Ventricle Size and P300 in Elderly Depressed Patients
Despite the growing body of literature on computerized tomography (CT) studies and event related potentials (ERP) in mental diseases, little attention has been paid to the relationship between brain morphology and ERP. In schizophrenia no significant relationship between P300 latencies and CT scan measurements was detected (Romani et al. 1987), but positive correlations were described between N1-P2 amplitude and ventrical size. Romani et al. (1987) referred to analogous findings for visual evoked potentials of elderly and demented patients (Cosi et al. 1982). To our knowledge, these two studies are the only ones which have examined the relationship between CT measurements and ERP. Therefore, our study was planned in order to investigate the correlation between P300 and brain atrophy in elderly depressed patients.
KeywordsMedial Temporal Lobe Brief Psychiatric Rate Scale Demented Patient Sylvian Fissure Nontarget Stimulus
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