Abstract
The cryptic self represents those poorly presented antigenic determinants that exist within the organism, against which the T cell repertoire has not been rendered tolerant. Occasional availability of certain cryptic determinants may have a detrimental consequence and cause autoimmunity. On the other hand, cryptic determinants may be able to be harnessed to perform worthwhile tasks such as raising anti-tumor responsiveness.
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References
Benichou, G., Takizawa, P.A., Ho, P.T., Killion, C.C., Olson, C.A. McMillan, M. amp; Sercarz, E. (1990) Immunogenicity and tolerogenicity of self-MHC peptides. J. Exp. Med. 172: 1341–1346.
Benichou, G., Takizawa, P.A., Olson, C.A., McMillan, M. amp; Sercarz, E.E. (1992) Donor MHC peptides are presented by recipient MHC molecules during graft rejection. J. Exp. Med. 175: 305–308.
Benichou, G., Fedoseyeva, E., Olson, C.A., Geysen, M., McMillan, M. amp; Sercarz, E. Intramolecular competition between self-peptides and regulation of tolerance induction. (Manuscript in preparation)
Bhardwaj, V., Kumar, V., Geysen, H.M. amp; Sercarz, E.E. (1992) Subjugation of dominant immunogenic determinants within a chimeric peptide. ( Submitted )
Bhardwaj, V., Kumar, V. amp; Sercarz, E. Molecular mimicry in the absence of protein sequence homology. (Manuscript in preparation.)
Bishop, J. M. (1991) Molecular themes in oncogenesis. Cell 64: 235.
Bos, J. L. (1988) The ras gene family and human carcinogegesis. Mutat. Res. 195 (3): 255.
Cibotti, R., Kanellopoulos, J., Cabaniois, J-P., Halle-Panenko, O., Kosmatopoulos, K., Sercarz, E. amp; Kourilsky, P. (1992) Tolerance to a self-protein involves its immunodominant but not subdominant determinants. PNAS (in press).
Dausset, J. (1981) The major histocompatibility complex in man. Science 213: 1469.
Gammon, G. amp; Sercarz, E. (1989) How some T-cells escape tolerance induction. Nature 342: 183–185.
Gammon, G., Sercarz, E. amp; Benichou, G. (1991) The specificity of the autoreactive T cell repertoire: The dominant self and the cryptic self. Immunology Today 12: 193–195.
Hellstrom, K. E. amp; Hellstrom, I. (1989) Oncogene-associated tumor antigens as targets for immunotherapy. FASEB Journal 3 (6): 1715–1722.
Hollstein, M., Sidransky, D., Vogelstein, B. amp; Harris, C.C. (1991) P53 mutations in human cancers. Science 253 (5015): 49–53.
Jung, S. amp; Schleusener, H. J. (1991) Human T lymphocytes recognize a peptide of single point-mutated, oncogenic ras proteins. J. Exp. Med. 173: 273–276.
Kourilsky, P. amp; Claverie, J.M. (1989) MHC restriction, alloreactivity, and thymic education: a common link? Cell. 56: 327–329.
Matzinger, P. amp; Bevan, M. (1977) Why do so many lymphocytes respond to major histocompatibility antigens? Cell. Immunol. 29: 1.
Melief, C. J. M. amp; Kast W.M. (1991) Lessons from T cell responses to virus-induced tumors for cancer eradication in general. Cancer Surveys (in press).
Peace, D. J., Chen, W., Nelson, H. amp; Cheever, M.A. (1991) Tcell recognition of transforming proteins encoded by mutated ras proto-oncogenes. J. Immunology 146 (6): 2059–2065.
Snell, G.D. (1981) Studies in histocompatibility. Science 213: 172.
Van Den Eynde, B., Lethe, B., Van Pel, A., De Plaen, E. amp; Boon, T. (1991) The gene coding for a major tumor rejection antigen of tumor P815 is identical to the normal gene of syngeneic DBA/2 mice. J. Exp. Med. 173: 1373–1384.
Van Der Bruggen, P., Traversari, C., Chomez, P., Lurquin, C., De Plaen, Van Den Eynde, B., Knuth, A. amp; Boon T. (1991) A gene encoding an antigen recognized by cytoloytic T lymphocytes on a human melanoma. Science 254 (5038): 1643–1647.
Van Pel, A., Vessiere, F. amp; Boon, T. (1983) Protection against two spontaneous mouse leukemias conferred by immunogenic variants obtained by mutagenesis. J. Exp. Med 157: 992–2001
Wraith, D.C., Smilek, D.E., Mitchell, D.J., Steinman, L. amp; McDevitt, H.O. (1989) Antigen recognition in autoimmune encephalomyelitis and the potential for peptide mediated immunotheraypy. Cell 59: 247–255
Zamvil, S.S., Mitchell, D.J., Lee, N.E., Moore, A.C., Kitamura, K., Steinman, L. amp;amp; Rothbard, J.B. (1986) T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis. Nature 324: 258–260.
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© 1992 Springer-Verlag Berlin Heidelberg
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Benichou, G., Bhardwaj, V., Schoenberger, S.P., Sercarz, E.E. (1992). The Secrets of Crypticity and its Relationship to Medical Problems: Autoimmune Disease, Transplantation and Cancer. In: Perelson, A.S., Weisbuch, G. (eds) Theoretical and Experimental Insights into Immunology. NATO ASI Series, vol 66. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76977-1_27
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DOI: https://doi.org/10.1007/978-3-642-76977-1_27
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