Leukemias pp 281-283 | Cite as

Chronic Megakaryocytic-Granulocytic Myelosis: Accuracy of Clinical Diagnosis of Chronic Myeloproliferative Disorders with Thrombocytosis

  • H. L. Seewann
  • C. Schmid
Conference paper

Abstract

Chronic megakaryocytc granulocytic myelosis (CMGM) is characterized by a bilinear proliferation of granulocyte- and megakaryocytopoiesis originally described by Georgii et al. [1,2]. Histopathological bone marrow examination reveals moderate to high-grade augmentation of megakaryocytes which are polymorphous and extremely atypical. Megakaryocytopoesis shows an abnormal extension towards the osseous trabecula. Neutrophilic granulo-cytopoiesis is conspicuously increased and hyperplastic. These histopathological features allow one to separate this entity from other chronic myeloproliferative disorders (CMPD) with thrombocytosis such as chronic granulocytic leukemia (CGL) with thrombocytosis, essential thrombo-cythemia (ETH), polycythemia vera (PV), and agnogenic myeloid metaplasia (AMM). Aim of this study was to compare clinical and histopathological diagnoses of CMPD with thrombocytosis in order to find out how accurately purely clinical diagnosis of CMGM could be carried out.

Keywords

Leukemia Methacrylate Thrombocytosis Polycythemia Myelofibrosis 

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References

  1. 1.
    Georgii A, Vykoupil KF, Thiele J (1980) Chronic megakaryocytic granulocytic myelosis — CMGM. A subtype of chronic myeloid leukaemia. Virchows Arch [A] 389:253–268CrossRefGoogle Scholar
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    Georgii A (1983) Histopathologic und Klinik der chronischen, myeloproliferativen Erkrankungen. Verh Dtsch Ges Pathol 67:214–234PubMedGoogle Scholar
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    Jamshidi K, Swaim WR (1971) Bone marrow biopsy with unaltered architecture: a new biopsy device. J Lab Clin Med 77:335–342PubMedGoogle Scholar
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    Seewann HL, Lehnert M, Jüttner F (1983) The value of bone marrow biopsy in chronic myeloid leukaemia. Haematologia 16:67–72PubMedGoogle Scholar
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    Seewann HL (1986) Die Jamshidibiopsie in der klinischen Hämatologie. Wien Med Wochenschr 136[Suppl]:100Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • H. L. Seewann
    • 1
  • C. Schmid
  1. 1.Medizinische Abteilung III des Landeskrankenhauses und Pathologisch-Anatomisches Institut der UniversitätGrazAustria

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