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Monoclonal Blast Cell Proliferation in Transient Myeloproliferative Disorders

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Modern Trends in Human Leukemia IX

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 35))

  • 53 Accesses

Abstract

Transient myeloproliferative disorder is a hematological condition observed during the neonatal period in patients with Down syndrome.[1] This disorder mimics congenital leukemia and the blast cells were often reported to show characteristics compatible with those of mega-karyoblasts [2] or pluripotent stem cells [3]. Although this disorder usually resolves gradually without antileukemic treatment, in some patients, leukemia develops after periods of spontaneous remission [4], raising questions about the benign origin of this disorder.

This work was supported by a Grant-in-Aid from the Ministry of Health and Welfare as part of a comprehensive 10-year Strategy for Cancer Control; by a Grant for Pediatric Research 63–06 from the Ministry of Health and Welfare; by a Grant-in-Aid for Cancer Research; and by the Japanese Foundation for Multidiciplinary Treatment of Cancer.

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References

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Author information

Authors and Affiliations

  1. Department of Virology, The National Children’s Medical Research Center, Tokyo, Japan

    T. Miyashita, S. Mizutani & M. Asada

  2. Department of Pathology, The National Children’s Medical Research Center, Tokyo, Japan

    J. Fujimoto

  3. Department of Hematology/Oncology, Saitama Children’s Hospital, Saitama, Japan

    T. Inaba

  4. Department of Pediatrics, Dokkyo University Medical School, Tochigi, Japan

    T. Furukawa

Authors
  1. T. Miyashita
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  2. S. Mizutani
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  3. M. Asada
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  4. J. Fujimoto
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  5. T. Inaba
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  6. T. Furukawa
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Editor information

Editors and Affiliations

  1. Zentrum für Knochenmark-Transplantation, Universitäts-Krankenhaus Eppendorf, Martinistr. 52, 2000, Hamburg 20, Germany

    Rolf Neth

  2. Shemyakin Institute of Bioorganic Chemistry, Miklukho-Maklaya Str. 16/10, 117871, Moscow, Russia

    Elena Frolova

  3. Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD, 20205, USA

    Robert C. Gallo

  4. Chester Beatty Laboratories, Leukemia Research Fund Centre, Institute of Cancer Research, Fulham Road, London, SW 3 6JB, UK

    Melvyn F. Greaves

  5. Department of Bone Marrow Transplantation, N. N. Petrov Institute of Oncology, St. Petersburg, Russia

    Boris V. Afanasiev

  6. Klinik für Innere Medizin, Abteilung Hämatologie, Medizinische Fakultät der Humboldt-Universität Berlin, Schumannstr. 20/21, 1040, Berlin, Germany

    Elena Elstner

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© 1992 Springer-Verlag Berlin Heidelberg

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Miyashita, T., Mizutani, S., Asada, M., Fujimoto, J., Inaba, T., Furukawa, T. (1992). Monoclonal Blast Cell Proliferation in Transient Myeloproliferative Disorders. In: Neth, R., Frolova, E., Gallo, R.C., Greaves, M.F., Afanasiev, B.V., Elstner, E. (eds) Modern Trends in Human Leukemia IX. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 35. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76829-3_7

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  • DOI: https://doi.org/10.1007/978-3-642-76829-3_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-54360-2

  • Online ISBN: 978-3-642-76829-3

  • eBook Packages: Springer Book Archive

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