Advertisement

Die enterogene Endotoxinämie

  • D. Nitsche
  • M. Stehle
  • C. Schulze
  • S. Richter
Conference paper

Zusammenfassung

Zu den vielfältigen Funktionen des Intestinaltrakts gehört auch die Aufgabe, den Übertritt von Bakterien und Endotoxin aus dem Darmlumen in das Blut zu verhindern. Unter pathologischen Bedingungen, wie z. B. im Schock, kann es jedoch zu einem funktionellen Versagen der Mukosaschranke des Intestinaltrakts und damit zum Übertritt von Bakterien in das Blut kommen.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. 1.
    Baker JW, Deitch EA, Li M, Berg RD, Specian RD (1988) Hemorrhagic shock induces bacteria translocation from the gut. J Trauma 28:896–906PubMedCrossRefGoogle Scholar
  2. 2.
    Border JR, Hasset J, LaDuca J et al (1987) The gut origin septic states in blunt multiple trauma (ISS = 40) in the ICU. Ann Surg 206:427–445PubMedCrossRefGoogle Scholar
  3. 3.
    Carrico DJ, Meakins JL, Marshall JC, Fry D, Meier BV (1986) Multiple organ failure syndrom. Arch Surg 121:196–208PubMedGoogle Scholar
  4. 4.
    Deitch EA, Bridges RM (1987) Effect of stress and trauma on bacterial translocation from the gut. J Surg Res 42:536–542PubMedCrossRefGoogle Scholar
  5. 5.
    Deitch EA, Berg R, Specian RD (1987) Endotoxin promotes the translocation of bacteria from the gut. Arch Surg 122:185–190PubMedGoogle Scholar
  6. 6.
    Deitch EA, Morrison J, Berg R, Specian RD (1990) Effect of hemorrhagic shock on bacterial translocation, intestinal morphology, and intestinal permeability in conventional and antibiotic-decontaminated rats. Crit Care Med 18:529–536PubMedCrossRefGoogle Scholar
  7. 7.
    Jacob AI, Goldberg PK, Bloom N, Degenshein GA, Kozinn PJ (1977) Endotoxin and bacteria in portal blood. Gastroenterology 72:1268–1270PubMedGoogle Scholar
  8. 8.
    Messmer K, Kreimeier U, Hammersen F (1988) Multiple organ failure: Clinical implications to macro-and microcirculation. In: Manabe H, Zweifach BW, Messmer K (eds) Microcirculation in circulatory disorders. Springer, Berlin Heidelberg New York Tokyo, pp 147–157Google Scholar
  9. 9.
    Nitsche D, Kriewitz M, Rossberg A, Hamelmann H (1987) The quantitative determination of endotoxin in plasma samples of septic patients with peritonitits using the chromogenic substrate and its correlation with the clinical course of peritonitis. In: Watson SW, Levin J, Novitsky TJ (eds) Detection of bacterial endotoxins with the limulus amebocyte lysate test. Liss, New York, pp 417–429Google Scholar
  10. 10.
    Rietschel ET, Schade U, Jensen M, Wollenweber HW, Luderitz O, Greisman SG (1982) Bacterial endotoxins: chemical structure, biological activity and role in septicaemia. Scand J Infect Dis [Suppl] 31:8–21Google Scholar
  11. 11.
    Rush BF, Sori AJ, Murphy TF, Smith S, Flanagan JJ, Machiedo GW (1988) Endotoxemia and bacteremia during hemorrhagic shock. The link between trauma and sepsis? Ann Surg 207:549–554PubMedCrossRefGoogle Scholar
  12. 12.
    Rush BF, Redan JA, Flanagan JJ et al (1989) Does the bacteremia observed in hemorrhagic shock have clinical significance? A study in germ-free animals. Ann Surg 210:342–347PubMedCrossRefGoogle Scholar
  13. 13.
    Seifert J, Axt G, Bonacker P, Hamelmann H (1988) Einfluß der Immunsuppression auf die Resorption von Proteinen aus dem Magen-Darm-Trakt. Langenbecks Arch [Suppl] 345–349Google Scholar
  14. 14.
    Stoutenbeek CP, Saene HKF van, Miranda DR, Zanstrata DF (1984) The effect of selective decontamination of the digestive tract on colonisation and infection rate in multiple trauma patients. Intensive Care Med 10:185–192PubMedCrossRefGoogle Scholar
  15. 15.
    Triger DR, Boyer TD, Levin J (1978) Portal and systemic bacteremia and endotoxemia in liver disease. Gut 19:935–939PubMedCrossRefGoogle Scholar
  16. 16.
    Woodruff PW, O’Caroll DI, Koizumi S, Fine J (1973) Role of intestinal flora in major trauma. J Infect Dis 128:290–294PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • D. Nitsche
  • M. Stehle
  • C. Schulze
  • S. Richter

There are no affiliations available

Personalised recommendations