Theoretical Insight into Antigen-Induced T-Cell Unresponsiveness
It is now well established that immune responses involve intricate, highly regulated interactions between functionally different sets and subsets of lymphocytes. The available evidences indicate that helper T lymphocytes, in particular, play an essential role in the initiation of most antibody or cell mediated responses. Activation of mature T helper cells leads to the production of regulatory factors that have an effect on the activation and function of other cells of the immune system. Numerous studies therefore are devoted to the conditions of activation and inactivation of these lymphocytes. In the present work we focus more specifically on the induction of long-lasting unresponsiveness after interaction of Interleukin-2 (I1–2) producing T helper cells with antigen. This phenomenon is important for the downregulation of a normal immune response, and might also participate in the mechanisms of self-tolerance.
KeywordsHydrolysis Tyrosine Immobilization Oligomerization Polypeptide
Major Histocompatibility Complex
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