Chronic Megakaryocytic-Granulocytic Myelosis: Accuracy of Clinical Diagnosis of Chronic Myeloproliferative Disorders with Thrombocytosis
Chronic megakaryocytc granulocytic myelosis (CMGM) is characterized by a bilinear proliferation of granulocyte- and megakaryocytopoiesis originally described by Georgii et al. [1,2]. Histopathological bone marrow examination reveals moderate to high-grade augmentation of megakaryocytes which are polymorphous and extremely atypical. Megakaryocytopoesis shows an abnormal extension towards the osseous trabecula. Neutrophilic granulo-cytopoiesis is conspicuously increased and hyperplastic. These histopathological features allow one to separate this entity from other chronic myeloproliferative disorders (CMPD) with thrombocytosis such as chronic granulocytic leukemia (CGL) with thrombocytosis, essential thrombo-cythemia (ETH), polycythemia vera (PV), and agnogenic myeloid metaplasia (AMM). Aim of this study was to compare clinical and histopathological diagnoses of CMPD with thrombocytosis in order to find out how accurately purely clinical diagnosis of CMGM could be carried out.
KeywordsChronic Myeloid Leukaemia Polycythemia Vera Spleen Size Bone Marrow Specimen Polycythemia Vera Patient
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