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Stimulated Cerebral Blood Flow pp 121–137Cite as

Positron Emission Tomography Activation Studies in Neurological Patients

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Abstract

The quantitative imaging of the hemodynamic and metabolic changes occurring in brain regions responding to distinct stimulation or involved in tie performance of specific tasks is one of the most intriguing applications of positron emission tomography (PET) (Phelps et al. 1982; Pawlik and Heiss 1989). Depending on the chosen paradigm, PET activation studies can serve many purposes. While elementary and stepwise paradigms are geared primarily at the elucidation of normal functional neuroanatomy, more complex tasks causing widespread activation may be better suited for the assessment of the regional reserve capacity especially in dysfunctional association areas because brain lesions are rarely restricted to primary cortex. Furthermore, even in regions showing no gross structrual abnormality, lesions at the cellular or synaptic level may interfere with the ability to respond to specific stimulation by appropriate neuronal recruitment that cannot be assessed with purely vascular stimuli like forced hypercapnia. This report describes our experience with a few cognitive and behavioral activation paradigms in various common neurological diseases.

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Authors
  1. G. Pawlik
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  2. G. R. Fink
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  3. U. Pietrzyk
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  4. M. Grond
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  5. W.-D. Heiss
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Editor information

Editors and Affiliations

  1. Neurochirurgische Klinik, Klinikum Großhadern, Marchioninistraße 15, 8000, München 70, Germany

    Peter Schmiedek

  2. Neurologische Klinik, Klinikum Großhadern, Marchioninistraße 15, 8000, Müchen 70, Germany

    Karl Einhäupl

  3. Radiologische Klinik, Klinikum Großhadern, Marchioninistraße 15, 8000, Münchn 70, Germany

    Carl-Martin Kirsch

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© 1992 Springer-Verlag, Berlin Heidelberg

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Pawlik, G., Fink, G.R., Pietrzyk, U., Grond, M., Heiss, WD. (1992). Positron Emission Tomography Activation Studies in Neurological Patients. In: Schmiedek, P., Einhäupl, K., Kirsch, CM. (eds) Stimulated Cerebral Blood Flow. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77102-6_14

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  • DOI: https://doi.org/10.1007/978-3-642-77102-6_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77104-0

  • Online ISBN: 978-3-642-77102-6

  • eBook Packages: Springer Book Archive

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