Theoretical Insight into Antigen-Induced T-Cell Unresponsiveness

  • M. Kaufman
  • F. Andris
  • O. Leo
Part of the NATO ASI Series book series (volume 66)


It is now well established that immune responses involve intricate, highly regulated interactions between functionally different sets and subsets of lymphocytes. The available evidences indicate that helper T lymphocytes, in particular, play an essential role in the initiation of most antibody or cell mediated responses. Activation of mature T helper cells leads to the production of regulatory factors that have an effect on the activation and function of other cells of the immune system. Numerous studies therefore are devoted to the conditions of activation and inactivation of these lymphocytes. In the present work we focus more specifically on the induction of long-lasting unresponsiveness after interaction of Interleukin-2 (I1–2) producing T helper cells with antigen. This phenomenon is important for the downregulation of a normal immune response, and might also participate in the mechanisms of self-tolerance.


Phosphatidyl Inositol Receptor Form Zeta Chain Costimulatory Factor Total Receptor Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Additional Abbreviations




Major Histocompatibility Complex


monoclonal antibody


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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • M. Kaufman
    • 1
  • F. Andris
    • 1
    • 2
  • O. Leo
    • 1
    • 2
  1. 1.Service de Chimie PhysiqueUniversité Libre de BruxellesBruxellesBelgium
  2. 2.Laboratoire de Physiologie AnimaleUniversité Libre de BruxellesRhode St GenèseBelgium

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