Skip to main content

Molecular Characterization of the Mouse Interleukin-3 Receptor

  • Conference paper
  • 52 Accesses

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 35))

Abstract

erythroblasts, eosinophils, megakaryocytes, mast cells, and pro-B cells [1]. Whereas IL-3 is capable of regulating proliferation and differentiation of various hemopoietic cell lineages, production of IL-3 is limited to antigen-stimulated T cells and activated mast cells and so far there is no evidence indicating that IL-3 is produced in normal bone marrow. Therefore, the major role of IL-3 may be in antigen-induced hemopoiesis rather than normal hemopoiesis in the bone marrow [2].

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Schrader JW (1986) The panspecific hemopoietin of activated T lymphocytes (interleukin-3). Annu Rev Immunol 4:205–230

    Article  PubMed  CAS  Google Scholar 

  2. Miyajima A, Miyatake S, Schreurs J, De VJ, Arai N, Yokota T, Arai K (1988) Responses by T cell-derived lymphokines. FASEB J 2:2462–2473

    PubMed  CAS  Google Scholar 

  3. Schreurs J, Arai K, Miyajima A (1990) Evidence for a low-affinity interleukin-3 receptor. Growth Factors 2:221–234

    Article  PubMed  CAS  Google Scholar 

  4. Koyasu S, Tojo A, Miyajima A, Akiyama T, Kasuga M, Urabe A, Schreurs J, Arai K, Takaku F, Yahara I (1987) Interleukin 3-specific tyrosine phosphorylation of a membrane glycoprotein of Mr 150 000 in multi-factor-dependent myeloid cell lines. EMBO J 6:3979–3984

    PubMed  CAS  Google Scholar 

  5. Moria AO, Schreurs J, Miyajima A, Wang JYJ (1988) Hematopoietic growth factors activate the tyrosine phosphorylation of distinct sets of proteins in interleukin-3-dependent murine cell lines. Mol Cell Biol 8:2214–2218

    Google Scholar 

  6. Isfort R, Stevens D, May WS, Ihel JN (1988) Interleukin 3 binds to a 140-kDa phosphotyrosine-containing cell surface protein. Proc Natl Acad Sci USA 85:7982–7986

    Article  PubMed  CAS  Google Scholar 

  7. Miyajima A, Schreurs J, Wang H-M, Maruyama K, Gorman D, Koyasu S, Yahara I, Wang JYJ, Ohta Y, Arai K (1989) Characterization of the mouse interleukin-3 receptor system. Adv Im-munopharmacol 4:87–93

    Google Scholar 

  8. Cleaveland JL, Dean M, Rosenberg N, Wang JYJ, Rapp UR (1989) Tyrosine kinase oncogenes abrogate interleukin-3 dependence of murine myeloid cells through signaling pathways involving c-myc: conditional regulation of c-myc transcription by temperture-sensitive v-abl. Mol Cell Biol 9:5685–5695

    Google Scholar 

  9. Wang H-M, Collins M, Arai K, Miyajima A (1989) EGF induces differentiation of an IL-3-dependent cell line expressing the EGF receptor. EMBO J 8:3677–3684

    PubMed  CAS  Google Scholar 

  10. Itoh N, Yonehara S, Schreurs J, Gorman DM, Maruyama K, Ishii A, Yahara I, Arai K, Miyajima A (1990) Cloning of an interleukin-3 receptor: a member of a distinct receptor gene family. Science 247:324–327

    Article  PubMed  CAS  Google Scholar 

  11. Gorman DM, Itoh N, Kitamura T, Schreurs J, Yonehara S, Yahara I, Arai K, Miyajima A (1990) Cloning and expression of a gene encoding an interleukin-3 receptor-like protein: identification of another member of the cytokine receptor gene family. Proc Natl Acad Sci USA 87:5459–5463

    Article  PubMed  CAS  Google Scholar 

  12. Hyashida K, Kitamura T, Gorman DM, Arai K, Yokota T, Miyajima A (1990) Molecular cloning of a second subunit of the human GM-CSF receptor: reconstitution of a high affinity GM-CSF receptor. Proc Natl Acad Sci USA 87:9655–9659

    Article  Google Scholar 

  13. Bazan JF (1989) A novel family of growth factor receptors: a common binding domain in the growth hormone, prolactin, erythropoietin, and IL-6 receptors, and the p 75 IL-2 receptor β chain. Biochem Biophys Res Commun 164:788–795

    Article  PubMed  CAS  Google Scholar 

  14. Patthy L (1990) Homology of a domain of the growth hormone/prolactin receptor family with type III modules of fibronec-tin. Cell 61:13–14

    Article  PubMed  CAS  Google Scholar 

  15. Hatakeyama M, Tsudo M, Minamoto S, Kono T, Doi T, Miyata T, Miyasaka M, Taniguchi T (1989) Interleukin-2 receptor β chain gene: generation of three receptor forms by cloned human α and β chain cDNA’s. Science 244:551–556

    Article  PubMed  CAS  Google Scholar 

  16. Taga T, Hibi M, Hirata Y, Yamasaki K, Yasukawa K, Matsuda T, Hirano T, Kishimoto T (1989) Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp 130. Cell 58:573–581

    Article  PubMed  CAS  Google Scholar 

  17. Gearing DP, King JA, Gough NM, Nicola NA (1989) Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor. EMBO J 8:3667–3676

    PubMed  CAS  Google Scholar 

  18. Isfort RJ, Ihle JN (1990) Multiple hematopoietic growth factors signal through tyrosine phosphorylation. Growth Factors 2:213–220

    Article  PubMed  CAS  Google Scholar 

  19. Schreurs J, Hung P, May WS, Arai K, Miyajima A (1991) AIC2A is a component of the purified high affinity mouse IL-3 receptor: temperature-dependent modulation of AIC2A Structure. Int Immunol 3:1231–1242

    Article  PubMed  CAS  Google Scholar 

  20. Gorman DM, Itoh N, Jenkins NA, Gilbert DJ, Copeland NG, Miyajima A (1992) Chromosomal localization and organization of the murine genes encoding the β subunits (AIC2A and AIC2B) of the IL-3, GM-CSF and IL-5 receptors. J Biol Chem (in press)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Miyajima, A. (1992). Molecular Characterization of the Mouse Interleukin-3 Receptor. In: Neth, R., Frolova, E., Gallo, R.C., Greaves, M.F., Afanasiev, B.V., Elstner, E. (eds) Modern Trends in Human Leukemia IX. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 35. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76829-3_29

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-76829-3_29

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-54360-2

  • Online ISBN: 978-3-642-76829-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics