GABAergic Mechanisms in the Pulmonary System
GABA is a well known inhibitory neurotransmitter in the central nervous system (CNS) that has recently been detected in a variety of peripheral organs . In the lung, GABA has also been implicated as an inhibitory neurotransmitter. It attenuates the contractile response of the isolated guinea-pig trachea to electrical field Stimulation [8, 22, 23], inhibits the release of acetylcholine from guinea-pig lungs , and reduces bronchoconstrictor responses to nonadrenergic, noncholinergic Stimulation in guinea-pig airways . However, there is no consensus as to whether the effects of GABA are mediated through an interaction with the well characterized GABAA receptor or rather with the GABAB receptor whose function is not as well understood . In this chapter, we will review the status of GABA as an inhibitory neurotransmitter in the pulmonary system and provide support for GABAB receptors as functionally important for the inhibitory effects of GABA.
KeywordsPlacebo Dioxide Nicotine Histamine Prostaglandin
Unable to display preview. Download preview PDF.
- 6.Chapman RW, Danko G (1989) Inhibitory effect of GABAB receptors on vagally mediated bronchoconstriction in guinea-pigs. FASEB J 3: A440Google Scholar
- 8.Chapman RW, Danko G, Rizzo C, Egan RW, Mauser PJ, Kreutner W (1990) Prejunctional GABAB inhibition of cholinergic, neurally mediated airway contractions in guinea-pigs (to be published)Google Scholar
- 9.Chapman RW, Kreutner W, del Prado M, Hey JA (1990) Role of GABAB receptors on cholinergic and peptidergic bronchoconstriction in guinea-pigs. International Symposium on Peripheral GABAergic Mechanisms, 19-21 July 1990Google Scholar
- 17.Mak JC, Barnes PJ (1989) Peripheral type benzodiazepine receptors in human and guinea-pig lung: characterization and autoradiographic mapping. J Pharmacol Exp Ther 252: 880–885Google Scholar
- 19.Mauser PJ (1989) Inhibitory effect of GABA on the bronchoconstriction due to intracerebroventricular histamine in guinea-pigs. Am Rev Respir Dis 139: A107Google Scholar
- 21.Ray NJ, Jones AJ, Keen P (1989) Evidence that GABAB receptors can modulate release of substance P from capsaicin-sensitive neurons in rat trachea. Br J Pharmacol 97: 562PGoogle Scholar
- 22.Rizzo C, Kreutner W (1989) Prejunctional GABAB inhibition of electrically stimulated contraction in isolated guinea-pig trachea. FASEB J 3: A440Google Scholar