Leukemias pp 213-218 | Cite as

Cellular Pharmacokinetics of Daunomycin in Human Leukemic Blasts In Vitro and In Vivo

  • M. E. Scheulen
  • B. Kramer
  • M. Skorzec
  • W. K. Reich
Conference paper


The description of a decrease in the intracellular accumulation of a number of cytostatics, such as anthracyclines, vinca alkaloids, epipodophyllotoxins, and actinomycin D, in drug-resistant malignant cells, which was first demonstrated for colchicine in Chinese hamster ovary cells [4], has substantially contributed to the understanding of “multidrug resistance” [6]. This process is caused by an energy-dependent outward pump in connection with the expression of the 170000-Da plasma membrane glycoprotein P170 [21].


Acute Myeloid Leukemia Chinese Hamster Ovary Cell Acute Myelogenous Leukemia Intracellular Accumulation Cytosine Arabinoside 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • M. E. Scheulen
    • 1
  • B. Kramer
  • M. Skorzec
  • W. K. Reich
  1. 1.Department of Internal Medicine (Cancer Research), West German Tumor CenterUniversity of Essen Medical SchoolEssenGermany

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