Leukemias pp 15-17 | Cite as

Nucleolar Organizer Regions in Acute Leukemia

  • M. Trněný
  • K. Smetana
Conference paper


Nucleolar organizer regions (NORs) are loops of DNA which occur in the cell nucleolus and contain ribosomal RNA genes [1]. These regions can be demonstrated by reaction of NOR protein components with silver [6,9]. In light microscopy they appear as intensely stained brown or black granules called either silver-NORs (Ag-NORs) or silver-stained granules (SSGs). Their number is apparently related to nucleolar biosynthetic activity with respect to ribosomal RNA transcription [9]. The number of SSGs has been studied in metaphases of normal and leukemic bone marrow, and the silver stainability in interphasic leukemic cells has been also investigated in several studies (e.g., 2, 7). There are, however, some differences in the results of these studies. The aim of our study was to provide more information on the number of nucleolar SSGs in interphasic leukemic myeloblasts in the peripheral blood.


Acute Myeloid Leukemia Acute Leukemia Silver Staining Nucleolar Organizer Region Human Bone Marrow Cell 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • M. Trněný
    • 1
  • K. Smetana
    • 1
  1. 1.Institute of Hematology and Blood TransfusionPragueCzechoslovakia

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