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erb-B*a: An “Ignition Spark” for the Xiphophorus Melanoma Machinery?

  • C. Zechel
  • H. Peters
  • U. Schleenbecker
  • A. Anders
  • F. Anders
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 35)

Abstract

Neoplasia is not limited to human beings, or to mammals, but can develop in all taxonomic groups of the recent Eumeta-zoa and even in multicellular plants. It therefore appears to be inherent to the multicellular organization of life [1]. The oncogenes that are associated with human cancer are also distributed throughout the animal kingdom [2–9]. Moreover, tumor-suppressor genes [10] that may control the expression of oncogenes and the manifestation of a tumor phenotype have been identified in humans and were also detected in the invertebrate Drosophila melanogaster and lower vertebrates of the genus Xiphophorus [11–17]. According to one current concept, carcinogenesis is a multistep process that includes activation of one or more “dominant acting oncogenes” and the inactivation of tumor-suppressor genes [18,19]. The lower vertebrate genus Xiphophorus offers the possibility to study both the activation of oncogenes and the inactivation of tumor-suppressor genes.

Keywords

Pigment Cell Epidermal Growth Factor Receptor Gene Spot Pattern Nontumorous Tissue HindIII Fragment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • C. Zechel
  • H. Peters
  • U. Schleenbecker
  • A. Anders
  • F. Anders
    • 1
  1. 1.Genetisches Institut der Justus Liebig-Universität GießenGießenGermany

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