Abstract
Besides facilitating cell to cell adhesion [8, 17, 20, 22], the molecular interactions between CD2 and its ligand CD58 (LFA-3), as well as between CD11a/18 (LFA-1) and CD54 (ICAM-1) have recently been recognized to participate in lymphocyte activation, recirculation, and effector function including cytolytic activity towards tumor cells [4, 5, 13–15, 18, 21, 24, 25] (Fig. 1). The involvement of CD54 and CD58 in cytolytic effector functions is obvious from blocking experiments employing monoclonal antibodies [12, 19, 23]. Besides the T cell receptor, CD2 is known to be capable of activating resting T lymphocytes and natural killer (NK) cells to express their functional repertoires, including cytotoxic activity [21]. In the case of NK cells, CD2 may represent the central triggering receptor whereas in T effector cells CD2 mediated signals appear to strongly synergize with the T cell receptor in amplifying immune responses [2, 14, 18, 21].
This study is supported by a grant from the Tumorzentrum Heidelberg-Mannheim, C.A. Schirren is a recipient of a fellowship award from the Deutsche Forschungsgemeinschaft (DFG: Schi 284/1-1).
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Schirren, C.A., Völpel, H., Meuer, S.C. (1992). Adhesion Molecules and Their Possible Influence on Immune Surveillance. In: Staehler, G., Pomer, S. (eds) Basic and Clinical Research on Renal Cell Carcinoma. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76863-7_10
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