Immunohistochemical Expression of Epidermal Growth Factor Receptor in Human Gliomas

  • J. Behnke
  • J. Bayer
  • H. Ludwig
  • B. Rama
Conference paper
Part of the Advances in Neurosurgery book series (NEURO, volume 20)


In the search for more specific tumor antigens, epidermal growth factor receptor (EGFR) mediated mechanisms have been found to play an important role for growth of malignancies. EGFR is a transmembrane mitogenic glycoprotein of 170 K. Besides the increased expression in human cervical, ovarian and vulval carcinomas [3], and human sarcomas [4] EGFR was found to be increased in human brain tumors [5].


Epidermal Growth Factor Receptor Malignant Glioma Human Glioma Epidermal Growth Factor Receptor Expression Epidermal Growth Factor Receptor Gene 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • J. Behnke
  • J. Bayer
  • H. Ludwig
  • B. Rama
    • 1
  1. 1.Neurochirurgische UniversitätsklinikGöttingenGermany

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