Interleukin-2 by Inhalation: Local Therapy for Metastatic Renal Cell Carcinoma
Continuous high-dose local administration of natural interleukin-2 (nIL-2) is tolerated without side effects in advanced-cancer patients and induces complete remission and local and systemic immunoactivation, as we have shown previously . Those facts support our belief that interleukins should be administered locally, rather than systemically, for effective treatment of carcinoma. Local administration can be expected to induce fewer side effects and to activate tumor-infiltrating immune cells, which are reported to be 100 times more cytotoxic than activated blood cells . The local use of interleukins is also more economical in that it reduces renal loss of small molecules. Although metastatic tumor disease seems not to be suitable for a local approach, the addition of local immunoactivation to systemic treatment might improve the therapeutic effectiveness without increasing toxicity.
KeywordsFatigue Toxicity Catheter Magnesium Albumin
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