Multiple Myeloma: Immunodeficient, Osteolytic, Renal, and Amyloid Syndromes

  • V. A. Almazov
  • E. I. Podoltzeva
  • E. V. Morozova
  • X. O. Sitskaya
  • V. M. Kravzova
  • B. V. Afanasiev
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 35)


Multiple myeloma (MM) is a malignant clonal B-lymphoproliferative disease with typical immunodefficient, osteolytic, renal, amyloid syndromes. Disturbance in the immunologic system appears early and influences the outcome of MM [1]. Light chain isotype suppression (LCIS) [2] and imbalance in T-cells [3] are the factors determining the immunodef-ficiency syndrome. There are no convincing data about changes in natural killer (NK) activity in MM [4, 5]. Osteolysis is the second most frequently observed syndrome, and interleukin-1β (IL-1β), plays the main role in its development [6, 7]. IL-1β probably is also responsible for chronic renal insufficiency (CRI) [7, 8], which is of great prognostic value im MM [9]. Amyloidosis rarely appears in MM patients (6%–15%) [10]. The aims of this study were to clarify the role of LCIS, to determine NK activity of peripheral blood mononuclear cells (PBMC) and bone marrow mononuclear cells (BMMC) and IL-1 production by peripheral blood monocytes (PBM) in MM, and to assess any possible correlation between these data and the course of MM.


Natural Killer Multiple Myeloma Peripheral Blood Mononuclear Cell Bone Lesion Normal Donor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • V. A. Almazov
  • E. I. Podoltzeva
  • E. V. Morozova
  • X. O. Sitskaya
  • V. M. Kravzova
  • B. V. Afanasiev
    • 1
  1. 1.1st Leningrad Medical Institute, USSR Petrov Research Institute of OncologyLeningradUSSR

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