Correlation Between Cerebral Blood Flow Velocity in Basal Cerebral Arteries and Nimodipine Concentration in Serum and Plasma After Acute Subarachnoid Hemorrhage

  • D. Rosenthal
  • M. Carvi y Nievas
  • W. I. Steudel
  • A. Ricco
  • R. Lorenz
Conference paper
Part of the Advances in Neurosurgery book series (NEURO, volume 20)


Calcium channel blockers are being used to an increasing extent in neurosurgery to prevent vasospasm and cerebral ischemia secondary to subarachnoid hemorrhage. However, results reported from open or placebo-controlled studies show a wide variation with regard to the outcome [3, 4, 11, 13–17].


Calcium Antagonist Subarachnoid Hemorrhage Blood Flow Velocity Glasgow Outcome Scale Cerebral Blood Flow Velocity 
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  1. 1.
    Aaslid R, Markwalder TM, Nomes H (1982) Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries. J Neurosurg 57:969–774Google Scholar
  2. 2.
    Aaslid R, Huber P, Nornes H (1984) Evaluation of the cerebrovascular spasm with transcranial Doppler ultrasound. J Neurosurg 60:37–41PubMedCrossRefGoogle Scholar
  3. 3.
    Allen G, Ahn H, Preziosi T, Battye R, Boone S, Chou S, Kelly D, Weir B, Crabbe R, Mellits D, Bertsch L, Boisvert D, Hundley M, Johnson R, Strom J, Transou C (1983) Cerebral arterial vasospasm controlled trial of nimodipine in patients with subarachnoid hemorrhage. N Engl J Med 308:619–624PubMedCrossRefGoogle Scholar
  4. 4.
    Auer LM (1983) Cerebrovascular activity of the calcium antagonist nimodipine. In: Reivich M, Hurtig HI (eds) Cerebrovascular disease. Raven Press, New York, pp 375–384Google Scholar
  5. 5.
    Auer LM, Ito Z, Suzuki A, Ohta H (1982) Prevention of symptomatic vasospasm by topically applied nimodipine. Acta Neurochir 63:297–302CrossRefGoogle Scholar
  6. 6.
    Cohen RJ, Allen GS (1980) Cerebral arterial spasm: the role of calcium in vitro and in vivo analysis of treatment with nifedipine and nimodipine. In: Wilkins RH (ed) Cerebral arterial spasm. Williams & Wilkins, Baltimore, pp 527–532Google Scholar
  7. 7.
    Espinosa F, Weir B, Scnitka T, Overton T, Boisvert D (1984) A randomized placebo-controlled double-blind trial of nimodipine after SAH in monkeys. Part 2: Pathological findings. J Neurosurg 50:1176–1185Google Scholar
  8. 8.
    Giola E, White R, Bakhtian B, Robertson J (1985) Evaluation of the efficacy of intrathecal nimodipine in canine models of chronic cerebral vasospasm. J Neurosurg 62:721–728CrossRefGoogle Scholar
  9. 9.
    Hunt W, Hess R (1968) Surgical risk as related to time of intervention in the repair of intracranial aneurysms. J Neurosurg 28:14–19PubMedCrossRefGoogle Scholar
  10. 10.
    Jennett B, Bond M (1975) Assessment of outcome after severe brain damage. Lancet: 480–484Google Scholar
  11. 11.
    Kazner E, Sprung C, Adelt D, Ammerer HP, Karnick P, Baumann H, Böker DK, Grotenhuis JA, Jaksche H, Istaitih A (1985) Clinical experience with nimodipine in the prophylaxis of neurological deficits after subarachnoid hemorrhage. Neurochirurgia 28 (Suppl 1):110–113PubMedGoogle Scholar
  12. 12.
    Kunz U, Seifert V, Stolke D, Dietz H (1987) Intrathecal administration of nimodipine for treatment of chronic cerebral vasospasm (an experimental study). In: Isamat F, Ferrer E (eds) Proc VIII European Congress of Neurosurg. Barcelona, Spain, p 277 (abstr)Google Scholar
  13. 13.
    Ljunggren B, Brandt L, Säveland H, Nilsson PE, Cronquist S, Andersson KE, Vinge E (1984) Outcome in 60 consecutive patients treated with early aneurysm operation and intravenous nimodipine. J Neurosurg 61:864–873PubMedCrossRefGoogle Scholar
  14. 14.
    Ohman J, Heiskanen O (1988) Effect of nimodipine on the outcome of patients after aneurysmal subarachnoid hemorrhage and surgery. J Neurosurg 69:683–686PubMedCrossRefGoogle Scholar
  15. 15.
    Petruk KC, West M, Mohr G, Weir B, Benoit B, Gentili F, Disney L, Khan M, Grace M, Holness R, Karwon M, Ford R, Cameron G, Tucker W, Purves G, Miller J, Hunter M, Richard M, Durity F, Chan R, Clein L, Maroun F, Godon A (1988) Nimodipine treatment in poor grade aneurysm patients. Results of a multicenter double blind placebo-controlled trial. J Neurosurg 68:505–517PubMedCrossRefGoogle Scholar
  16. 16.
    Philippon J, Grob R, Dagreou F, Guggiari M, Rivierez M, Viars P (1986) Prevention of vasospasm in subarachnoid hemorrhage. A controlled study with nimodipine. Acta Neurochir 82:110–114CrossRefGoogle Scholar
  17. 17.
    Pickard J, Murray G, Illingworth R, Shaw M, Teasdale G, Foy P, Humphrey P, Lang D, Nelson R, Richards P, Sinar J, Bailey S, Skene A (1989) Effect of oral nimodipine on cerebral infarction and outcome after subarachnoid haemorrhage: British aneurysm nimodipine trial. Br Med J 298:636–642CrossRefGoogle Scholar
  18. 18.
    Raemsch KD, Graefe KH, Sommer J (1985) Pharmacokinetics and metabolism of nimodipine. In: Beth E, Deck K, Hoffmeister F (eds) Nimodipine, pharamcological and clinical properties. Schattauer, Stuttgart New York, pp 147–159Google Scholar
  19. 19.
    Steudel WI, Carvi y Nievas M, Tiyaworabun S, Lorenz R (1990) The prognostic significance of the concentration of nimodipine in the CSF and plasma in subarachnoid hemorrhage. In: Bushe KH, Brock M, Klinger M (eds) Advances in neurosurgery, vol 18. Springer, Berlin Heidelberg New York Tokyo, pp 180–184Google Scholar
  20. 20.
    Takayasu M, Bassett JE, Dacey RG Jr (1988) Effects of calcium antagonists on intracerebral penetrating arterioles in rats. J Neurosurg 69:104–109PubMedCrossRefGoogle Scholar

Copyright information

© pringer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • D. Rosenthal
  • M. Carvi y Nievas
  • W. I. Steudel
  • A. Ricco
  • R. Lorenz
    • 1
  1. 1.Neurochirurgische UniversitätsklinikFrankfurt/M. 71Germany

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