Cerebrovascular Reserve Capacity Measured with 133-Xenon Dynamic SPECT Before and After Carotid Endarterectomy
The role of surgery in patients with carotid artery disease remains controversial. Whereas it is generally agreed that endarterectomy is beneficial in patients with symptomatic conditions and ulcerative arteriosclerotic lesions, the optimal management of patients with stenotic lesions of the carotid artery has not been established yet. Previous randomized studies document that the spontaneous rate of stroke in patients with carotid artery stenoses is below 20% over a follow-up period of 2 years (Fields et al. 1970). The aim of the present study was to establish a functional test in order to identify patients with cerebral ischemia due to hemodynamic failure. Therefore, regional cerebral blood flow (rCBF; ml/100 g per minute) was measured at resting conditions and after stimulation with acetazolamide (Diamox) using the 133-xenon inhalation technique. Serial rCBF measurements were performed in a consecutive and unselected group of patients in order to study the effect of carotid endarterectomy on CBF and cerebrovascular reserve capacity.
KeywordsIschemia Neurol Xenon Acetazolamide Diamox
Unable to display preview. Download preview PDF.
- Leinsinger G, Schmiedek P, Kreisig T, Einhäupl K, Bauer W, Moser E (1988) 133-Xe-DSPECT: Bedeutung der zerebrovaskulären Reservekapazität für Diagnostik und Therapeutik der chronischen zerebralen Ischämie. Nucl Med 27:127–134Google Scholar
- Rutigliano MJ, Yonas H, Johnson DW (1989) Natural history of patients with compromised cerebral reserves. J Cereb Blood Flow Metab 9:S609Google Scholar