How to localize β-galactoside-specific endogenous lectins and their ligands in tissue sections: A comparison of the application of different histochemical tools in breast cancer

  • A. Schauer
  • S. Gabius
  • U. Brinck
  • H.-J. Gabius


Endogenous lectins and respective tissue glycoconjugates constitute a molecular recognitive system also present in tumor cells (Gabius, 1988a). Disturbances of this system in malignancy can play a key role to modify the social behaviour not only of tumor cells which encompasses various steps within tumor growth and spread (Barondes, 1981; Uhlenbruck et al., 1986; Gabius, 1988a, b, 1991; Lotan and Raz, 1988; Monsigny et al., 1988; Sharon and Lis, 1989). This assumption has provided the rational to at first disclose presence of endogenous lectins in breast tumors and then to demonstrate that neoglycoproteins will allow to localize their specific receptors in this tumor class (Gabius et al., 1986, 1988a; Schauer et al., 1988).


Invasive Ductal Carcinoma Malignant Breast Lesion Immobilize Ligand Endogenous Lectin Sugar Receptor 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • A. Schauer
    • 1
  • S. Gabius
    • 1
    • 2
  • U. Brinck
    • 1
  • H.-J. Gabius
    • 1
    • 3
  1. 1.Department of PathologyUniversity of Göttingen Medical SchoolGöttingenGermany
  2. 2.Department of Hematology/OncologyUniversity of Göttingen, Medical SchoolGöttingenGermany
  3. 3.Department of ChemistryMax-Planck-Institute for Experimental MedicineGöttingenGermany

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