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Genetic Diversity and Rapid Evolution of Poliovirus in Human Hosts

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Genetic Diversity of RNA Viruses

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 176))

Abstract

Rapid changes in phenotypic markers of polioviruses during replication in man were already reported in the 1950s but studies examining the mode and rate of genetic variation of the viruses only started in the 1980s. Recent studies have revealed that like other RNA viruses, polioviruses show typical features of a quasispecies with a multitude of variants present in a host at a given time and drifts in the composition of the mixture in relation to time. In this review we discuss the pattern of genetic variation of polioviruses and its relation to virus-host relationships.

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Author information

Authors and Affiliations

  1. Enterovirus Laboratory, Department of Virology and Molecular Biology Unit, National Public Health Institute, Mannerheimintie 166, 00300, Helsinki, Finland

    L. Kinnunen, T. Pöyry & T. Hovi

Authors
  1. L. Kinnunen
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  2. T. Pöyry
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  3. T. Hovi
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Editor information

Editors and Affiliations

  1. Department of Biology, C-016, University of California, 92093, San Diego, La Jolla, CA, USA

    John J. Holland Ph.D. (Professor of Biology and Molecular Genetics) (Professor of Biology and Molecular Genetics)

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© 1992 Springer-Verlag Berlin · Heidelberg

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Kinnunen, L., Pöyry, T., Hovi, T. (1992). Genetic Diversity and Rapid Evolution of Poliovirus in Human Hosts. In: Holland, J.J. (eds) Genetic Diversity of RNA Viruses. Current Topics in Microbiology and Immunology, vol 176. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77011-1_4

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  • DOI: https://doi.org/10.1007/978-3-642-77011-1_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77013-5

  • Online ISBN: 978-3-642-77011-1

  • eBook Packages: Springer Book Archive

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