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Human Neuroblastoma: Paradigm for a Tumor with Oncogene Amplification and Loss of a Putative Tumor Suppressor Gene

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Modern Trends in Human Leukemia IX

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 35))

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Abstract

Human neuroblastoma cells often carry nonrandom chromosomal abnormalities signaling genetic alterations. Quite frequent are “double minutes” (DMs) and homogeneously staining regions (HSRs), both cytogenetic manifestations of amplified DNA, and chromosome 1 p deletions indicating loss of genetic information. With the identification of amplified N-myc and the demonstration of a consensus deletion spanning the chromosome 1 p36.1–2 region it now appears likely that both amplification of a cellular oncogene and loss of a tumor suppressor gene play important roles in neuroblastoma (Fig.1).

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Authors and Affiliations

  1. Institute for Experimental Pathology, German Cancer Research Center, D-6900, Heidelberg, Germany

    M. Schwab

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  1. M. Schwab
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Editors and Affiliations

  1. Zentrum für Knochenmark-Transplantation, Universitäts-Krankenhaus Eppendorf, Martinistr. 52, 2000, Hamburg 20, Germany

    Rolf Neth

  2. Shemyakin Institute of Bioorganic Chemistry, Miklukho-Maklaya Str. 16/10, 117871, Moscow, Russia

    Elena Frolova

  3. Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD, 20205, USA

    Robert C. Gallo

  4. Chester Beatty Laboratories, Leukemia Research Fund Centre, Institute of Cancer Research, Fulham Road, London, SW 3 6JB, UK

    Melvyn F. Greaves

  5. Department of Bone Marrow Transplantation, N. N. Petrov Institute of Oncology, St. Petersburg, Russia

    Boris V. Afanasiev

  6. Klinik für Innere Medizin, Abteilung Hämatologie, Medizinische Fakultät der Humboldt-Universität Berlin, Schumannstr. 20/21, 1040, Berlin, Germany

    Elena Elstner

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© 1992 Springer-Verlag Berlin Heidelberg

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Schwab, M. (1992). Human Neuroblastoma: Paradigm for a Tumor with Oncogene Amplification and Loss of a Putative Tumor Suppressor Gene. In: Neth, R., Frolova, E., Gallo, R.C., Greaves, M.F., Afanasiev, B.V., Elstner, E. (eds) Modern Trends in Human Leukemia IX. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 35. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76829-3_36

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  • DOI: https://doi.org/10.1007/978-3-642-76829-3_36

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-54360-2

  • Online ISBN: 978-3-642-76829-3

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