GABAergic Mechanisms in the Pulmonary System
GABA is a well known inhibitory neurotransmitter in the central nervous system (CNS) that has recently been detected in a variety of peripheral organs . In the lung, GABA has also been implicated as an inhibitory neurotransmitter. It attenuates the contractile response of the isolated guinea-pig trachea to electrical field Stimulation [8, 22, 23], inhibits the release of acetylcholine from guinea-pig lungs , and reduces bronchoconstrictor responses to nonadrenergic, noncholinergic Stimulation in guinea-pig airways . However, there is no consensus as to whether the effects of GABA are mediated through an interaction with the well characterized GABAA receptor or rather with the GABAB receptor whose function is not as well understood . In this chapter, we will review the status of GABA as an inhibitory neurotransmitter in the pulmonary system and provide support for GABAB receptors as functionally important for the inhibitory effects of GABA.
KeywordsGABAs Receptor Airway Smooth Muscle GABAB Receptor Electrical Field Stimulation Vagal Nerve Stimulation
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