Experimental and Theoretical Investigations on Idiotypic Mimicry
This will be a progress report on some intriguing data concerning idiotypic mimicry in immunoglobulin transgenic mice, and on the genesis of a model of the immune system where similar phenomena can be simulated. We think that the observations on idiotypic mimicry are something more than a curiosity of “idiotypic cascades” in transgenic mice; rather, we believe that such simplified model systems can help us understand the basic rules on which an extremely complex immune system is built and learns self-tolerance through V-region repertoire selection.
KeywordsImmune Network Trans Gene Limit Dilution Analysis Idiotypic Interaction Repertoire Selection
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