Changes in the Regional Activation Pattern in the Normal Human Brain During Dreaming and Rapid Eye Movement Sleep as Measured with Single Photon Emission Computerized Tomography

  • P. L. Madsen
  • L. Friberg
  • S. Holm
  • S. Vorstrup
  • N. A. Lassen
  • G. Wildschiødtz
Conference paper

Abstract

In the sleep-wake, cycle, rapid eye movement (REM) sleep represents a distinct mental condition, as it is closely correlated to the dream experience (Dement and Kleitman 1957). The present understanding of the dream phenomenon is very limited. We do not know the functional significance of dreams and the physiological state of the dreaming brain is largely unknown.

Keywords

Catheter Schizophrenia Serotonin Assure Neurol 

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References

  1. Berman KF, Zee RF, Weinberger DR (1986) Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia: II. Role of neuroleptic treatment, attention, and mental effort. Arch Gen Psychiatry 43:126–135PubMedGoogle Scholar
  2. Dement W, Kleitman N (1957) The relation of eye movements during sleep to dream activity: an objective method for the study of dreaming. J Exp Psychol 53:339–346PubMedCrossRefGoogle Scholar
  3. Hartmann E (1976) Schizophrenia: a theory Pschopharmacology (Berlin) 49:1–15CrossRefGoogle Scholar
  4. Jacobs BL, Trulson ME (1979) Dreams, hallucinations and psychosis – the serotonin connection. Trends Neurosci 2:277–280CrossRefGoogle Scholar
  5. Lassen NA, Ingvar DH (1978) Brain function and blood flow. Sci Am 239:62–72PubMedCrossRefGoogle Scholar
  6. Lassen NA, Andersen AR, Friberg L, Paulson OB (1988) The retention of [99 m-Tc]-d, 1-HM-PAO in the human brain after intracarotid bolus injection: kinetic analysis. J Cereb Blood Flow Metab 8:S13–S22PubMedCrossRefGoogle Scholar
  7. Lenzi P, Cianci T, Guidalotti PL, Leonardi GS, Franzini C (1987) Brain circulation during sleep and its relation to extracerebral hemodynamics. Brain Res 415: 14–20PubMedCrossRefGoogle Scholar
  8. Madsen PL, Holm S, Vorstrup, Friberg L, Lassen NA, Wildschiødtz G (1991a) Regional cerebral blood flow in man during rapid eye movement sleep. J Cereb Blood Flow Metab 11:502–507PubMedCrossRefGoogle Scholar
  9. Madsen PL, Schmidt JS, Wilschiødtz G, Friberg L, Holm S, Vorstrup S, Lassen NA (1991b) Cerebral O2 Metabolism and cerebral blood flow in humans during deep and rapid-eye-movement sleep. J Appl Physiology 70:2597–2607Google Scholar
  10. Olesen J (1971) Contralateral focal increase of cerebral blood flow in man during arm work. Brain 94:635–646PubMedCrossRefGoogle Scholar
  11. Phelps ME, Kuhl DE, Mazziotta JC (1981a) Metabolic mapping of the brain’s response to visual stimulation: studies in humans. Science 211:1445–1448PubMedCrossRefGoogle Scholar
  12. Phelps ME, Mazziotta JC, Kuhl DE, Nuwer M, Packwood J, Metter J, Engel J Jr (1981b) Tomographic mapping of human cerebral metabolism: visual stimulation and deprivation. Neurology 31:517–529PubMedGoogle Scholar
  13. Rechtschaffen A, Kales A (1968) A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects. UCLA Brain Information Service/Brain Research Institute, Los AngelesGoogle Scholar
  14. Reivich M, Isaacs G, Evarts E, Kety SS (1968) The effect of slow wave sleep and REM sleep on regional cerebral blood flow in cats. J Neurochem 15:301–306PubMedCrossRefGoogle Scholar
  15. Sakai F, Meyer JS, Karacan I, Derman S, Yamamoto M (1980) Normal human sleep: regional cerebral hemodynamics. Ann Neurol 7:471–478PubMedCrossRefGoogle Scholar
  16. Santiago TV, Guerra E, Neubauer JA, Edelman NH (1984) Correlation between ventilation and brain blood flow during sleep. J Clin Invest 73:497–506PubMedCrossRefGoogle Scholar
  17. Sokoloff L (1981) The relationship between function and energy metabolism: its use in the localization of functional activity in the nervous system. Neurosci Res Prog Bull 19:159–210Google Scholar
  18. Townsend RE, Prinz PN, Obrist WD (1973) Human cerebral blood flow during sleep and waking. J Appl Physiol 35:620–625PubMedGoogle Scholar
  19. Weinberger DR, Berman KF, Zee RF (1986) Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia: I. Arch Gen Psychiatry 43:114–124PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • P. L. Madsen
    • 1
  • L. Friberg
  • S. Holm
  • S. Vorstrup
  • N. A. Lassen
  • G. Wildschiødtz
  1. 1.Department of Clinical PhysiologyBispebjerg HospitalCopenhagen NVDenmark

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