New Experimental Approaches to the Adoptive Immunotherapy of Cancer: Cytokines, Gene Therapy, Oncogenes and Transgenic Mice
Adoptive immunotherapy can be defined as transfer to the tumor bearing host of active immunologic cells with antitumor reactivity that can mediate, directly or indirectly, the regression of established tumors. Within this definition there are at least two distinct approaches to this form of therapy: One is a tumor-specific approach, envisioned as mediated by a classical cytotoxic or T-helper lymphocyte, and the second is a nonspecific approach, potentially mediated by natural killer (NK) cells or a promiscuous cytotoxic T cell.
KeywordsMajor Histocompatibility Complex Class Adoptive Immunotherapy Neor Gene Tumor Bearing Host Nonimmunogenic Tumor
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