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In Vivo Properties of Colicin A: Channel Activity and Translocation

  • Conference paper
Bacteriocins, Microcins and Lantibiotics

Part of the book series: NATO ASI Series ((ASIH,volume 65))

Abstract

Colicin A belongs to the group of colicins which form voltage dependent ionic channels in planar lipid bilayers. (Schein et al., 1978; Pattus et al., 1983). In vivo, the primary effects of these colicins are a leakage of cytoplasmic K+ (Wendt, 1970) and small ions (Lusk and Nelson, 1972), a decrease of internal ATP, a collapse of the electrochemical gradient of protons (Δ μH +), and consequently an inhibition of the ΔμH+-driven active transport systems (for reviews see Luria, 1975; Konisky, 1978, 1982). On the basis of these in vitro and in vivo properties, it is generally admitted that the killing activity of these colicins results from the formation of channels in the cytoplasmic membrane.

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Author information

Authors and Affiliations

  1. Laboratoire des Biomembranes, Bat 433, URA.CNRS 1116 Université Paris Sud, 91405, Orsay Cedex, France

    L. Letellier & P. Boulanger

  2. Centre de Biochimie et de Biologie Moleculaire du CNRS, 31 Chcmin Joseph Aiguier, BP.71, 13402, Marseille Cedex 9, France

    C. Lazdunski, H. Benedetti & J. P. Bourdineaud

Authors
  1. L. Letellier
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  2. C. Lazdunski
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  3. H. Benedetti
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  4. J. P. Bourdineaud
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  5. P. Boulanger
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Editor information

Editors and Affiliations

  1. School of Biological Sciences, University of East Anglia, Norwich, Norfolk, NR4 7TJ, UK

    Richard James

  2. Centre National de la Recherche Scientifique, Centre de Biochimie et de Biologie Moléculaire, 31, chemin Joseph Aiguier, B. P. 71, 13402, Marseille Cédex 9, France

    Claude Lazdunski

  3. European Molecular Biology Laboratory, Meyerhofstrasse 1, Postfach 10 22 09, 6900, Heidelberg, Germany

    Franc Pattus

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© 1992 Springer-Verlag Berlin Heidelberg

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Letellier, L., Lazdunski, C., Benedetti, H., Bourdineaud, J.P., Boulanger, P. (1992). In Vivo Properties of Colicin A: Channel Activity and Translocation. In: James, R., Lazdunski, C., Pattus, F. (eds) Bacteriocins, Microcins and Lantibiotics. NATO ASI Series, vol 65. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76974-0_13

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  • DOI: https://doi.org/10.1007/978-3-642-76974-0_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76976-4

  • Online ISBN: 978-3-642-76974-0

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