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The Effect of Clozapine and Other Atypical Antipsychotic Drugs on Negative Symptoms

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Negative Versus Positive Schizophrenia

Abstract

The historical and theoretical basis for the division of the symptoms of schizophrenia into positive and negative has been reviewed by Berrios (1985) and Trimble (1986). There is general agreement that delusions and hallucinations are the cardinal positive symptoms of schizophrenia, but there is more controversy about the domain of negative symptoms. There is general agreement that flat affect, loss of volition, and loss of interest are negative symptoms. Motor retardation and poverty of thought content have also been included (Meltzer and Zureick 1989). There is less concurrence whether bizarre behavior and some types of thought disorder, e.g., marked incoherence, tangentiality, or illogicality, also should be considered positive symptoms (Andreasen and Olson 1982). In the absence of any definitive means of determining which symptoms are positive or negative, it seems appropriate at this time to take a conservative and operational viewpoint as to what constitutes each type.

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Author information

Authors and Affiliations

  1. Department of Psychiatry, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA

    H. Y. Meltzer

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  1. H. Y. Meltzer
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Editor information

Editors and Affiliations

  1. Psychiatrische Universitätsklinik, Sigmund-Freud-Straße 25, W-5300, Bonn, Germany

    Andreas Marneros

  2. Department of Psychiatry, University of Iowa, 500 Newton Road, Iowa City, IO, 52242, USA

    Nancy C. Andreasen MD., Ph. D.

  3. Harvard Departments of Psychiatry and Epidemiology, Brockton/West Roxbury VA Medical Center, 940 Belmont Street, Brockton, MA, 02401, USA

    Ming T. Tsuang MD., Ph. D., D. Sc.

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© 1991 Springer-Verlag Berlin Heidelberg

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Meltzer, H.Y. (1991). The Effect of Clozapine and Other Atypical Antipsychotic Drugs on Negative Symptoms. In: Marneros, A., Andreasen, N.C., Tsuang, M.T. (eds) Negative Versus Positive Schizophrenia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76841-5_22

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  • DOI: https://doi.org/10.1007/978-3-642-76841-5_22

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76843-9

  • Online ISBN: 978-3-642-76841-5

  • eBook Packages: Springer Book Archive

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