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Mechanism and Control of Cellular DNA Replication

  • Conference paper
DNA Replication and the Cell Cycle

Part of the book series: Colloquium der Gesellschaft für Biologische Chemie ((MOSBACH,volume 43))

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Abstract

Our understanding of DNA replication in bacteria has relied heavily upon studies on the replication of bacteriophage and plasmid chromosomes and the ability to compare and contrast the mechanisms of DNA synthesis and the functions of the replicative enzymes. In much the same way, studies of the mammalian DNA viruses have contributed to an understanding of the enzymology of cellular DNA replication. The choice model system to date for understanding the enzymology of eukaryotic DNA replication has been the study of Simian Virus 40 (SV40) DNA replication. This is due to the fact that SV40 DNA exists in the cell as a small, circular chromosome that can be thought of as the equivalent of a single replicon within the larger cellular chromosomes. Furthermore, SV40 DNA exists in a chromatin structure that resembles the structure of cellular chromatin and therefore could be a useful model for chromosome, as well as DNA replication (Stillman 1986; DePamphilis and Bradley 1986; Cheng and Kelly 1989; Smith and Stillman 1989).

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  1. Cold Spring Harbor Laboratory, 11724, Cold Spring Harbor, New York, USA

    B. Stillman

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  1. B. Stillman
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  1. Institut für Biochemie, Karlstraße 23, 8000, München, Germany

    Ellen Fanning

  2. Fakultät für Biologie, Universität Konstanz, 7750, Konstanz, Germany

    Rolf Knippers

  3. Institut für Biochemie LMU, Max-Planck-Institut für Biochemie, Am Klopferspitz, 8033, Martinsried, Germany

    Ernst-L. Winnacker

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Stillman, B. (1993). Mechanism and Control of Cellular DNA Replication. In: Fanning, E., Knippers, R., Winnacker, EL. (eds) DNA Replication and the Cell Cycle. Colloquium der Gesellschaft für Biologische Chemie, vol 43. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77040-1_10

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  • DOI: https://doi.org/10.1007/978-3-642-77040-1_10

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