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Tumor Rejection Antigens and Immune Surveillance

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Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY,volume 35)

Abstract

The existence of specific tumor rejection antigens was first demonstrated with chemically induced mouse sarcomas: each tumor was found to express a different antigen [1]. Similar findings were made with ultraviolet-induced tumors [2]. Later, the generality of the existence of tumor rejection antigens was questioned when spontaneous mouse tumors were found to be completely incapable of eliciting an immune rejection response [3]. However, further experiments demonstrated that even these tumors express weak transplantation antigens that are potential targets for immune rejection by the syngeneic host [4].

Keywords

  • Mast Cell Line
  • Transplantation Antigen
  • Mouse Tumor Cell
  • Tumor Rejection Antigen
  • Normal Peptide

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© 1992 Springer-Verlag Berlin Heidelberg

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Van den Eynde, B., Lethé, B., Van Pel, A., Boon, T. (1992). Tumor Rejection Antigens and Immune Surveillance. In: Neth, R., Frolova, E., Gallo, R.C., Greaves, M.F., Afanasiev, B.V., Elstner, E. (eds) Modern Trends in Human Leukemia IX. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 35. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76829-3_42

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  • DOI: https://doi.org/10.1007/978-3-642-76829-3_42

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-54360-2

  • Online ISBN: 978-3-642-76829-3

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