erb-B*a: An “Ignition Spark” for the Xiphophorus Melanoma Machinery?

  • C. Zechel
  • H. Peters
  • U. Schleenbecker
  • A. Anders
  • F. Anders
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 35)


Neoplasia is not limited to human beings, or to mammals, but can develop in all taxonomic groups of the recent Eumeta-zoa and even in multicellular plants. It therefore appears to be inherent to the multicellular organization of life [1]. The oncogenes that are associated with human cancer are also distributed throughout the animal kingdom [2–9]. Moreover, tumor-suppressor genes [10] that may control the expression of oncogenes and the manifestation of a tumor phenotype have been identified in humans and were also detected in the invertebrate Drosophila melanogaster and lower vertebrates of the genus Xiphophorus [11–17]. According to one current concept, carcinogenesis is a multistep process that includes activation of one or more “dominant acting oncogenes” and the inactivation of tumor-suppressor genes [18,19]. The lower vertebrate genus Xiphophorus offers the possibility to study both the activation of oncogenes and the inactivation of tumor-suppressor genes.


Pigment Cell Epidermal Growth Factor Receptor Gene Spot Pattern Nontumorous Tissue HindIII Fragment 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • C. Zechel
  • H. Peters
  • U. Schleenbecker
  • A. Anders
  • F. Anders
    • 1
  1. 1.Genetisches Institut der Justus Liebig-Universität GießenGießenGermany

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