tool which allows determination of internal target doses of this carcinogen (Bolt et al., 1988). An important aspect is that ethylene is converted in the living organism to ethylene oxide, and that ethylene is produced endogenously (Filser and Bolt, 1983; Schmiedel et al., 1983).

Keywords

Hydrolysis Phenol EDTA Adduct MeOH 

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • H. M. Bolt
    • 1
  • H. Peter
    • 1
  • M. Leutbecher
    • 1
  • H. Ottenwälder
    • 1
  • H. W. Goergens
    • 1
  • U. Föst
    • 1
  1. 1.Institut für Arbeitsphysiologie an der Universität DortmundDortmundGermany

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