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GABA and Diamine Oxidase Activity in the Gastrointestinal Mucosa: Possible Links

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GABA Outside the CNS

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Abstract

Gamma-aminobutyric acid (GABA) has a transmitter function in the mammalian enteric nervous system. The intestine contains endogenous GABA [1, 24, 32] and its synthesizing and degrading enzymes, i.e., glutamic acid decarboxylase (GAD, EC 4.1.1.15) [24, 32] and GABA-transaminase (GABA-T, EC 2.6.1.19) [32], respectively. Endogenous and labeled GABA may be released from the intestine by electrical transmural Stimulation [44] or by the application of substance P [43]. Finally, the presence of GABAergic neurons in the intestine has been demonstrated by immunohistochemical methods [3, 10, 23]. GABA may act on both inhibitory and excitatory neurons of the enteric plexus [26] and these effects appear to be mediated by both subtypes of GABA receptors, i.e., GABAA and GABAB [25].

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Authors
  1. W. A. Fogel
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  2. S. L. Erdö
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Editors and Affiliations

  1. Department of Anatomy, University of Göttingen, Kreuzbergring 36, W-3400, Göttingen, Germany

    Sándor L. Erdö Ph.D.

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© 1992 Springer-Verlag Berlin Heidelberg

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Fogel, W.A., Erdö, S.L. (1992). GABA and Diamine Oxidase Activity in the Gastrointestinal Mucosa: Possible Links. In: Erdö, S.L. (eds) GABA Outside the CNS. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76915-3_9

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  • DOI: https://doi.org/10.1007/978-3-642-76915-3_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76917-7

  • Online ISBN: 978-3-642-76915-3

  • eBook Packages: Springer Book Archive

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