Experimental and Theoretical Investigations on Idiotypic Mimicry

  • Alf Grandien
  • Antonio Coutinho
  • John Stewart
Part of the NATO ASI Series book series (volume 66)


This will be a progress report on some intriguing data concerning idiotypic mimicry in immunoglobulin transgenic mice, and on the genesis of a model of the immune system where similar phenomena can be simulated. We think that the observations on idiotypic mimicry are something more than a curiosity of “idiotypic cascades” in transgenic mice; rather, we believe that such simplified model systems can help us understand the basic rules on which an extremely complex immune system is built and learns self-tolerance through V-region repertoire selection.


Immune Network Trans Gene Limit Dilution Analysis Idiotypic Interaction Repertoire Selection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • Alf Grandien
    • 1
    • 2
  • Antonio Coutinho
    • 2
  • John Stewart
    • 2
  1. 1.Department of ImmunologyUniversity of UppsalaSweden
  2. 2.Unité d’ImmunobiologieCNRS URA 359, Institut PasteurParisFrance

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