A Structure-Function Analysis of BtuB, the E.Coli. Vitamin B12 Outer Membrane Transport Protein

  • R. J. Ward
  • S. E. Hufton
  • N. A. C. Bunce
  • A. J. P. Fletcher
  • R. E. Glass
Part of the NATO ASI Series book series (volume 65)


Vitamin B12 or cobalamin is a member of a group of compounds known as the corrinoids which are the most complex, nonpolymeric molecules so far found in nature. They exist in trace amounts throughout the natural world, usually within the concentration range lxl0-9 to 1x10-15 (Bradbeer, 1982). Vitamin B12 is found in virtually all animal tissues to a greater or lesser degree, its source being ingested tissue or synthesis by gut flora.


Codon Tyrosine Serine Lysine Polypeptide 


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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • R. J. Ward
    • 1
  • S. E. Hufton
    • 1
  • N. A. C. Bunce
    • 1
  • A. J. P. Fletcher
    • 1
  • R. E. Glass
    • 1
  1. 1.Department of BiochemistryUniversity of Nottingham Medical SchoolNottinghamEngland

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