Experimental and Theoretical Investigations on Idiotypic Mimicry
This will be a progress report on some intriguing data concerning idiotypic mimicry in immunoglobulin transgenic mice, and on the genesis of a model of the immune system where similar phenomena can be simulated. We think that the observations on idiotypic mimicry are something more than a curiosity of “idiotypic cascades” in transgenic mice; rather, we believe that such simplified model systems can help us understand the basic rules on which an extremely complex immune system is built and learns self-tolerance through V-region repertoire selection.
Unable to display preview. Download preview PDF.
- De Boer, R. J., and Perelson, A. S. (1990) Size and connectivity as emergent properties of a developing immune network. J. Theoret. Biol.Google Scholar
- Jerne, N. K. (1971) What precedes clonal selection ? In Ciba Foundation Symposium: Ontogeny of acquired immunity. Elsevier, Amsterdam, pp. 1.Google Scholar
- Varela, F., A. Coutinho, B. Dupire and N. Vaz. (1988) Cognitive networks: immune, neural and otherwise. In In Theoretical Immunology. A. S. Perelson, A. S. Perelson. Addison-Wesley Publ. Co., Inc., Redwood City. 359.Google Scholar