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Pathophysiology and Pharmacology of Erythropoietin pp 263–269Cite as

Effects of Inflammatory Cytokines on the Production of Erythropoietin

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Abstract

Chronic infections, autoimmune diseases, and malignancies are frequently associated with a mild hypoplastic anemia. The causes of this so-called anemia of chronic disorders (ACD) include impaired ability of erythrocytic precursors to utilize iron for hemoglobin synthesis, inhibition of the proliferation of myeloid cells by inflammatory cytokines, hemolysis, and often bleeding. Furthermore, earlier bioassay studies showed that the plasma level of erythropoietin (Epo) is relatively low for the degree of the anemia in many patients suffering from chronic inflammation or malignancy [24, 33, 34]. Radioimmunological investigations have confirmed that there is a relative lack of Epo in rheumatoid arthritis [1, 12, 29], acquired immunodeficiency syndrome [28], and cancer [20].

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Authors
  1. W. Jelkmann
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  2. J. Fandrey
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  3. H. Pagel
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Editor information

Editors and Affiliations

  1. Institut für Physiologie, Medizinische Universität zu Lübeck, Ratzeburger Allee 160, W-2400, Lübeck 1, Germany

    Horst Pagel  & Christoph Weiss  & 

  2. Physiologisches Institut I, Rheinische Friedrich-Wilhelms-Universität, Nußallee 11, W-5300, Bonn 1, Germany

    Wolfgang Jelkmann

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© 1992 Springer-Verlag Berlin Heidelberg

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Jelkmann, W., Fandrey, J., Pagel, H. (1992). Effects of Inflammatory Cytokines on the Production of Erythropoietin. In: Pagel, H., Weiss, C., Jelkmann, W. (eds) Pathophysiology and Pharmacology of Erythropoietin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77074-6_32

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  • DOI: https://doi.org/10.1007/978-3-642-77074-6_32

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77076-0

  • Online ISBN: 978-3-642-77074-6

  • eBook Packages: Springer Book Archive

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