Experimental and Theoretical Investigations on Idiotypic Mimicry

  • Alf Grandien
  • Antonio Coutinho
  • John Stewart
Part of the NATO ASI Series book series (volume 66)

Abstract

This will be a progress report on some intriguing data concerning idiotypic mimicry in immunoglobulin transgenic mice, and on the genesis of a model of the immune system where similar phenomena can be simulated. We think that the observations on idiotypic mimicry are something more than a curiosity of “idiotypic cascades” in transgenic mice; rather, we believe that such simplified model systems can help us understand the basic rules on which an extremely complex immune system is built and learns self-tolerance through V-region repertoire selection.

Keywords

Acetyl Dextran 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • Alf Grandien
    • 1
    • 2
  • Antonio Coutinho
    • 2
  • John Stewart
    • 2
  1. 1.Department of ImmunologyUniversity of UppsalaSweden
  2. 2.Unité d’ImmunobiologieCNRS URA 359, Institut PasteurParisFrance

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