Abstract
In the last quarter of the nineteenth century several workers described the heatlabile lytic action of serum on bacteria and erythrocytes, and it was these observations which led to the discovery of the complement system (Nuttal 1888; Bordet 1898; Ehrlich and Morgenroth 1899). These lytic activities were subsequently shown to be mediated by the final stage in the complement system, the membrane attack complex (MAC). Given this history it is therefore perhaps not surprising that, until very recently, the MAC was considered by the majority of immunologists to be a lytic entity, the sole role of which was kill target cells. The concept that the MAC might cause more subtle (and often more pathologically relevant) changes in target cells has only recently gained widespread acceptance. The concept is of particular relevance when the targets are nucleated and metabolically active, although important nonlethal changes may also be induced in non-nucleated cells (see Chap. 7).
Keywords
- Membrane Attack Complex
- Reactive Oxygen Metabolite
- Glomerular Epithelial Cell
- Terminal Complement Complex
- Ehrlich Cell
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Morgan, B.P. (1992). Effects of the Membrane Attack Complex of Complement on Nucleated Cells. In: Parker, C.J. (eds) Membrane Defenses Against Attack by Complement and Perforins. Current Topics in Microbiology and Immunology, vol 178. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77014-2_8
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